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2.4.1.250: D-inositol-3-phosphate glycosyltransferase

This is an abbreviated version!
For detailed information about D-inositol-3-phosphate glycosyltransferase, go to the full flat file.

Reaction

UDP-N-acetyl-alpha-D-glucosamine
+
1D-myo-inositol 3-phosphate
=
1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate
+
UDP

Synonyms

CgMshA, MshA, MSMEG0924, mycothiol glycosyltransferases

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.250 D-inositol-3-phosphate glycosyltransferase

Systematic Name

Systematic Name on EC 2.4.1.250 - D-inositol-3-phosphate glycosyltransferase

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SYSTEMATIC NAME
IUBMB Comments
UDP-N-acetyl-D-glucosamine:1D-myo-inositol 3-phosphate alpha-D-glycosyltransferase
The enzyme, which belongs to the GT-B fold superfamily, catalyses the first dedicated reaction in the biosynthesis of mycothiol [1]. The substrate was initially believed to be inositol, but eventually shown to be D-myo-inositol 3-phosphate [2]. A substantial conformational change occurs upon UDP binding, which generates the binding site for D-myo-inositol 3-phosphate [3].