1.20.1.1: phosphonate dehydrogenase
This is an abbreviated version!
For detailed information about phosphonate dehydrogenase, go to the full flat file.
Word Map on EC 1.20.1.1
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1.20.1.1
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phosphorus
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stutzeri
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hydride
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baeyer-villiger
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biotechnology
-
bvmos
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phenylacetone
-
d-hydroxy
-
synthesis
- 1.20.1.1
- phosphorus
- stutzeri
-
hydride
-
baeyer-villiger
- biotechnology
-
bvmos
- phenylacetone
-
d-hydroxy
- synthesis
Reaction
Synonyms
NAD-dependent phosphite dehydrogenase, NAD:phosphite oxidoreductase, phosphite dehydrogenase, PTDH, PtxD
ECTree
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Substrates Products
Substrates Products on EC 1.20.1.1 - phosphonate dehydrogenase
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REACTION DIAGRAM
hydroxypyruvate + NAD+
pyruvate + NADH
very poor substrate
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?
phosphite + H2O + NAD+
phosphate + NADH + H+
use of phosphite as energy source, regeneration of NADH
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ir
phosphite + H2O + NAD+
phosphate + NADH + H+
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Asp79 is important in orienting Arg237 for proper interaction with phosphite
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-
?
phosphite + H2O + NAD+
phosphate + NADH + H+
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Asp79 is important in orienting Arg237 for proper interaction with phosphite
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-
?
phosphite + H2O + NADP+
phosphate + NADPH + H+
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NADP poorly substitutes for NAD+
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?
phosphite + H2O + NADP+
phosphate + NADPH + H+
NADP poorly substitutes for NAD+
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?
phosphonate + H2O + NAD+
phosphate + NADH
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NADH regeneration system
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ir
phosphonate + H2O + NAD+
phosphate + NADH
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-
-
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ir
phosphonate + H2O + NAD+
phosphate + NADH
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enables growth on phosphonate as sole phosphorous source
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-
ir
phosphonate + H2O + NAD+
phosphate + NADH
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NADH regeneration system
-
-
ir
phosphonate + H2O + NAD+
phosphate + NADH
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NADH regeneration system
-
-
ir
phosphonate + H2O + NAD+
phosphate + NADH
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NADH regeneration system
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-
ir
phosphate + NADPH
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100-fold lower activity than with NAD+
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-
ir
phosphonate + H2O + NADP+
phosphate + NADPH
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NADP+ is a very poor hydride acceptor with the wild type enzyme
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-
ir
phosphonate + H2O + NADP+
phosphate + NADPH
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NADP+ is a very poor hydride acceptor with the wild type enzyme
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-
ir
phosphonate + NAD+ + H2O
phosphate + NADH + H+
Methylorubrum extorquens ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1
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-
-
-
?
phosphonate + NAD+ + H2O
phosphate + NADH + H+
-
-
-
?
phosphonate + NAD+ + H2O
phosphate + NADH + H+
-
-
-
?
?
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-
enzyme does not accept any alternative substrates
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-
?
additional information
?
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-
enzyme does not accept any alternative substrates
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-
?
additional information
?
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-
enzyme does not accept any alternative substrates
-
-
?