2.4.1.152: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase
This is an abbreviated version!
For detailed information about 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase, go to the full flat file.
Word Map on EC 2.4.1.152
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2.4.1.152
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sialylated
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fucosylated
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selectins
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fuc-tiii
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n-acetyllactosamine
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medicine
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synthesis
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alpha1,3-fucosylation
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lewisx
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fuc-ts
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fuct-iv
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alpha-2-l-fucosyltransferase
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analysis
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drug development
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biotechnology
- 2.4.1.152
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sialylated
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fucosylated
- selectins
- fuc-tiii
- n-acetyllactosamine
- medicine
- synthesis
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alpha1,3-fucosylation
- lewisx
- fuc-ts
- fuct-iv
- alpha-2-l-fucosyltransferase
- analysis
- drug development
- biotechnology
Reaction
Synonyms
11639FucT, alpha (1,3) fucosyltransferase, alpha (1,3)-fucosyltransferase, alpha 1,3 fucosyltransferase, alpha 1,3/4 fucosyltransferase Lewis 2, alpha 3-fucosyltransferase IX, alpha(1,3)-fucosyltransferase VII, alpha(1,3)fucosyltransferase IV, alpha(1,3)fucosyltransferase VII, alpha(1-3)fucosyltransferase, alpha-(1,3)-fucosyltransferase, alpha-(1,3)-fucosyltransferase 11, alpha-(1,3)-fucosyltransferase IXa, alpha-(1,3/1,4)-fucosyltransferase, alpha-(1,3/1,4)-FucT, alpha-1,3 FucT-VII, alpha-1,3-fucosyltransferase, alpha-1,3-fucosyltransferase 3, alpha-1,3-fucosyltransferase 9D, alpha-1,3-fucosyltransferase VI, alpha-1,3-FucT3, alpha-13-fucosyltransferase VII, alpha-3-fucosyltransferase, alpha-3-L-fucosyltransferase, alpha1,3 fucosyltransferase, alpha1,3 fucosyltransferase VII, alpha1,3 FucT-VII, alpha1,3-fucosyltransferase, alpha1,3-fucosyltransferase 4, alpha1,3-fucosyltransferase 9, alpha1,3-fucosyltransferase C, alpha1,3-fucosyltransferase IX, alpha1,3-fucosyltransferase V, alpha1,3-fucosyltransferase VI, alpha1,3-fucosyltransferase-F, alpha1,3-FucT, alpha1,3-FucTIX, alpha1,3/4-fucosyltransferase, alpha1,3/4-fucosyltransferase VI, alpha1,3FT, alpha1,3fucosyltransferase-VII, alpha1-3 fucosyltransferase, alpha1-3 fucosyltransferase-VII, alpha1-3 FucT, alpha1->3fucosyltransferase, alpha3-fucosyltransferase, alpha3-fucosyltransferase IX, alpha3-fucosyltransferase VII, alpha3-fucosyltransferase-V, alpha3-fucosyltransferase-VI, alpha3/4FucT, CEFT-3, CEFT-4, FT-IV, FT-VII, Fuc-Tb, Fuc-TV, Fuc-TXI, fucosyltransferase, fucosyltransferase 11, fucosyltransferase 4, fucosyltransferase 7, fucosyltransferase IV, fucosyltransferase IX, fucosyltransferase V, fucosyltransferase VI, fucosyltransferase