1.14.13.211: rifampicin monooxygenase

This is an abbreviated version!
For detailed information about rifampicin monooxygenase, go to the full flat file.

Reaction

Synonyms

RIF-O, rifampicin monooxygenase, RifMO, rox

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

1.14.13.211 rifampicin monooxygenase

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2	AA Sequence
3	Cloned(Commentary)
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2	Crystallization (Commentary)
6	General Information
4	Natural Substrates/ Products (Substrates)
16	Organism
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2	Protein Variants
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13	Reference
14	Substrates and Products (Substrate)
17	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Crystallization

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Crystallization on EC 1.14.13.211 - rifampicin monooxygenase

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in complex with rifampicin, to 1.8 A resolution. RifMO is a class A flavoprotein monooxygenase and is similar in fold and quaternary structure to MtmOIV and OxyS, in the mithramycin and oxytetracycline biosynthetic pathways, respectively. RifMO dimerizes via the FAD-binding domain to form a bell-shaped homodimer in solution with a maximal dimension of 110 A. The rifampicin naphthoquinone blocks access to the FAD N5 atom

Nocardia farcinica

Q5YTV5

738694

structure of RIFMO in complex with the hydroxylated rifampicin product, to 2.10 A resolution. Structure shows a breach of the ansa aliphatic chain of rifampicin between naphthoquinone C2 and amide N1

Nocardia farcinica

Q5YTV5

764146