2.4.1.310: vancomycin aglycone glucosyltransferase

This is an abbreviated version!
For detailed information about vancomycin aglycone glucosyltransferase, go to the full flat file.

Reaction

Synonyms

GtfB, GtfE

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.310 vancomycin aglycone glucosyltransferase

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Results	in table
61	AA Sequence
2	Application
2	Cloned(Commentary)
1	Crystallization (Commentary)
2	General Information
4	Inhibitors
6	kcat/KM [mM/s]
6	KM Value [mM]
1	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
9	Organism
1	Pathway
1	pH Optimum
6	Protein Variants
2	Purification (Commentary)
1	Reaction
6	Reference
14	Substrates and Products (Substrate)
2	Subunits
5	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
6	Turnover Number [1/s]

Substrates Products

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of the Enzyme Summary Page.

Substrates Products on EC 2.4.1.310 - vancomycin aglycone glucosyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

UDP-alpha-D-glucose + teicoplanin aglycone

UDP + ?

2 entries

UDP-alpha-D-glucose + vancomycin aglycone

UDP + devancoaminyl vancomycin

10 entries

additional information

?

-

2 entries

UDP-alpha-D-glucose + teicoplanin aglycone

UDP + ?

Amycolatopsis orientalis

P96559

very low glucosylation activity

721585

-

-

?

UDP-alpha-D-glucose + teicoplanin aglycone

UDP + ?

Amycolatopsis orientalis A82846

P96559

very low glucosylation activity

721585

-

-

?

UDP-alpha-D-glucose + vancomycin aglycone

UDP + devancoaminyl vancomycin

Amycolatopsis orientalis

-

-

736938

-

-

?

UDP-alpha-D-glucose + vancomycin aglycone

UDP + devancoaminyl vancomycin

Amycolatopsis orientalis

P96559

-

721585

-

-

?

UDP-alpha-D-glucose + vancomycin aglycone

UDP + devancoaminyl vancomycin

Amycolatopsis orientalis

P96559

the enzyme is involved in the biosynthesis of chloroeremomycin

721585

-

-

?

UDP-alpha-D-glucose + vancomycin aglycone

UDP + devancoaminyl vancomycin

Amycolatopsis orientalis

P96559

the enzyme is involved in the biosynthesis of the glycopeptide antibiotic chloroeremomycin

489094

-

-

?

UDP-alpha-D-glucose + vancomycin aglycone

UDP + devancoaminyl vancomycin

Amycolatopsis orientalis

P96559

the enzyme transfers the glucose residue from UDP-glucose to the 4-OH-PheGly4 residue of the vancomycin aglycone

489094

-

-

?

UDP-alpha-D-glucose + vancomycin aglycone

UDP + devancoaminyl vancomycin

Amycolatopsis orientalis A82846

P96559

the enzyme is involved in the biosynthesis of the glycopeptide antibiotic chloroeremomycin

489094

-

-

?

UDP-alpha-D-glucose + vancomycin aglycone

UDP + devancoaminyl vancomycin

Amycolatopsis orientalis A82846

P96559

the enzyme transfers the glucose residue from UDP-glucose to the 4-OH-PheGly4 residue of the vancomycin aglycone

489094

-

-

?

UDP-alpha-D-glucose + vancomycin aglycone

UDP + devancoaminyl vancomycin

Amycolatopsis orientalis A82846

P96559

-

721585

-

-

?

UDP-alpha-D-glucose + vancomycin aglycone

UDP + devancoaminyl vancomycin

Amycolatopsis orientalis A82846

P96559

the enzyme is involved in the biosynthesis of chloroeremomycin

721585

-

-

?

UDP-alpha-D-glucose + vancomycin aglycone

UDP + devancoaminyl vancomycin

Amycolatopsis orientalis ATCC 19795

-

-

736938

-

-

?

additional information

?

-

Amycolatopsis orientalis

-

study on reaction after modification of the vancomycin aglycon. Modification at the N-terminus amine of vancomycin aglycon is well tolerated, whereas C-terminus modification with removal of the acidic carboxylic acid results in a slower, less effective initial glycosylation

736938

-

-

?

additional information

?

-

Amycolatopsis orientalis ATCC 19795

-

study on reaction after modification of the vancomycin aglycon. Modification at the N-terminus amine of vancomycin aglycon is well tolerated, whereas C-terminus modification with removal of the acidic carboxylic acid results in a slower, less effective initial glycosylation

736938

-

-

?