1.14.11.33: DNA oxidative demethylase
This is an abbreviated version!
For detailed information about DNA oxidative demethylase, go to the full flat file.
Word Map on EC 1.14.11.33
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1.14.11.33
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demethylation
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3-methylcytosine
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wobble
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1,n6-ethenoadenine
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alkbhs
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2-oxoglutarate-dependent
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dealkylation
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writer
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etheno
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epitranscriptomic
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5-methoxycarbonylmethyluridine
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n1-methyladenosine
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n6-methyladenine
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analysis
- 1.14.11.33
-
demethylation
- 3-methylcytosine
-
wobble
- 1,n6-ethenoadenine
-
alkbhs
-
2-oxoglutarate-dependent
-
dealkylation
-
writer
-
etheno
-
epitranscriptomic
-
5-methoxycarbonylmethyluridine
- n1-methyladenosine
- n6-methyladenine
- analysis
Reaction
Synonyms
1-methyladenine-DNA dioxygenase, ABH1, ABH2, ABH3, AlkB, AlkB homolog 1, ALKBH2, ALKBH3, ALKBH8, alkylated DNA repair protein, alpha-ketoglutarate-dependent dioxygenase ABH1, FTO
ECTree
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Metals Ions
Metals Ions on EC 1.14.11.33 - DNA oxidative demethylase
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Fe2+
Mg2+
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the double-stranded DNA preference of isoform ABH2 is observed only in the presence of magnesium, the presence of magnesium stimulates the activity of isoform ABH2 on double-stranded DNA, but inhibits its activity on single-stranded DNA (maximal effect is observed in the presence of 10 mM MgCl2)
Fe2+
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required for activity
Fe2+
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required for activity, AlkB is a member of the non-heme iron (II) 2-oxoglutarate-dependent dioxygenase superfamily