VII, fucosyltransferase, guanosine diphosphofucose-glucoside alpha1-->3-, fucosyltransferase-7, fucosyltransferase-VII, fucosyltransferaseIX, FucT, FucT 9, FucT IX, FucT V, FucT-IX, FucT-VI, FucT-VII, FucT-XI, FucT7, FucT9, FucTC, FucTD, FucTe, FucTVII, FUT VI, FuT-F, FUT-VI, FUT10, FUT11, FUT3, FUT4, FUT5, FUT6, FUT7, Fut9, FUT9a, FutA, FutB, galactoside 3-fucosyltransferase, galactoside 3-L-fucosyltransferase 11, GDL-L-fucose:N-acetyl-beta-D-glucosaminyl alpha-3-L-fucosyltransferase, GDP-Fuc:Galbeta1-4GlcNAc (Fuc to GlcNAc) alpha1-3 fucosyltransferase, GDP-fucose:beta-D-N-acetylglucosaminide 3-alpha-fucosyltransferase, GDP-fucose:Galbeta(1-4)GlcNAc-R alpha(1-3)fucosyltransferase, GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-galactosaminyl-R 3-L-fucosyltransferase, guanosine diphosphofucose glucoside alpha1->3fucosyltransferase, HP_0379, HP_0651, Lewis type alpha1,3-FucT, lewis-negative alpha-3-fucosyltransferase, LEwis-type alpha1,3-fucosyltransferase, Lj4g3v0598850, More, plasma alpha-3-fucosyltransferase, PylT, rat fucosyltransferase VII, rFuc-TVII, rFUT7, sFUT9, UA948FucT, WP-000487420, WP-000487428, WP-000487430, XM_016585847, zebrafisha1-3fucosyltrasferase 1, zFT1
ECTree
2.4.1.152 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.4.1.152 - 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
GDP-beta-fucose + alpha2,3-sialyl N-acetyllactosaminyl-R
GDP + alpha1,3-fucosyl-alpha2,3-sialyl-N-acetyllactosaminyl-R
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FucT-VII and FucT-IV
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GDP-beta-L-fucose + asialo-erythropoietin
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wild-type FUT9 efficiently fucosylates di-, tri- and tetraantennary N-glycans from asialoEPO
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?
GDP-beta-L-fucose + beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R
GDP + beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-R
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?
GDP-beta-L-fucose + N-acetyllactosamine
GDP + L-Fuc-alpha-(1->3)-[D-Gal-beta(1->4)]-D-GlcNac
GDP-beta-L-fucose + Neu5Acalpha-(2,3)-Galbeta-(1,4)-GlcNAcbeta-R
GDP + Neu5Acalpha-(2,3)-Galbeta-(1,4)-[Fucalpha-(1,3)]-GlcNAcbeta-R
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the last step in sLex epitope formation is catalyzed byalpha(1,3)-fucosyltransferase VII, i.e. FucTVII, which transfers a fucosyl moiety from GDP-fucose to the core oligosaccharide structures, overview
i.e. antigen sLex
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?
GDP-beta-L-fucose + NeuAcalpha(2,3)-Galbeta(1,4)-GlcNAc-R
GDP + NeuAcalpha(2,3)-Galbeta(1,4)[Fucalpha1-3]-GlcNAc-R
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sialyl-Lewisx terminal structure
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?
GDP-beta-L-fucose + NeuAcalpha(2,3)-Galbeta(1,4)[SO3H-6]-GlcNAc-R
GDP + NeuAcalpha(2,3)-Galbeta(1,4)[Fucalpha1-3][SO3H-6]-GlcNAc-R
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sialyl-Lewisx terminal structure
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?
GDP-beta-L-fucose + N-acetyllactosamine
GDP + L-Fuc-alpha-(1->3)-[D-Gal-beta(1->4)]-D-GlcNac
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?
GDP-beta-L-fucose + N-acetyllactosamine
GDP + L-Fuc-alpha-(1->3)-[D-Gal-beta(1->4)]-D-GlcNac
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?
