2.4.1.B7: ursodeoxycholate N-acetylglucosaminyltransferase

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For detailed information about ursodeoxycholate N-acetylglucosaminyltransferase, go to the full flat file.

Word Map on EC 2.4.1.B7

2.4.1.B7

glucuronidation

udp-glycosyltransferase

xenobiotics

ugt1a10

xylose

lipophilic

n-acetylglucosamine

udp-glucuronic

glucuronic

primate

n-acetylglucosaminidate

udp-glucuronosyltransferase

medicine

Reaction

7beta-(N-acetyl-D-glucosaminyl)-ursodeoxycholate

Synonyms

UDP glycosyltransferase 3A1, UGT3A1

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.1.B7 ursodeoxycholate N-acetylglucosaminyltransferase

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Results	in table
1	Application
1	Cloned(Commentary)
1	Crystallization (Commentary)
2	General Information
4	KM Value [mM]
1	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
3	Organism
1	pH Optimum
2	Protein Variants
1	Reaction
3	Reference
3	Source Tissue
6	Substrates and Products (Substrate)
1	Subunits
4	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Crystallization

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Crystallization on EC 2.4.1.B7 - ursodeoxycholate N-acetylglucosaminyltransferase

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analysis of homology models docked with UDP-sugar donors indicates that residue N391 in UGT3A1 is able to accommodate the N-acetyl group on C2 of UDP-GlcNAc so that the anomeric carbon atom C1 is optimally situated for catalysis involving residue His35. Replacement of Asn with Phe at position 391 disrupts this catalytically productive orientation of UDP-GlcNAc but allows a more optimal alignment of UDP-Glc for sugar donation

Homo sapiens

722767