2.3.1.252: mycolipanoate synthase
This is an abbreviated version!
For detailed information about mycolipanoate synthase, go to the full flat file.
Reaction
+ 3 (S)-methylmalonyl-CoA + 6 NADPH + 6 H+ + = + 4 CoA + 3 CO2 + 6 NADP+ + 3 H2O
Synonyms
Msl3, Pks2, pks3, polyketide beta-ketoacyl synthase
ECTree
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Reference
Reference on EC 2.3.1.252 - mycolipanoate synthase
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Sirakova, T.D.; Thirumala, A.K.; Dubey, V.S.; Sprecher, H.; Kolattukudy, P.E.
The Mycobacterium tuberculosis pks2 gene encodes the synthase for the hepta- and octamethyl-branched fatty acids required for sulfolipid synthesis
J. Biol. Chem.
276
16833-16839
2001
Mycobacterium tuberculosis (P9WQE9), Mycobacterium tuberculosis ATCC 25618 (P9WQE9)
Goyal, R.; Das, A.K.; Singh, R.; Singh, P.K.; Korpole, S.; Sarkar, D.
Phosphorylation of PhoP protein plays direct regulatory role in lipid biosynthesis of Mycobacterium tuberculosis
J. Biol. Chem.
286
45197-45208
2011
Mycobacterium tuberculosis (A0A089QRB9), Mycobacterium tuberculosis H37Rv (A0A089QRB9)
Dubey, V.S.; Sirakova, T.D.; Kolattukudy, P.E.
Disruption of msl3 abolishes the synthesis of mycolipanoic and mycolipenic acids required for polyacyltrehalose synthesis in Mycobacterium tuberculosis H37Rv and causes cell aggregation
Mol. Microbiol.
45
1451-1459
2002
Mycobacterium tuberculosis (A0A089QRB9), Mycobacterium tuberculosis H37Rv (A0A089QRB9)
Walters, S.B.; Dubnau, E.; Kolesnikova, I.; Laval, F.; Daffe, M.; Smith, I.
The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis
Mol. Microbiol.
60
312-330
2006
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
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