2.4.1.250: D-inositol-3-phosphate glycosyltransferase
This is an abbreviated version!
For detailed information about D-inositol-3-phosphate glycosyltransferase, go to the full flat file.
Reaction
Synonyms
CgMshA, MshA, MSMEG0924, mycothiol glycosyltransferases
ECTree
Advanced search results
Substrates Products
Substrates Products on EC 2.4.1.250 - D-inositol-3-phosphate glycosyltransferase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REACTION DIAGRAM
1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + UDP
UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate
1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + UDP
the reaction proceeds via a front-side SNi-like concerted reaction mechanism
-
-
?
1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + UDP
the reaction proceeds via a front-side SNi-like concerted reaction mechanism
-
-
?
?
at 10% of the activity with 1D-myo-inositol 3-phosphate
-
-
?
UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 1-phosphate
?
Mycolicibacterium smegmatis mc(2)155 / ATCC 700084
at 10% of the activity with 1D-myo-inositol 3-phosphate
-
-
?
1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP
-
1D-myo-inositol 3-phosphate i.e. 1L-myo-inositol 1-phosphate, committed step of mycothiol biosynthesis
-
-
?
UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate
1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP
-
1D-myo-inositol 3-phosphate i.e. 1L-myo-inositol 1-phosphate. Molecular models of the ternary complex suggest a mechanism in which the beta-phosphate of the substrate, UDP-N-acetylglucosamine, promotes the nucleophilic attack of the 3-hydroxyl group of 1D-myo-inositol 3-phosphate while at the same time promoting the cleavage of the sugar nucleotide bond
-
-
?
UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate
1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP
-
1D-myo-inositol 3-phosphate i.e. 1L-myo-inositol 1-phosphate, the mshA gene is essential for the growth of Mycobacterium tuberculosis
-
-
?
UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate
1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP
-
1D-myo-inositol 3-phosphate i.e. 1L-myo-inositol 1-phosphate
-
-
?
UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate
1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP
-
1D-myo-inositol 3-phosphate i.e. 1L-myo-inositol 1-phosphate, the mshA gene is essential for the growth of Mycobacterium tuberculosis
-
-
?
UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate
1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP
-
1D-myo-inositol 3-phosphate i.e. 1L-myo-inositol 1-phosphate
-
-
?
UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate
1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP
-
1D-myo-inositol 3-phosphate i.e. 1L-myo-inositol 1-phosphate, mycothiol biosynthesis
-
-
?
UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate
1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP
1D-myo-inositol 3-phosphate i.e. 1L-myo-inositol 1-phosphate, mycothiol biosynthesis
-
-
?
UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate
1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP
1D-myo-inositol 3-phosphate i.e. 1L-myo-inositol 1-phosphate. Little activity is obtained with myo-inositol, 1D-myo-inositol 1-phosphate, or myo-inositol 2-phosphate as the N-acetylglucosamine acceptor. 1D-myo-inositol 1-phosphate is neither a good substrate nor an inhibitor of MshA. Therfore the commercially available 1DL-myo-inositol 1-phosphate can be used as substrate for MshA assays without complications
-
-
?
UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate
1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP
Mycolicibacterium smegmatis mc(2)155 / ATCC 700084
1D-myo-inositol 3-phosphate i.e. 1L-myo-inositol 1-phosphate, mycothiol biosynthesis
-
-
?
UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate
1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP
Mycolicibacterium smegmatis mc(2)155 / ATCC 700084
1D-myo-inositol 3-phosphate i.e. 1L-myo-inositol 1-phosphate. Little activity is obtained with myo-inositol, 1D-myo-inositol 1-phosphate, or myo-inositol 2-phosphate as the N-acetylglucosamine acceptor. 1D-myo-inositol 1-phosphate is neither a good substrate nor an inhibitor of MshA. Therfore the commercially available 1DL-myo-inositol 1-phosphate can be used as substrate for MshA assays without complications
-
-
?
?
at 10% of the activity with 1D-myo-inositol 3-phosphate
-
-
?
UDP-N-acetyl-D-glucosamine + myo-inositol 2-phosphate
?
Mycolicibacterium smegmatis mc(2)155 / ATCC 700084
at 10% of the activity with 1D-myo-inositol 3-phosphate
-
-
?