2.1.1.85: protein-histidine N-methyltransferase
This is an abbreviated version!
For detailed information about protein-histidine N-methyltransferase, go to the full flat file.
Reaction
Synonyms
actin His73 nmethyltransferase, actin histidine methyltransferase, actin histidine-N3 methyltransferase, actin-specific histidine methyltransferase, actin-specific histidine N-methyltransferase, actin-specific methyltransferase, methyltransferase, protein (histidine), protein (actin) histidine MTase, protein methylase IV, S-adenosyl methionine:protein-histidine N-methyltransferase, SET domain protein 3, setd3
ECTree
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Substrates Products
Substrates Products on EC 2.1.1.85 - protein-histidine N-methyltransferase
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REACTION DIAGRAM
S-adenosyl-L-methionine + actin L-histidine73
S-adenosyl-L-homocysteine + actin Ntau-methyl-L-histidine73
S-adenosyl-L-methionine + beta-actin L-histidine73
S-adenosyl-L-homocysteine + beta-actin Ntau-methyl-L-histidine73
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?
S-adenosyl-L-methionine + human beta-actin (residues 66-80)
S-adenosyl-L-homocysteine + human beta-actin (residues 66-80) Ntau-methyl-L-histidine
sequence TLKYPIEHGIVTNWD
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?
S-adenosyl-L-methionine + human beta-actin L-histidine73
S-adenosyl-L-homocysteine + protein Ntau-methyl-L-histidine73
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?
S-adenosyl-L-methionine + protein L-histidine
S-adenosyl-L-homocysteine + protein Ntau-methyl-L-histidine
S-adenosyl-L-methionine + protein L-histidine73
S-adenosyl-L-homocysteine + protein Ntau-methyl-L-histidine73
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?
S-adenosyl-L-methionine + synthetic peptide corresponding to residue 66-80 of actin
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?
S-adenosyl-L-methionine + synthetic peptide corresponding to residue 66-88 of beta-actin
?
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?
S-adenosyl-L-methionine + synthetic peptide corresponding to residue 69-77 of actin
S-adenosyl-L-homocysteine + peptide Ntau-methyl-L-histidine
S-adenosyl-L-homocysteine + actin Ntau-methyl-L-histidine73
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?
S-adenosyl-L-methionine + actin L-histidine73
S-adenosyl-L-homocysteine + actin Ntau-methyl-L-histidine73
in a pre-reactive complex the enzyme binds the N3-protonated form of actin His73, and in a post-reactive product complex, the enzyme generates the methylated histidine in an N1-protonated and N3-methylated form
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?
S-adenosyl-L-methionine + actin L-histidine73
S-adenosyl-L-homocysteine + actin Ntau-methyl-L-histidine73
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?
S-adenosyl-L-homocysteine + protein Ntau-methyl-L-histidine
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?
S-adenosyl-L-methionine + protein L-histidine
S-adenosyl-L-homocysteine + protein Ntau-methyl-L-histidine
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specifically methylates histidine residues of actin
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?
S-adenosyl-L-methionine + protein L-histidine
S-adenosyl-L-homocysteine + protein Ntau-methyl-L-histidine
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specifically methylates histidine residues of actin
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?
S-adenosyl-L-methionine + protein L-histidine
S-adenosyl-L-homocysteine + protein Ntau-methyl-L-histidine
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some activity with gluten
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?
S-adenosyl-L-methionine + protein L-histidine
S-adenosyl-L-homocysteine + protein Ntau-methyl-L-histidine
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negligible activity with: bovine serum albumin, fibrinogen, casein, histone type IIA, gelatin, human gamma-globulin
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?
S-adenosyl-L-methionine + protein L-histidine
S-adenosyl-L-homocysteine + protein Ntau-methyl-L-histidine
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naturally occuring actins are poor substrates, due to preexistent methylation at His 73
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?
S-adenosyl-L-methionine + protein L-histidine
S-adenosyl-L-homocysteine + protein Ntau-methyl-L-histidine
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chicken beta-actin expressed in E. coli as a fusion protein with 80 amino acids of an influenza protein, NS1
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?
S-adenosyl-L-homocysteine + peptide Ntau-methyl-L-histidine
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?
S-adenosyl-L-methionine + synthetic peptide corresponding to residue 69-77 of actin
S-adenosyl-L-homocysteine + peptide Ntau-methyl-L-histidine
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Tyr-Pro-Ile-Glu-His-Gly-Ile-Ile-Thr
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no activity with histone H3 L-lysine4 (1-23), histone H3 L-lysine36 (25-47), and beta-actin (66-88) H73A mutant
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additional information
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the enzyme does not methylate histones and shows no activity on actin I71A/W79E double mutations
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additional information
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the enzyme does not methylate histones and shows no activity on actin I71A/W79E double mutations
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additional information
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the enzyme has weak lysine methylation activity on an actin peptide in which the target His73 is substituted by a L-lysine
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additional information
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no activity with human beta-actin mutant H73A, ATP-bound actin or ADP-bound actin
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