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1.14.11.33: DNA oxidative demethylase

This is an abbreviated version, for detailed information about DNA oxidative demethylase, go to the full flat file.

Reaction

DNA-base-CH3
+
2-oxoglutarate
+
O2
=
DNA-base
+
formaldehyde
+
succinate
+
CO2

Synonyms

1-methyladenine-DNA dioxygenase, ABH1, ABH2, ABH3, AlkB, ALKBH3, alkylated DNA repair protein, alpha-ketoglutarate-dependent dioxygenase ABH1, FTO

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.33 DNA oxidative demethylase

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Results
in table
176
AA Sequence
1
Application
14
Cloned(Commentary)
6
Cofactor
1
Crystallization (Commentary)
95
Disease/ Diagnostics
13
Engineering
25
General Information
1
Inhibitors
10
KCat/KM [mM/s]
13
KM Value [mM]
7
Localization
16
Metals/Ions
24
Natural Substrates/ Products (Substrates)
41
Organism
136
PDB ID
6
pH Optimum
18
Purification (Commentary)
1
Reaction
8
Reaction Type
36
Reference by Title
10
Source Tissue
1
Storage Stability
187
Substrates and Products (Substrate)
22
Synonyms
1
Systematic Name
2
Temperature Optimum [°C]
12
Turnover Number [1/s]
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