GDP-beta-L-fucose + N-acetyllactosamine
GDP + L-Fuc-alpha-(1->3)-[D-Gal-beta(1->4)]-D-GlcNac
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additional information
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evolution of vertebrate alpha-1,3/4-fucosyltransferases
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additional information
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evolution of vertebrate alpha-1,3/4-fucosyltransferases
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additional information
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evolution of vertebrate alpha-1,3/4-fucosyltransferases
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additional information
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evolution of vertebrate alpha-1,3/4-fucosyltransferases
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additional information
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enzyme is involved in the expression of the sialyl-LewisX determinant, a ligand for E- and P-selectin
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additional information
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the hepatocellular enzyme is involved in the synthesis of sialosyl LeX determinants on cirrhotic alpha1AGP
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additional information
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the gene is capable of directing expression of the Lewis x Galbeta(1,4)(Fucalpha(1,3))GlcNAc, sialyl Lewis x NeuNAcalpha(2,3)Galbeta(1,4)(Fucalpha(1,3))GlcNAc, and difucosyl sialyl Lewis x NeuNAcalpha(2,3)Galbeta(1,4)(Fucalpha(1,3))GlcNAcbeta(1,3)Galbeta(1,4)(Fucalpha(1,3))GlcNAc epitopes
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additional information
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the gene is capable of directing expression of the Lewis x Galbeta(1,4)(Fucalpha(1,3))GlcNAc, sialyl Lewis x NeuNAcalpha(2,3)Galbeta(1,4)(Fucalpha(1,3))GlcNAc, and difucosyl sialyl Lewis x NeuNAcalpha(2,3)Galbeta(1,4)(Fucalpha(1,3))GlcNAcbeta(1,3)Galbeta(1,4)(Fucalpha(1,3))GlcNAc epitopes
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additional information
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the enzyme is involved in the biosynthesis of the E-selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates
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additional information
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the enzyme is involved in the biosynthesis of the E-selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates
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additional information
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the enzyme is involved in the biosynthesis of the E-selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates
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additional information
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the enzyme is involved in the biosynthesis of the E-selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates
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additional information
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FucT-VI is involved in the biosynthesis of nonsialylated Lewis X, i.e. Lex, antigen, FucT VII is essential for biosynthesis of the carbohydrate antigen sialyl Lewis X, i.e. sLex, in leukocytes, FucT VII and FucT IV are essential for biosynthesis of selectin binding ligands in T-cells
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additional information
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evolution of vertebrate alpha-1,3/4-fucosyltransferases
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additional information
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recombinant alpha1,3FucT-VII acts as a potential antiapoptotic factor in H7721 cells after induction of apoptosis by UV irradiation, overview
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additional information
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the alpha3-fucosyltransferase IX, FUT9, catalyses the transfer of fucose in an alpha3 linkage onto terminal type II Galbeta4GlcNAc acceptors, the final step in the biosynthesis of the Lewisx epitope, in neurons, overview
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additional information
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the alpha3-fucosyltransferase IX, FUT9, catalyses the transfer of fucose in an alpha3 linkage onto terminal type II Galbeta4GlcNAc acceptors, the final step in the biosynthesis of the Lewisx epitope, in neurons, overview
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additional information
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the final step in the biosynthesis of Lex is catalyzed by alpha3-fucosyltransferases with different specificites, which add a fucose residue to type II-based oligosaccharide chains, the alpha3-FUT activity in NT2 cells is the result of combined activities of FUT4 ad FUT9 whereas in NT2N cells only FUT9 participatein the Lex biosynthesis, overview
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additional information
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the final step in the biosynthesis of Lex is catalyzed by alpha3-fucosyltransferases with different specificites, which add a fucose residue to type II-based oligosaccharide chains, the alpha3-FUT activity in NT2 cells is the result of combined activities of FUT4 ad FUT9 whereas in NT2N cells only FUT9 participatein the Lex biosynthesis, overview
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additional information
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the natural substrate of FucTVII is a glycoprotein carrying 3'SLN-terminated polylactoseamine chains, FucTVII activity is required for synthesis of the sialyl-Lewis X glycoepitopes on the E- and P-selectin ligands, necessary for lymphocyte migration into the skin
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additional information
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Fuc-TVII participates in the generation of alpha(1,3)fucosylated ligands for L-selectin, evidence for a role for this enzyme in E- and P-selectin ligand expression in leukocytes
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additional information
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evolution of vertebrate alpha-1,3/4-fucosyltransferases
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additional information
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evolution of vertebrate alpha-1,3/4-fucosyltransferases
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?
additional information
?
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evolution of vertebrate alpha-1,3/4-fucosyltransferases
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?
additional information
?
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evolution of vertebrate alpha-1,3/4-fucosyltransferases
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?
additional information
?
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evolution of vertebrate alpha-1,3/4-fucosyltransferases
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?
additional information
?
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evolution of vertebrate alpha-1,3/4-fucosyltransferases
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?
additional information
?
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evolution of vertebrate alpha-1,3/4-fucosyltransferases
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?
additional information
?
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evolution of vertebrate alpha-1,3/4-fucosyltransferases
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?
additional information
?
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evolution of vertebrate alpha-1,3/4-fucosyltransferases
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?
additional information
?
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evolution of vertebrate alpha-1,3/4-fucosyltransferases
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