1.5.8.2: trimethylamine dehydrogenase
This is an abbreviated version!
For detailed information about trimethylamine dehydrogenase, go to the full flat file.
Word Map on EC 1.5.8.2
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1.5.8.2
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flavin
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flavoproteins
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fmn
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iron-sulfur
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semiquinone
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mononucleotide
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methylotrophus
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methylophilus
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dimethylamine
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6-s-cysteinyl
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isoalloxazine
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ferricenium
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flavocytochrome
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nocardioides
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flavinylation
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fmn-binding
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tetramethylammonium
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deflavo
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hyphomicrobium
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analysis
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nutrition
- 1.5.8.2
- flavin
- flavoproteins
- fmn
-
iron-sulfur
- semiquinone
- mononucleotide
- methylotrophus
- methylophilus
- dimethylamine
-
6-s-cysteinyl
- isoalloxazine
- ferricenium
-
flavocytochrome
-
nocardioides
-
flavinylation
-
fmn-binding
- tetramethylammonium
-
deflavo
- hyphomicrobium
- analysis
- nutrition
Reaction
Synonyms
EC 1.5.99.7, More, TMA dehydrogenase, TMADH, TMD, TMDH
ECTree
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General Information
General Information on EC 1.5.8.2 - trimethylamine dehydrogenase
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metabolism
the neutral amine of the substrate binds productively at the pH optimum. The deuterium (kcat/Kamine) value decreases to unity as the pH decreases, suggesting the presence of an alternative pathway at low pH, in which the protonated substrate binds and is then deprotonated by an active-site residue prior to oxidation. The kcat and deuterium kcat values both decrease to limiting values at low pH with similar pKa values. Above pH 10, the relative values of the two isotope effects establish that amine oxidation is about 4 times faster than a subsequent step or steps
metabolism
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the neutral amine of the substrate binds productively at the pH optimum. The deuterium (kcat/Kamine) value decreases to unity as the pH decreases, suggesting the presence of an alternative pathway at low pH, in which the protonated substrate binds and is then deprotonated by an active-site residue prior to oxidation. The kcat and deuterium kcat values both decrease to limiting values at low pH with similar pKa values. Above pH 10, the relative values of the two isotope effects establish that amine oxidation is about 4 times faster than a subsequent step or steps
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