2.3.1.194: acetoacetyl-CoA synthase

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For detailed information about acetoacetyl-CoA synthase, go to the full flat file.

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Synonyms

AACS, Acetoacetyl-CoA synthase, Acetoacetyl-CoA synthetase, acetoacetyl-coenzyme A synthase, acetoacetyl-coenzyme A synthesizing enzyme, More, NphT7, nphT7SCL, thiolase superfamily acetoacetyl-CoA synthase

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.194 acetoacetyl-CoA synthase

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Results	in table
41	AA Sequence
5	Application
7	Cloned(Commentary)
1	Expression
6	General Information
6	KM Value [mM]
4	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
9	Organism
1	pH Optimum
9	Protein Variants
1	Purification (Commentary)
2	Reaction
7	Reference
5	Source Tissue
2	Specific Activity [micromol/min/mg]
10	Substrates and Products (Substrate)
2	Subunits
21	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 2.3.1.194 - acetoacetyl-CoA synthase

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SYSTEMATIC NAME

IUBMB Comments

acetyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating)

The enzyme from the soil bacterium Streptomyces sp. CL190 produces acetoacetyl-CoA to be used for mevalonate production via the mevalonate pathway. Unlike the homologous EC 2.3.1.180 (beta-ketoacyl-[acyl-carrier-protein] synthase III), this enzyme does not accept malonyl-[acyl-carrier-protein] as a substrate.