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2.3.1.207: beta-ketodecanoyl-[acyl-carrier-protein] synthase

This is an abbreviated version!
For detailed information about beta-ketodecanoyl-[acyl-carrier-protein] synthase, go to the full flat file.

Reaction

octanoyl-CoA
+
a malonyl-[acyl-carrier protein]
=
a 3-oxodecanoyl-[acyl-carrier protein]
+
CoA
+
CO2

Synonyms

beta-ketoacyl synthase, FabY, PA3286 protein

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.207 beta-ketodecanoyl-[acyl-carrier-protein] synthase

Engineering

Engineering on EC 2.3.1.207 - beta-ketodecanoyl-[acyl-carrier-protein] synthase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
gene fabY is replaced with fabH (pTMT123) or deleted (pTMT124) in Pseudomonas aeruginosa strain PAO1. The fabY deletion strain grows slowly in comparison to the fabHEc exchange control without C10 supplementation, synthetic lethal analysis for fabY with KASIII domain fabH orthologues and fatty acid rescue, overview. The fabY deletion is synthetic lethal when introduced into the KASIII domain knockout strain TMT16. Synthetic lethal relationship between PA3286 and fabY indicates shared acetyl-CoA:malonyl-ACP condensing activity. PA3286 cross complements fabH and confers a fatty acid shunt in Escherichia coli