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2.3.1.199: very-long-chain 3-oxoacyl-CoA synthase

This is an abbreviated version!
For detailed information about very-long-chain 3-oxoacyl-CoA synthase, go to the full flat file.

Word Map on EC 2.3.1.199

Reaction

a very-long-chain acyl-CoA
+
malonyl-CoA
=
a very-long-chain 3-oxoacyl-CoA
 +
CO2
 +
CoA

Synonyms

3-ketoacyl CoA synthase, 3-ketoacyl-CoA synthase, acyl-CoA elongase, At1g01120, At2g26640, beta-ketoacyl CoA synthase, beta-ketoacyl-CoA synthase, Cer-zh, CER2-LIKE1, CER2-LIKE2, CER26, CER26L, CER6, CER60, condensing enzyme, Cut1, CUT1L, EC 2.3.1.119, ECERIFERUM 26, ECERIFERUM 26-like, ELO, ELo1, Elo1p, Elo2p, Elo3p, EloA, ELOVL1, ELOVL5, Elovl6, ELOVL7, FA elongase, FAE1, FAE1 beta-ketoacyl-CoA synthase, FAE1 KCS, Fatty acid elongase, fatty acid elongase 1, fatty acid elongation 1, fatty acid elongation1, KCS, Kcs1, KCS17, KCS2, KCS2/DAISY, KCS20, MALCE1, microsomal fatty acid elongase, Onion2, Os03g0220100, Os10 g0416200, seed-specific condensing enzyme, very-long-chain fatty acid condensing enzyme, very-long-chain fatty acid-condensing enzyme, VLCFA condensing enzyme, VLCFA elongase, WSL4

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.199 very-long-chain 3-oxoacyl-CoA synthase

Expression

Expression on EC 2.3.1.199 - very-long-chain 3-oxoacyl-CoA synthase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
CER6 mRNA increases to more than 7fold in 10 days post anthesis
functional expression in yeast Saccharomyces cerevisiae results in the accumulation of 18-, 19-, and 20-carbon monounsaturated fatty acids and eicosanoic acid. The transformant efficiently elongates exogenous 9-hexadecenoic acid, 9,12-octadecadienoic acid, and 9,12,15-octadecatrienoic acid
in fasting conditions the effect of lipid level possibly prevails over or interacted with fatty acid composition in regulating the expression of elovl5, which is down-regulated in the liver of fish fed the high lipid diets
isoform KCS20 mRNA expression is stimulated about 2fold by drought stress (air-drying for 6 h). Isoform KCS2/DAISY mRNA expression is stimulated about 4 fold at 200 mM mannitol, about 60fold at drought stress, about 3fold at 100 mM NaCl, and about 20fold at 0.1 mM abscisic acid
-
light is required for expression and expression is increased by salt and drought treatments
-
the ELO1 gene is rapidly induced in wild type cells that are supplemented with myristic acid
the ELO1 gene is repressed in wild type cells that are supplemented with palmitic acid and stearic acid
the expression of 1-aminocyclopropane-1-carboxylic acid synthase ACS1, CUT1L, and ATP-binding cassette transporter RCN1/OsABCG5 is induced predominantly in the outer part of roots under stagnant conditions