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2.3.2.20: cyclo(L-leucyl-L-phenylalanyl) synthase

This is an abbreviated version!
For detailed information about cyclo(L-leucyl-L-phenylalanyl) synthase, go to the full flat file.

Word Map on EC 2.3.2.20

Reaction

L-leucyl-tRNALeu
+
L-phenylalanyl-tRNAPhe
=
tRNALeu
 +
tRNAPhe
 +
cyclo(L-leucyl-L-phenylalanyl)

Synonyms

AlbC, BcmA, CDP, CDPS, CDPS 22, CDPS39, cFL synthase, cyclodipeptide synthase, cyclodipeptide synthases, Fdum-CDPS, Nbra-CDPS, NcdA, NCTC11370_02388, Ndas_1148, NozA, O3I_025450, Rgry-CDPS, RICGR_0139

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.2 Aminoacyltransferases
                2.3.2.20 cyclo(L-leucyl-L-phenylalanyl) synthase

Engineering

Engineering on EC 2.3.2.20 - cyclo(L-leucyl-L-phenylalanyl) synthase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
E182A
mutation in putative catalytic pocket, inactive
E182D
mutation in putative catalytic pocket, about 1% of wild-type activity
E182Q
mutation in putative catalytic pocket, inactive
F59A
about 10% of wild-type activity
G35A
mutation in putative catalytic pocket, about 5% of wild-type activity
G79A
about 70% of wild-type activity
L200N
mutation in putative catalytic pocket
L33Y/L185D
mutation in putative catalytic pocket, inactive
P184A
about 40% of wild-type activity
S37A
mutation in putative catalytic pocket, inactive
S37C
mutation in putative catalytic pocket, about 5% of wild-type activity
Y178A
mutation in putative catalytic pocket, inactive
Y178F
mutation in putative catalytic pocket, about 10% of wild-type activity
Y202A
mutation in putative catalytic pocket
Y202F