2.1.2.B2: cytidylate 5-hydroxymethyltransferase

This is an abbreviated version!
For detailed information about cytidylate 5-hydroxymethyltransferase, go to the full flat file.

Reaction

Synonyms

CMP hydroxymethylase, cytidylate hydroxymethylase, MilA, thymidylate synthase

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.2 Hydroxymethyl-, formyl- and related transferases

2.1.2.B2 cytidylate 5-hydroxymethyltransferase

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Results	in table
1	AA Sequence
2	Cloned(Commentary)
1	Cofactor
2	Crystallization (Commentary)
10	General Information
2	kcat/KM [mM/s]
2	KM Value [mM]
6	Natural Substrates/ Products (Substrates)
7	Organism
1	pH Optimum
3	Protein Variants
2	Purification (Commentary)
1	Reaction
4	Reference
15	Substrates and Products (Substrate)
2	Subunits
10	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Turnover Number [1/s]

Crystallization

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Crystallization on EC 2.1.2.B2 - cytidylate 5-hydroxymethyltransferase

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enzyme complexed with various substrates including CMP, dCMP and 5'-hydroxymethyl-CMP, hanging drop vapor diffusion method, using 15% (w/v) polyethylene glycol 3350, 0.08 M lithium sulfate monohydrate and 0.1 M Tris-HCl, pH 8.5

Streptomyces rimofaciens

B4Y380

758390

structures of MilA and its complexes with substrates including CMP, dCMP and hydroxymethyl-CMP. Two residues in the active site of dCMP hydroxymethylase from T4 phage and thymidylate synthase from Escherichia coli, a serine and an arginine, are respectively replaced by an alanine and a lysine, Ala176 and Lys133, in MilA

Streptomyces rimofaciens

B4Y380

758390