1.14.13.211: rifampicin monooxygenase
This is an abbreviated version!
For detailed information about rifampicin monooxygenase, go to the full flat file.
Reaction
Synonyms
RIF-O, rifampicin monooxygenase, RifMO, rox
ECTree
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Engineering
Engineering on EC 1.14.13.211 - rifampicin monooxygenase
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additional information
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the rox gene deletion mutation DELTArox gives no significant influence to the rifampicin resistance of Nocardia farcinica. Transformation with plasmid pKNL027_N05 overexpressing the rox gene markedly raises the rifampicin resistance in the strain with the deletion mutation of the rpoB2 gene as the principal rifampicin resistance determinant. Rifampicin is degraded by the wild-type strain, whereas it remains intact when incubated with the DELTArox strain
additional information
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the rox gene deletion mutation DELTArox gives no significant influence to the rifampicin resistance of Nocardia farcinica. Transformation with plasmid pKNL027_N05 overexpressing the rox gene markedly raises the rifampicin resistance in the strain with the deletion mutation of the rpoB2 gene as the principal rifampicin resistance determinant. Rifampicin is degraded by the wild-type strain, whereas it remains intact when incubated with the DELTArox strain
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