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2.4.1.B3: alpha-1,4-glucan synthase

This is an abbreviated version!
For detailed information about alpha-1,4-glucan synthase, go to the full flat file.

Word Map on EC 2.4.1.B3

Reaction

UDP-glucose
+
[alpha-D-glucosyl-(1-3)]n
=
UDP
 +
alpha-1,4-glucosyl-[alpha-D-glucosyl-(1-3)]n

Synonyms

Ags1, Ags1p, cell wall alpha-1,4-glucan synthase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.B3 alpha-1,4-glucan synthase

Engineering

Engineering on EC 2.4.1.B3 - alpha-1,4-glucan synthase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
DELTA1118-1689
enzyme is not able to synthesize alpha-1,4-glucan
DELTA113-724
enzyme is able to synthesize alpha-1,4-glucan
E1526A
markedly reduced ability to complement the cell lysis phenotype and temperature sensitivity of the Schizosaccharomyces pombe ags1-1 mutant, no accumulation of alpha-1,4-glucan
E1534A
able to complement the cell lysis phenotype and temperature sensitivity of the Schizosaccharomyces pombe ags1-1 mutant
G1165A
able to complement the cell lysis phenotype and temperature sensitivity of the Schizosaccharomyces pombe ags1-1 mutant
G696S
temperature-sensitive mutation, gene is functional at 28°C but not at 36°C
K1163Q
able to complement the cell lysis phenotype and temperature sensitivity of the Schizosaccharomyces pombe ags1-1 mutant
K1422Q
reduced accumulation of alpha-1,4-glucan