2.3.2.16: lipid II:glycine glycyltransferase

This is an abbreviated version!
For detailed information about lipid II:glycine glycyltransferase, go to the full flat file.

Reaction

N-acetylmuramoyl-L-alanyl-D-isoglutaminyl-L-lysyl-D-alanyl-D-alanine-diphospho-ditrans,octacis-undecaprenyl-N-acetyl-D-glucosamine

N-acetylmuramoyl-L-alanyl-D-isoglutaminyl-L-lysyl-(N6-glycyl)-D-alanyl-D-alanine-diphospho-ditrans,octacis-undecaprenyl-N-acetyl-D-glucosamine

Synonyms

FemX

ECTree

2 Transferases

2.3 Acyltransferases

2.3.2 Aminoacyltransferases

2.3.2.16 lipid II:glycine glycyltransferase

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Results	in table
412	AA Sequence
3	Cloned(Commentary)
6	General Information
4	Molecular Weight [Da]
6	Organism
6	Pathway
1	PDB ID
1	pH Optimum
2	Posttranslational Modification
22	Protein Variants
2	Purification (Commentary)
1	Reaction
6	Reference
5	Substrates and Products (Substrate)
4	Subunits
4	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Substrates Products

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Substrates Products on EC 2.3.2.16 - lipid II:glycine glycyltransferase

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glycyl-tRNA(E.coli) + UDP-MurNAc-Ala-D-Glu-Lys-D-Ala-D-Ala

tRNA(E.coli) + UDP-MurNAc-Ala-D-Glu-(N6-Gly)Lys-D-Ala-D-Ala

Weissella viridescens

Q9EY50

addition of serine and alanine is preferred over glycine

704401

glycyl-tRNAGly + N-acetylmuramoyl-L-alanyl-D-isoglutaminyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine

tRNAGly + N-acetylmuramoyl-L-alanyl-D-isoglutaminyl-L-lysyl-(N6-glycyl)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine

Staphylococcus aureus

i.e. lipid II. Enzyme uses lipid II exclusively as acceptor

705764

L-alanyl-tRNA(E.coli) + UDP-MurNAc-Ala-D-Glu-Lys-D-Ala-D-Ala

tRNA(E.coli) + UDP-MurNAc-Ala-D-Glu-(N6-L-Ala)Lys-D-Ala-D-Ala

Weissella viridescens

Q9EY50

addition of serine and alanine is preferred over glycine

704401

L-seryl-tRNA(E.coli) + UDP-MurNAc-Ala-D-Glu-Lys-D-Ala-D-Ala

tRNA(E.coli) + UDP-MurNAc-Ala-D-Glu-(N6-L-Ser)Lys-D-Ala-D-Ala

Weissella viridescens

Q9EY50

addition of serine and alanine is preferred over glycine

704401

additional information

Weissella viridescens

Q9EY50

Assays with mixtures of alanyl-, seryl-, and glycyl-tRNAs result in mixtures of the expected UDP-MurNAc hexapeptides, but no larger species. FemX adds only the first residue of the interchain peptide

704401