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2.1.1.216: tRNA (guanine26-N2)-dimethyltransferase

This is an abbreviated version!
For detailed information about tRNA (guanine26-N2)-dimethyltransferase, go to the full flat file.

Word Map on EC 2.1.1.216

Reaction

2 S-adenosyl-L-methionine +

guanine26 in tRNA
= 2 S-adenosyl-L-homocysteine +
N2-dimethylguanine26 in tRNA

Synonyms

EC 2.1.1.32, Ta0997, transfer RNA methyltransferase, Trm1, Trm1 methyltransferase, Trm1p, tRNA (guanine(26)-N(2))-dimethyltransferase, tRNA (m22G26)dimethyltransferase, tRNA(guanine-26,N2-N2) methyltransferase, tRNA(guanine26,N2,N2)-dimethyltransferase, tRNA(m22G26)dimethyltransferase, ZC376.5

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.216 tRNA (guanine26-N2)-dimethyltransferase

Natural Substrates Products

Natural Substrates Products on EC 2.1.1.216 - tRNA (guanine26-N2)-dimethyltransferase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2 S-adenosyl-L-methionine + guanine26 in tRNA
2 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNA
show the reaction diagram
2 S-adenosyl-L-methionine + guanine26 in tRNA
2 S-adenosyl-L-homocysteine + N2-dimethylguanine26 tRNA
show the reaction diagram
-
the efficient dimethylation of guanine26 requires the presence of base-pairs C11*G24 and G10*C25 and a variable loop of five bases within a correct 3D-core of the tRNA molecule. These identity elements probably ensure the correct presentation of methylated m2G26 to the enzyme for the attachment of the second methyl group
-
-
?
2 S-adenosyl-L-methionine + guanine26 in tRNALeu(UAG)
2 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNALeu(UAG)
show the reaction diagram
4 S-adenosyl-L-methionine + guanine26 in initiator tRNAMet
4 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in initiator tRNAMet
show the reaction diagram
m2G26 and m22G26 are formed by Trm1
-
-
?
4 S-adenosyl-L-methionine + guanine26 in prolongator tRNAMet
4 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in prolongator tRNAMet
show the reaction diagram
m2G26 and m22G26 are formed by Trm1
-
-
?
4 S-adenosyl-L-methionine + guanine26 in tRNA
4 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNA
show the reaction diagram
4 S-adenosyl-L-methionine + guanine26 in tRNALeuCAA
4 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNALeuCAA
show the reaction diagram
-
-
-
-
?
4 S-adenosyl-L-methionine + guanine26 in tRNALeuTAG
4 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNALeuTAG
show the reaction diagram
-
-
-
-
?
4 S-adenosyl-L-methionine + guanine26 in tRNASerUCA
4 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNASerUCA
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + 2'-O-methylguanine26 in elongator tRNAMet
S-adenosyl-L-homocysteine + 2'-O-dimethylguanine26 in elongator tRNAMet
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 2'-O-methylguanine26 in initiator tRNAMet
S-adenosyl-L-homocysteine + 2'-O-dimethylguanine26 in initiator tRNAMet
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + guanine26 in elongator tRNAMet
S-adenosyl-L-homocysteine + 2'-O-methylguanine26 in elongator tRNAMet
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + guanine26 in initiator tRNAMet
S-adenosyl-L-homocysteine + 2'-O-methylguanine26 in initiator tRNAMet
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + guanine26 in tRNA
S-adenosyl-L-homocysteine + N2-methylguanine26 in tRNA
show the reaction diagram
S-adenosyl-L-methionine + N2-methylguanine26 in tRNA
S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNA
show the reaction diagram