2.4.1.322: devancosaminyl-vancomycin vancosaminetransferase
This is an abbreviated version!
For detailed information about devancosaminyl-vancomycin vancosaminetransferase, go to the full flat file.
Reaction
Synonyms
desvancosamine-vancomycin TDP-vancosaminyltransferase, GtfD, L-vancosaminyltransferase
ECTree
2.4.1.322 devancosaminyl-vancomycin vancosaminetransferaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.4.1.322 - devancosaminyl-vancomycin vancosaminetransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
dTDP-beta-L-acosamine + devancosaminyl-vancomycin
dTDP + ?
-
-
-
?
dTDP-beta-L-daunosamine + devancosaminyl-vancomycin
dTDP + ?
-
-
-
?
UDP-4-epi-L-vancosamine + devancosaminyl-vancomycin
UDP + epi-L-vancomycin
-
epivancomycin is a hybrid teicoplanin/vancomycin glycopeptide
-
?
UDP-4-epi-vancosamine + 4-deoxy-glucosyl-teicoplanin aglycone
UDP + 4-epi-vancosaminyl-(1,2)-4-deoxy-coplanin heptapeptide
-
-
-
?
UDP-4-epi-vancosamine + devancosaminyl-vancomycin
UDP + epivancomycin
-
epivancomycin is a hybrid teicoplanin/vancomycin glycopeptide
-
?
UDP-L-epi-vancosamine + devancosaminyl-vancomycin
UDP + ?
-
-
-
?
dTDP-beta-L-vancosamine + desvancosaminyl-vancomycin
dTDP + vancomycin
-
-
-
?
dTDP-beta-L-vancosamine + desvancosaminyl-vancomycin
dTDP + vancomycin
-
-
-
?
dTDP-beta-L-vancosamine + devancosaminyl-vancomycin
dTDP + vancomycin
natural substrate
-
-
?
dTDP-beta-L-vancosamine + devancosaminyl-vancomycin
dTDP + vancomycin
the enzyme catalyses the ultimate step in the biosynthesis of the antibiotic vancomycin
-
-
?
dTDP-beta-L-vancosamine + devancosaminyl-vancomycin
dTDP + vancomycin
dTDP-beta-L-vancosamine i.e. dTDP-3-amino-2,3,6-trideoxy-3-C-methyl-beta-L-lyxo-hexopyranose. The enzyme binds TDP in the interdomain cleft, while the aglycone acceptor binds in a deep crevice in the N-terminal domain. The two domains are interdependent in terms of substrate binding and overall structure. Asp13 is a catalytic general base, with a possible secondary role for Thr10
-
-
?
UDP-beta-L-vancosamine + desvancosaminyl-vancomycin
dUDP + vancomycin
-
-
-
?
UDP-beta-L-vancosamine + desvancosaminyl-vancomycin
dUDP + vancomycin
-
-
-
?
additional information
?
-
by tandem reaction of both glucosyltransferase GtfE and L-vancosaminyltransferase GtfD, amino- or deoxy hybrid disaccharide chains can be built on both teicoplanin and vancomycin aglycone scaffolds
-
-
?
additional information
?
-
enzyme shows moderately relaxed donor substrate specificities for the glycosylation of its natural aglycone. It transfers 4-epi-L-vancosamine, L-daunosamine, and L-acosamine with good turnover. 2-Deoxy-L-glucose, 2-deoxy-L-rhamnose, and L-ristosamine are transferred in trace amounts, whereas for substrates containing an amino group at C-4, no product is observed
-
-
?
additional information
?
-
modification of the C- or N-terminus of the vancomycin aglycon does not inhibit completion of the transfer reaction
-
-
?
additional information
?
-
modification of the C- or N-terminus of the vancomycin aglycon does not inhibit completion of the transfer reaction
-
-
?
