2.1.1.201: 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase

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For detailed information about 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, go to the full flat file.

Reaction

Synonyms

2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, BoCOQ5-2, BoCOQ5-2 methyltransferase, C-methyltransferase Coq5, COQ5, Coq5 C-methyltransferase, COQ5 methyltransferase, UbiE, ubiquinone biosynthesis O-methyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.201 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase

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Results	in table
17840	AA Sequence
2	Application
5	Cloned(Commentary)
2	Cofactor
1	Crystallization (Commentary)
4	Disease/ Diagnostics
4	Expression
14	General Information
7	Localization
2	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
14	Organism
15	Pathway
8	PDB ID
1	pH Optimum
4	Protein Variants
1	Purification (Commentary)
2	Reaction
14	Reference
7	Source Tissue
6	Substrates and Products (Substrate)
3	Subunits
19	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 2.1.1.201 - 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase

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SYSTEMATIC NAME

IUBMB Comments

S-adenosyl-L-methionine:2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol 5-C-methyltransferase

This enzyme is involved in ubiquinone biosynthesis. Ubiquinones from different organisms have a different number of prenyl units (for example, ubiquinone-6 in Saccharomyces, ubiquinone-9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units. For example, when the COQ5 gene from Saccharomyces cerevisiae is introduced into Escherichia coli, it complements the respiratory deficiency of an ubiE mutant [3]. The bifunctional enzyme from Escherichia coli also catalyses the methylation of demethylmenaquinol-8 (this activity is classified as EC 2.1.1.163) [1].