1.14.15.5: corticosterone 18-monooxygenase

This is an abbreviated version!
For detailed information about corticosterone 18-monooxygenase, go to the full flat file.

Word Map on EC 1.14.15.5

1.14.15.5

aldosterone

18-hydroxycorticosterone

steroid

cyp11b2

glomerulosa

cortisol

hypoaldosteronism

zona

thrive

acth

hyperkalemia

renin

18-hydroxylation

salt-wasting

mineralocorticoid

fasciculata

11-deoxycorticosterone

18-hydroxycortisol

18-oh-corticosterone

fludrocortisone

salt-losing

18-oxocortisol

furosemide

p450aldo

deoxycorticosterone

Reaction

+ 2 reduced adrenodoxin +

+ 2 H+ =

+ 2 oxidized adrenodoxin +

Synonyms

corticosterone 18-hydroxylase, corticosterone methyl oxidase, CYP11B2, cytochrome P450 11B2, oxygenase, corticosterone 18-mono-

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor

1.14.15.5 corticosterone 18-monooxygenase

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6	AA Sequence
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57	Disease/ Diagnostics
3	General Stability
42	Inhibitors
8	Localization
3	Metals/Ions
6	Natural Substrates/ Products (Substrates)
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Reference on EC 1.14.15.5 - corticosterone 18-monooxygenase

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438757

Raman, P.B.; Sharma, D.C.; Dorfman, R.I.

Studies on aldosterone biosynthesis in vitro

Biochemistry

1795-1804

1966

Bos taurus, Cavia porcellus, Ovis aries

4381410

438758

Nomoto, S.; Massa, G.; Mitani, F.; Ishimura, Y.; Miyahara, K.; Toda, K.; Nagano, I; Yamashiro, T.; Ogoshi, S.; Fukata, J.I.; Onishi, S.; Hashimoto, K.; Doi, Y.; Imura, H.; Shizuta, Y.

CMO I deficiency caused by a point mutation in exon 8 of the human CYP11B2 gene encoding steroid 18-hydroxylase (P450C18)

Biochem. Biophys. Res. Commun.

234

382-385

1997

Homo sapiens

9177280

687068

Sethupathi, V.; Vijayakumar, M.; Janakiraman, L.; Nammalwar, B.R.

Congenital hypoaldosteronism

Indian Pediatr.

695-697

2008

Homo sapiens

18723916

744791

Neunzig, J.; Khatri, Y.; Bernhardt, R.

The impact of the clinical CYP11B2 mutation V386A strongly depends on the enzymes genetic background

Endocr. J.

457-461

2017

Homo sapiens (P19099)

28190867