Sequence of KLK2_RAT
EC Number:3.4.21.35
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Preferential cleavage of Arg-/- bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-/- or Leu-/-. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-/- bonds
Other sequences found for EC No. 3.4.21.35
General information:
Sequence
0 MWLQILSLVL SVGRIDAAPP GQSRIVGGYK CEKNSQPWQV AVINEYLCGG VLIDPSWVIT
60 AAHCYSNNYQ VLLGRNNLFK DEPFAQRRLV RQSFRHPDYI PLIVTNDTEQ PVHDHSNDLM
120 LLHLSEPADI TGGVKVIDLP TKEPKVGSTC LASGWGSTNP SEMVVSHDLQ CVNIHLLSNE
180 KCIETYKDNV TDVMLCAGEM EGGKDTCAGD SGGPLICDGV LQGITSGGAT PCAKPKTPAI
240 YAKLIKFTSW IKKVMKENP
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
310741
Ashley P.L.,MacDonald R.J.
Kallikrein-related mRNAs of the rat submaxillary gland: nucleotide sequences of four distinct types including tonin.
Biochemistry
24
4512-4520
1985
310742
Wines D.R.,Brady J.M.,Pritchett D.B.,Roberts J.L.,MacDonald R.J.
Organization and expression of the rat kallikrein gene family.
J. Biol. Chem.
264
7653-7662
1989
310743
Shai S.Y.,Woodley-Miller C.,Chao J.,Chao L.
Characterization of genes encoding rat tonin and a kallikrein-like serine protease.
Biochemistry
28
5334-5343
1989
310744
Lazure C.,Leduc R.,Seidah N.G.,Thibault G.,Genest J.,Chretien M.
The complete amino acid sequence of rat submaxillary gland tonin does contain the aspartic acid at the active site: confirmation by protein sequence analysis.
Biochem. Cell Biol.
65
321-337
1987
310745
Lazure C.,Leduc R.,Seidah N.G.,Thibault G.,Genest J.,Chretien M.
Amino acid sequence of rat submaxillary tonin reveals similarities to serine proteases.
Nature
307
555-558
1984
310746
Kamada M.,Furuhata N.,Yamaguchi T.,Ikekita M.,Kizuki K.,Moriya H.
Observation of tissue prokallikrein activation by some serine proteases, arginine esterases in rat submandibular gland.
Biochem. Biophys. Res. Commun.
166
231-237
1990
310747
Moreau T.,Brillard-Bourdet M.,Bouhnik J.,Gauthier F.
Protein products of the rat kallikrein gene family. Substrate specificities of kallikrein rK2 (tonin) and kallikrein rK9.
J. Biol. Chem.
267
10045-10051
1992
310748
Fujinaga M.,James M.N.G.
Rat submaxillary gland serine protease, tonin. Structure solution and refinement at 1.8-A resolution.
J. Mol. Biol.
195
373-396
1987
