2.1.1.212: 2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase
This is an abbreviated version!
For detailed information about 2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase, go to the full flat file.
Reaction
Synonyms
2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase/isoflavone 4'-O-methyltransferase, 2-hydroxyisoflavanone 4'-O-methyltransferase, HI4'OMT, HI4'OMT/HM3OMT, HI4OMT, HMM1, More, MtIOMT5, S-adenosyl-L-methionine: 2-hydroxyisoflavanone 4'-O-methyltransferase, SAM: 2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase, SAM:2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase
ECTree
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General Information
General Information on EC 2.1.1.212 - 2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase
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evolution
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a synteny block among Cicer arietinum chromosome 6 (inverted), Glycyrrhiza uralensis scaffold 00721 and Medicago truncatula chromosome 4, which includes genes involved in isoflavonoid biosynthesis (7-IOMT, CYP93C and HI4OMT), overview
metabolism
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2,7-dihydroxy-4'-O-methoxy-isoflavanone is converted to formononetin, calycosin and calycosin-7-O-beta-D-glucoside via a series of reactions in the calycosin-7-O-beta-D-glucoside pathway. The 2,7,4'-trihydroxyisoflavanone is probably more easily caught by 2-hydroxyisoflavanone 4'-O-methyltransferase and hence provides more precursors for formononetin than being converted to daidzein, overview
metabolism
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the enzyme is involved in the isoflavonoid biosynthesis together with 2-hydroxyisoflavanone synthase (CYP93C) and isoflavone-7-O-methyltransferase (7-IOMT), forming a cluster on the scaffold of the liquorice genome. The second gene in the cluster encodes the enzyme 2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase/isoflavone 4'-O-methyltransferase, i.e. HI4OMT (ECs 2.1.1.212 and 2.1.1.46), which typically converts daidzein to formononetin or genistein to biochanin A