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2-aminobenzoyl-MISLMKRPPGFSPFRSS(PO3H2)RI-NH2 + H2O
2-aminobenzoyl-MISLM + KRPPGFSPFRSS(PO3H2)RI-NH2
-
-
-
-
?
2-aminobenzoyl-MISLMKRPPGFSPFRSSRI-NH2 + H2O
2-aminobenzoyl-MISLM + KRPPGFSPFRSSRI-NH2
-
-
-
-
?
2-aminobenzoyl-TSVIRRVQ-ethylenediamine + H2O
?
-
-
-
-
?
Abz-ALFSSKQ-EDDnp + H2O
?
-
-
-
-
?
Abz-FLFSSKQ-EDDnp + H2O
?
-
-
-
-
?
Abz-FRSSR-Q-EDDnp + H2O
Abz-FR + SSR-Q-EDDnp
-
-
-
?
Abz-GFSPFRSLRI-Q-EDDnp + H2O
Abz-GFSPFR + SLRI-Q-EDDnp
-
-
-
?
Abz-GFSPFRSSRI-Q-EDDnp + H2O
Abz-GFSPFR + SSRI-Q-EDDnp
-
-
-
?
Abz-GLFSSKQ-EDDnp + H2O
?
-
-
-
-
?
Abz-HLFSSKQ-EDDnp + H2O
?
-
-
-
-
?
Abz-ILFSSKQ-EDDnp + H2O
?
-
-
-
-
?
Abz-KAFSSKQ-EDDnp + H2O
?
-
-
-
-
?
Abz-KFFSSKQ-EDDnp + H2O
?
-
-
-
-
?
Abz-KLFFSK-EDDnp + H2O
Abz-KLF + FSK-EDDnp
-
-
-
-
?
Abz-KLFRSK-EDDnp + H2O
Abz-KLF + RSK-EDDnp
-
-
-
-
?
Abz-KLFSAKQ-EDDnp + H2O
Abz-KLF + SAKQ-EDDnp
-
-
-
-
?
Abz-KLFSGKQ-EDDnp + H2O
Abz-KLF + SGKQ-EDDnp
-
-
-
-
?
Abz-KLFSIKQ-EDDnp + H2O
Abz-KLF + SIKQ-EDDnp
-
-
-
-
?
Abz-KLFSLKQ-EDDnp + H2O
Abz-KLF + SLKQ-EDDnp
-
-
-
-
?
Abz-KLFSNKQ-EDDnp + H2O
Abz-KLF + SNKQ-EDDnp
-
-
-
-
?
Abz-KLFSRKQ-EDDnp + H2O
Abz-KLF + SRKQ-EDDnp
-
-
-
-
?
Abz-KLFSSDQ-EDDnp + H2O
Abz-KLF + SSDQ-EDDnp
-
-
-
-
?
Abz-KLFSSEQ-EDDnp + H2O
Abz-KLF + SSEQ-EDDnp
-
-
-
-
?
Abz-KLFSSGQ-EDDnp + H2O
Abz-KLF + SSGQ-EDDnp
-
-
-
-
?
Abz-KLFSSIQ-EDDnp + H2O
Abz-KLF + SSIQ-EDDnp
-
-
-
-
?
Abz-KLFSSK-EDDnp + H2O
Abz-KLF + SSK-EDDnp
-
-
-
-
?
Abz-KLFSSKQ-EDDnp + H2O
Abz-KLF + SSKQ-EDDnp
-
-
-
-
?
Abz-KLFSSLQ-EDDnp + H2O
Abz-KLF + SSLQ-EDDnp
-
-
-
-
?
Abz-KLFSSNQ-EDDnp + H2O
Abz-KLF + SSNQ-EDDnp
-
-
-
-
?
Abz-KLFSSQQ-EDDnp + H2O
Abz-KLF + SSQQ-EDDnp
-
-
-
-
?
Abz-KLFSSRQ-EDDnp + H2O
Abz-KLF + SSRQ-EDDnp
-
-
-
-
?
Abz-KLFSSSQ-EDDnp + H2O
Abz-KLF + SSSQ-EDDnp
-
-
-
-
?
Abz-KLFSSVQ-EDDnp + H2O
Abz-KLF + SSVQ-EDDnp
-
-
-
-
?
Abz-KLFSVKQ-EDDnp + H2O
Abz-KLF + SVKQ-EDDnp
-
-
-
-
?
Abz-KLFTSK-EDDnp + H2O
Abz-KLF + TSK-EDDnp
-
-
-
-
?
Abz-KLFWSK-EDDnp + H2O
Abz-KLF + WSK-EDDnp
-
-
-
-
?
