2.1.1.201: 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase

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For detailed information about 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, go to the full flat file.

Reaction

Synonyms

2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, BoCOQ5-2, BoCOQ5-2 methyltransferase, C-methyltransferase Coq5, COQ5, Coq5 C-methyltransferase, COQ5 methyltransferase, UbiE, ubiquinone biosynthesis O-methyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.201 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase

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Results	in table
17840	AA Sequence
2	Application
5	Cloned(Commentary)
2	Cofactor
1	Crystallization (Commentary)
4	Disease/ Diagnostics
4	Expression
14	General Information
7	Localization
2	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
14	Organism
15	Pathway
8	PDB ID
1	pH Optimum
4	Protein Variants
1	Purification (Commentary)
2	Reaction
14	Reference
7	Source Tissue
6	Substrates and Products (Substrate)
3	Subunits
19	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]

Cloned

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Cloned on EC 2.1.1.201 - 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

BoCOQ5-2 partially complements the yeast coq5 mutant. Escherichia coli cells expressing BoCOQ5-2 exhibit a greater than 3fold increase in total ubiquinone content in comparison with the vector-only control

Brassica oleracea

C6ZH71

706320

expression in Escherichia coli

Saccharomyces cerevisiae

P49017

704388

gene COQ5 or YML110C, recombinant expression of N-terminally His-tagged truncated enzyme Coq5-DELTAN26 in Escherichia coli BL21(DE3), selenomethionine-labelled Coq5 protein is overexpressed in Escherichia coli strain B834 (DE3)

Saccharomyces cerevisiae

P49017

735364

the COQ5 gene, when introduced into Escherichia coli, complements the respiratory deficiency of an ubiE mutant that maps near o251, suggesting that it is the yeast homolog of the ubiE gene product

Saccharomyces cerevisiae

P49017

704387

the gene encoding human COQ5 spans to 26 kb on chromosome 12q24.31 and is comprised of seven exons, HEK-293 cells are co-transfected with the pCOQ5-myc and pCOQ4-V5, expression of a COQ5-GFP construct in HeLa cells, construction of a hybrid yeast-human COQ5 (yhCOQ5) gene by amplifying a 5' segment of yCOQ5, corresponding to the mitochondrial targeting region (encoding aa 1-54) and the 3' of human COQ5

Homo sapiens

Q5HYK3

735704