2.4.2.53: undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase
This is an abbreviated version!
For detailed information about undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase, go to the full flat file.
Reaction
Synonyms
ArnC, EC 2.7.8.30, EptA, lipopolysaccharide export system protein LptA, LptA, NMB1638, PA14_39020, PmrF, polymyxin resistance protein F
ECTree
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3982 | AA Sequence |
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General Information
General Information on EC 2.4.2.53 - undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase
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physiological function
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enzyme participates in the biosynthesis of UDP-4-amino-4-deoxy-L-arabinose from UDP-GlcA in polymyxin-resistant Escherichia coli
physiological function
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enzyme takes part in the biosynthesis of UDP-4-amino-4-deoxy-L-arabinose in polymyxin-resistant Escherichia coli. The N-formylation of UDP-4-amino-4-deoxy-L-arabinose is an obligatory step in the biosynthesis of 4-amino-4-deoxy-L-arabinose-modified lipid A in polymyxin-resistant mutants. Only the formylated sugar nucleotide is converted in vitro to an undecaprenyl phosphate-linked form by the enzyme ArnC. Because the L-Ara4N unit attached to lipid A is not derivatized with a formyl group, a deformylase must be acting later in the pathway
physiological function
pmrF inactivation in Yersinia pseudotuberculosis has no effect on bacterial virulence in the mouse