2.4.1.B7: ursodeoxycholate N-acetylglucosaminyltransferase
This is an abbreviated version!
For detailed information about ursodeoxycholate N-acetylglucosaminyltransferase, go to the full flat file.
Word Map on EC 2.4.1.B7
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2.4.1.B7
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glucuronidation
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udp-glycosyltransferase
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xenobiotics
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ugt1a10
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xylose
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lipophilic
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n-acetylglucosamine
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udp-glucuronic
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glucuronic
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primate
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n-acetylglucosaminidate
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udp-glucuronosyltransferase
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medicine
- 2.4.1.B7
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glucuronidation
- udp-glycosyltransferase
- xenobiotics
- ugt1a10
- xylose
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lipophilic
- n-acetylglucosamine
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udp-glucuronic
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glucuronic
- primate
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n-acetylglucosaminidate
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udp-glucuronosyltransferase
- medicine
Reaction
Synonyms
UDP glycosyltransferase 3A1, UGT3A1
ECTree
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Substrates Products
Substrates Products on EC 2.4.1.B7 - ursodeoxycholate N-acetylglucosaminyltransferase
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REACTION DIAGRAM
UDP-D-glucose + ursodeoxycholate
UDP + 7beta-D-glucosyl-ursodeoxycholate
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UDP-N-acetyl-D-glucosamine + ursodeoxycholate
UDP + 7beta-(N-acetyl-D-glucosaminyl)-ursodeoxycholate
additional information
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also transfers N-acetyl-D-glucosamine to 17alpha-estradiol, 17beta-estradiol, 4-nitrophenol and 1-naphthol
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?
UDP + 7beta-(N-acetyl-D-glucosaminyl)-ursodeoxycholate
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?
UDP-N-acetyl-D-glucosamine + ursodeoxycholate
UDP + 7beta-(N-acetyl-D-glucosaminyl)-ursodeoxycholate
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i.e. 3',7'-dihydroxy-5'-cholanoic acid. Important role in the metabolism and elimination of ursodeoxycholic acid
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UDP-N-acetyl-D-glucosamine + ursodeoxycholate
UDP + 7beta-(N-acetyl-D-glucosaminyl)-ursodeoxycholate
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i.e. 3',7'-dihydroxy-5'-cholanoic acid. The enzyme uses ursodeoxycholic acid and UDP N-acetylglucosamine in preference to other primary and secondary bile acids, and other UDP sugars such as UDP glucose, UDP glucuronic acid, UDP galactose, and UDP xylose
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?
UDP-N-acetyl-D-glucosamine + ursodeoxycholate
UDP + 7beta-(N-acetyl-D-glucosaminyl)-ursodeoxycholate
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?