2.1.2.B2: cytidylate 5-hydroxymethyltransferase
This is an abbreviated version!
For detailed information about cytidylate 5-hydroxymethyltransferase, go to the full flat file.
Reaction
Synonyms
CMP hydroxymethylase, cytidylate hydroxymethylase, MilA, thymidylate synthase
ECTree
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General Information
General Information on EC 2.1.2.B2 - cytidylate 5-hydroxymethyltransferase
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evolution
metabolism
physiological function
additional information
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since MilA have similar mechanism as CH in hydroxyl group formation, it may belong to the superfamily of thymidylate synthase and cytidylate hydroxymethylase
evolution
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since MilA have similar mechanism as CH in hydroxyl group formation, it may belong to the superfamily of thymidylate synthase and cytidylate hydroxymethylase
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mildiomycin formation pathway catalyzed by MilA and MilB, overview
metabolism
the enzyme is involved in mildiomycin biosynthesis
metabolism
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mildiomycin formation pathway catalyzed by MilA and MilB, overview
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several nucleotide-derived nucleoside antibiotics feature modified bases such as hydroxymethyl pyrimidine in polyoxin, and hydroxymethyl cytosine in mildiomycin. The CMP hydroxymethylase named MilA in the biosynthetic pathway of nucleoside mildiomycin in Streptoverticillum rimofaciens ZJU5119 can convert CMP in vitro in the presence of tetrahydrofolate to 5-hydroxymethyl-CMP that is immediately hydrolyzed into free 5-hydroxymethylcytosine by MilB
physiological function
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several nucleotide-derived nucleoside antibiotics feature modified bases such as hydroxymethyl pyrimidine in polyoxin, and hydroxymethyl cytosine in mildiomycin. The CMP hydroxymethylase named MilA in the biosynthetic pathway of nucleoside mildiomycin in Streptoverticillum rimofaciens ZJU5119 can convert CMP in vitro in the presence of tetrahydrofolate to 5-hydroxymethyl-CMP that is immediately hydrolyzed into free 5-hydroxymethylcytosine by MilB
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six homologous ORFs originally annotated as putative thymidylate synthase are more likely to be CMP hydroxymethylase
additional information
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six homologous ORFs originally annotated as putative thymidylate synthase are more likely to be CMP hydroxymethylase
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