2.1.1.254: erythromycin 3''-O-methyltransferase

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For detailed information about erythromycin 3''-O-methyltransferase, go to the full flat file.

Reaction

Synonyms

EryG

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.254 erythromycin 3''-O-methyltransferase

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120	AA Sequence
3	Cloned(Commentary)
4	General Information
2	Natural Substrates/ Products (Substrates)
6	Organism
6	Pathway
3	Reaction
6	Reference
2	Substrates and Products (Substrate)
5	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 2.1.1.254 - erythromycin 3''-O-methyltransferase

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SYSTEMATIC NAME

IUBMB Comments

S-adenosyl-L-methionine:erythromycin C 3''-O-methyltransferase

The enzyme methylates the 3 position of the mycarosyl moiety of erythromycin C, forming the most active form of the antibiotic, erythromycin A. It can also methylate the precursor erythromycin D, forming erythromycin B, which is then converted to erythromycin A by EC 1.14.13.154, erythromycin 12 hydroxylase.