Literature summary for 2.4.1.152 extracted from

Groux-Degroote, S.; Krzewinski-Recchi, M.A.; Cazet, A.; Vincent, A.; Lehoux, S.; Lafitte, J.J.; Van Seuningen, I.; Delannoy, P.
IL-6 and IL-8 increase the expression of glycosyltransferases and sulfotransferases involved in the biosynthesis of sialylated and/or sulfated Lewisx epitopes in the human bronchial mucosa (2008), Biochem. J., 410, 213-223.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	interleukin-6 or interleukin-8 significantly induce the expression of alpha1,3/4-fucosyltransferases, the amounts of sialyl-Lewisx and 6-sulfo-sialyl-Lewisx epitopes at the periphery of high molecular-mass proteins, including MUC4, are increased	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
gene FUT11, expression analysis in bronchial mucosa of cystic fibrosis patients	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
GDP-beta-L-fucose + NeuAcalpha(2,3)-Galbeta(1,4)-GlcNAc-R	Homo sapiens	sialyl-Lewisx terminal structure	GDP + NeuAcalpha(2,3)-Galbeta(1,4)[Fucalpha1-3]-GlcNAc-R	-	?
GDP-beta-L-fucose + NeuAcalpha(2,3)-Galbeta(1,4)[SO3H-6]-GlcNAc-R	Homo sapiens	sialyl-Lewisx terminal structure	GDP + NeuAcalpha(2,3)-Galbeta(1,4)[Fucalpha1-3][SO3H-6]-GlcNAc-R	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	gene FUT11	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
bronchial mucosa	from patients suffering from cystic fibrosis	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GDP-beta-L-fucose + NeuAcalpha(2,3)-Galbeta(1,4)-GlcNAc-R	sialyl-Lewisx terminal structure	Homo sapiens	GDP + NeuAcalpha(2,3)-Galbeta(1,4)[Fucalpha1-3]-GlcNAc-R	-	?
GDP-beta-L-fucose + NeuAcalpha(2,3)-Galbeta(1,4)[SO3H-6]-GlcNAc-R	sialyl-Lewisx terminal structure	Homo sapiens	GDP + NeuAcalpha(2,3)-Galbeta(1,4)[Fucalpha1-3][SO3H-6]-GlcNAc-R	-	?

Synonyms

Synonyms	Comment	Organism
alpha1,3/4-fucosyltransferase	-	Homo sapiens
fucosyltransferase 11	-	Homo sapiens
FUT11	-	Homo sapiens

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Release 2023.1 (January 2023)