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1.5.8.2: trimethylamine dehydrogenase

This is an abbreviated version!
For detailed information about trimethylamine dehydrogenase, go to the full flat file.

Word Map on EC 1.5.8.2

Reaction

trimethylamine
+
H2O
 +
electron-transfer flavoprotein
=
Dimethylamine
 +
formaldehyde
 +
reduced electron-transfer flavoprotein

Synonyms

EC 1.5.99.7, More, TMA dehydrogenase, TMADH, TMD, TMDH

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.8 With a flavin or flavoprotein as acceptor
                1.5.8.2 trimethylamine dehydrogenase

Inhibitors

Inhibitors on EC 1.5.8.2 - trimethylamine dehydrogenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-phenylcyclopropylamine
-
irreversible inactivation of both wild-type and mutant C30A
1-phenylethylhydrazine
methylotrophic bacterium
-
potent inhibition at very low concentration
2,6-dichlorophenolindophenol
-
-
2-phenylcyclopropylamine
methylotrophic bacterium
-
82% inhibition at 0.1 mM
2-phenylethylhydrazine
methylotrophic bacterium
-
potent inhibition at very low concentration
acetaldehyde
-
noncompetitive inhibition with respect to diethylamine, uncompetitive inhibition with respect to phenazine methosulfate
Ag+
methylotrophic bacterium
-
strong inhibition at 1 mM
benzylhydrazine
methylotrophic bacterium
-
potent inhibition at very low concentration
Betaine hydrochloride
methylotrophic bacterium
-
37% inhibition at 1 mM
choline chloride
methylotrophic bacterium
-
potent inhibition at 1 mM
Co2+
methylotrophic bacterium
-
strong inhibition at 1 mM
Cu2+
methylotrophic bacterium
-
strong inhibition at 1 mM
Diethylamine
-
noncompetitive product inhibition with respect to phenazine methosulfate
diphosphate
-
noncompetitive inhibition to 50% of initial activity with respect to trimethylamine
ethylamine
-
noncompetitive product inhibition with respect to phenazine methosulfate
ferricinium
-
Val334 is involved in binding and initiates a conformational change interrupting the electron transfer between FMN and the [4Fe-4S] cluster
Harmaline
methylotrophic bacterium
-
65% inhibition at 0.1 mM
hexamethylene bis-trimethylammonium chloride
methylotrophic bacterium
-
potent inhibition at 1 mM
Hg2+
methylotrophic bacterium
-
strong inhibition at 1 mM
iodoacetamide
methylotrophic bacterium
-
inhibition at 1 mM
Iproniazid
methylotrophic bacterium
-
potent inhibition at very low concentration
isocarboxazid
methylotrophic bacterium
-
potent inhibition at very low concentration
isopropylhydrazine
methylotrophic bacterium
-
potent inhibition at very low concentration
N,N,N-trimethyl-N-phenylammonium chloride
methylotrophic bacterium
-
potent inhibition at 1 mM
N,N,N-trimethylhydrazonium iodide
methylotrophic bacterium
-
potent inhibition at 1 mM
N-benzyl-N-methylpropargylamine
methylotrophic bacterium
-
27% inhibition at 0.1 mM
N-cyclopropyl-alpha-methylbenzylamine
-
irreversible inactivation of both wild-type and mutant C30A, more potent than 1-phenylcyclopropylamine
N-ethylmaleimide
methylotrophic bacterium
-
inhibition at 1 mM
Ni2+
methylotrophic bacterium
-
strong inhibition at 1 mM
nialamid
methylotrophic bacterium
-
potent inhibition at very low concentration
p-chloromercuribenzoate
methylotrophic bacterium
-
inhibition at 1 mM
phenylhydrazine
Tetramethylammonium chloride
trimethylamine
trimethylsulfomium chloride
methylotrophic bacterium
-
potent inhibition at 1 mM
additional information
-
no inhibition by (dimethylamino)methylene ferrocene, ferrocenedicarboxylic acid, ferrocenemonocarboxylic acid, ferrocenedimathanol, (dimethylamino)methylene ferrocene, ferricyanide, and thionine
-