2.3.1.252: mycolipanoate synthase

This is an abbreviated version!
For detailed information about mycolipanoate synthase, go to the full flat file.

Reaction

+ 3 (S)-methylmalonyl-CoA + 6 NADPH + 6 H+ +

+ 4 CoA + 3 CO2 + 6 NADP⁺ + 3 H2O

Synonyms

Msl3, Pks2, pks3, polyketide beta-ketoacyl synthase

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.252 mycolipanoate synthase

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Results	in table
6	AA Sequence
2	Expression
2	General Information
1	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
200	Organism
1	Pathway
1	Reaction
8	Reference
4	Substrates and Products (Substrate)
12	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 2.3.1.252 - mycolipanoate synthase

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long-chain acyl-CoA:(S)-methylmalonyl-CoA C-acyltransferase (mycolipanoate-forming)

This mycobacterial enzyme accepts long-chain fatty acyl groups from their CoA esters and extends them by incorporation of three methylmalonyl (but not malonyl) residues, forming trimethyl-branched fatty-acids such as (2S,4S,6S)-2,4,6-trimethyltetracosanoate (C27-mycolipanoate). Since the enzyme lacks a thioesterase domain, the product remains bound to the enzyme and requires additional enzyme(s) for removal.