2.3.1.194: acetoacetyl-CoA synthase

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For detailed information about acetoacetyl-CoA synthase, go to the full flat file.

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Synonyms

AACS, Acetoacetyl-CoA synthase, Acetoacetyl-CoA synthetase, acetoacetyl-coenzyme A synthase, acetoacetyl-coenzyme A synthesizing enzyme, More, NphT7, nphT7SCL, thiolase superfamily acetoacetyl-CoA synthase

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.194 acetoacetyl-CoA synthase

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Results	in table
41	AA Sequence
5	Application
7	Cloned(Commentary)
1	Expression
6	General Information
6	KM Value [mM]
4	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
9	Organism
1	pH Optimum
9	Protein Variants
1	Purification (Commentary)
2	Reaction
7	Reference
5	Source Tissue
2	Specific Activity [micromol/min/mg]
10	Substrates and Products (Substrate)
2	Subunits
21	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]

General Information

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General Information on EC 2.3.1.194 - acetoacetyl-CoA synthase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

malfunction

Mus musculus

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knockdown of AACS in primary neurons caused decreases in the expression of MAP-2 and NeuN, which are markers of neuronal differentiation, as well as synaptopodin, a marker of spine apparatus

718764

metabolism

2 entries

physiological function

Mus musculus

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acetoacetyl-CoA synthetase is a ketone body-utilizing enzyme for the synthesis of cholesterol and fatty acids, regulation of AACS during neurite outgrowth and physiological role of AACS in neurogenesis, overview. AACS is regulated by SREBP-2 and involved in the normal development of neurons

718764

additional information

2 entries

metabolism

Streptomyces sp.

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the acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily is involved in the mevalonate pathway. Acetoacetyl-CoA is the precursor of 3-hydroxy-3-methylglutaryl-CoA in the mevalonate pathway, which is essential for terpenoid backbone biosynthesis. Acetoacetyl-CoA is also the precursor of poly-3-hydroxybutyrate, a polymer belonging to the polyester class produced by microorganisms

706551

metabolism

Streptomyces sp.

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polyhydroxyalkanoate synthase, PhaC, catalyzes generation of (R)-3-hydroxybutyrate monomers from two acetyl-CoA molecules, and further of short-chain length polyhydroxyalkanoates, PHAs. The malonyl-CoA availability is a limiting factor to synthesis of poly(3-hydroxybutyrate), P(3HB), thus acetoacetyl-CoA synthetase, which is controlling the malonyl-CoA pool, is an important enzyme for increasing the P(3HB) production

714539

additional information

Streptomyces sp.

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alterations in acety-CoA carboxylase activity to optimize the acetyl-CoA/malonyl-CoA ratio might be an effective way to increase poly(3-hydroxybutyrate) production via the AACS-catalyzed paythway

714539

additional information

Mus musculus

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SREBP-2, a key transcription factor of cholesterol synthesis, interacts with the AACS promoter and is increased during neurite outgrowth, and knockdown of SREBP-2 down-regulates the mRNA levels of AACS in Neuro-2a cells

718764