2.3.2.16: lipid II:glycine glycyltransferase

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For detailed information about lipid II:glycine glycyltransferase, go to the full flat file.

Reaction

Synonyms

FemX

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.2 Aminoacyltransferases

                2.3.2.16 lipid II:glycine glycyltransferase

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Results	in table
412	AA Sequence
3	Cloned(Commentary)
6	General Information
4	Molecular Weight [Da]
6	Organism
6	Pathway
1	PDB ID
1	pH Optimum
2	Posttranslational Modification
22	Protein Variants
2	Purification (Commentary)
1	Reaction
6	Reference
5	Substrates and Products (Substrate)
4	Subunits
4	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 2.3.2.16 - lipid II:glycine glycyltransferase

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SYSTEMATIC NAME

IUBMB Comments

alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine N6-glycyltransferase

The enzyme from Staphylococcus aureus catalyses the transfer of glycine from a charged tRNA to MurNAc-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala-diphosphoundecaprenyl-GlcNAc (lipid II), attaching it to the N6 of the L-Lys at position 3 of the pentapeptide. This is the first step in the synthesis of the pentaglycine interpeptide bridge that is used in S. aureus for the crosslinking of different glycan strands to each other. Four additional Gly residues are subsequently attached by EC 2.3.2.17 (N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-glycyl)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase) and EC 2.3.2.18 (N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-triglycine)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase).