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1.14.15.5: corticosterone 18-monooxygenase

This is an abbreviated version!
For detailed information about corticosterone 18-monooxygenase, go to the full flat file.

Word Map on EC 1.14.15.5

Reaction

corticosterone
+ 2 reduced adrenodoxin +
O2
 + 2 H+ =
18-hydroxycorticosterone
 + 2 oxidized adrenodoxin +
H2O

Synonyms

corticosterone 18-hydroxylase, corticosterone methyl oxidase, CYP11B2, cytochrome P450 11B2, oxygenase, corticosterone 18-mono-

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.15.5 corticosterone 18-monooxygenase

Engineering

Engineering on EC 1.14.15.5 - corticosterone 18-monooxygenase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
V386A
the combination of the V386A mutation with the variant CYP11B2 173Arg only slightly reduces the 18-hydroxylase and 18-oxidase activity, whereas the V386A mutation with the CYP11B2 173Lys variant almost abolishes the 18-hydroxylation and 18-oxidation. In both cases the 11-hydroxylase activity is not affected