Abz-KLRSSQ-EDDnp + H2O
?
-
-
-
-
?
Abz-KLYSSK-EDDnp + H2O
?
-
-
-
-
?
Abz-KPFSSKQ-EDDnp + H2O
?
-
-
-
-
?
Abz-KVFSSKQ-EDDnp + H2O
?
-
-
-
-
?
Abz-KYFSSKQ-EDDnp + H2O
?
-
-
-
-
?
Abz-LLFSSKQ-EDDnp + H2O
?
-
-
-
-
?
Abz-MISLMKLP-Q-EDDnp + H2O
Abz-MISLM + KLP-Q-EDDnp
-
-
-
?
Abz-MISLMKRP-Q-EDDnp + H2O
Abz-MISLM + KRP-Q-EDDnp
-
-
-
?
Abz-MISLMKRPPGFSPFRSSRI-NH2 + H2O
Abz-MISLM + KRPPGFSPF + RSSRI-NH2
-
-
-
-
?
Abz-NLFSSKQ-EDDnp + H2O
?
-
-
-
-
?
Abz-NLYRVE-Q-EDDnp + H2O
Abz-NLY + RVE-Q-EDDnp
-
-
-
-
?
Abz-QLFSSKQ-EDDnp + H2O
?
-
-
-
-
?
Abz-RLFSSKQ-EDDnp + H2O
?
-
-
-
-
?
Abz-VLFSSKQ-EDDnp + H2O
?
-
-
-
-
?
Ac-GKAFRR-L12ADT + H2O
?
-
peptide coupled to cytotoxin thapsigarin, L12ADT, as an enzyme-activated prodrug. Enzyme cleaves at R-residue adjacent to L12ADT
-
-
?
acetyl-2-aminohexanoic acid-Arg methyl ester + H2O
acetyl-2-aminohexanoic acid-Arg + methanol
-
-
-
-
?
acetyl-Ala-Arg methyl ester + H2O
acetyl-Ala-Arg + methanol
-
-
-
-
?
acetyl-Ala-Arg-Ala + H2O
acetyl-Ala-Arg + L-alanine
-
-
-
-
?
acetyl-Ala-Arg-Arg methyl ester + H2O
?
-
-
-
-
?
acetyl-Ala-Leu-Arg-p-nitroanilide + H2O
acetyl-Ala-Leu-Arg + p-nitroaniline
-
-
-
-
?
acetyl-Ala-Phe-Arg methyl ester + H2O
acetyl-Ala-Phe-Arg + methanol
-
-
-
-
?
acetyl-Ala-Phe-Arg-Ala + H2O
acetyl-Ala-Phe-Arg + L-alanine
-
-
-
-
?
acetyl-Ala-Phe-Arg-Ala-NH2 + H2O
acetyl-Ala-Phe-Arg + Ala-NH2
-
-
-
-
?
acetyl-Ala-Phe-Arg-p-nitroanilide + H2O
acetyl-Ala-Phe-Arg + p-nitroaniline
-
-
-
-
?
acetyl-Ala-Thr-Arg-p-nitroanilide + H2O
acetyl-Ala-Thr-Arg + p-nitroaniline
-
-
-
-
?
acetyl-Arg methyl ester + H2O
acetyl-Arg + methanol
-
-
-
-
?
acetyl-Arg-Ala-NH2 + H2O
acetyl-Arg + Ala-NH2
-
-
-
-
?
acetyl-Arg-p-nitroanilide + H2O
acetyl-Arg + p-nitroaniline
-
-
-
-
?
acetyl-D-Ala-Arg methyl ester + H2O
acetyl-D-Ala-Arg + methanol
-
-
-
-
?
acetyl-D-Phe-Arg methyl ester + H2O
acetyl-D-Phe-Arg + methanol
-
-
-
-
?
acetyl-Glu-Leu-Arg-p-nitroanilide + H2O
acetyl-Glu-Leu-Arg + p-nitroaniline
-
-
-
-
?
acetyl-Glu-Lys-Arg-p-nitroanilide + H2O
acetyl-Glu-Lys-Arg + p-nitroaniline
-
-
-
-
?
acetyl-Glu-Phe-Arg-p-nitroanilide + H2O
acetyl-Glu-Phe-Arg + p-nitroaniline
-
-
-
-
?
acetyl-Glu-Thr-Arg-p-nitroanilide + H2O
acetyl-Glu-Thr-Arg + p-nitroaniline
-
-
-
-
?
acetyl-Gly-Arg methyl ester + H2O
acetyl-Gly-Arg + methanol
-
-
-
-
?
acetyl-Gly-Arg-Ser-Val-Gln + H2O
acetyl-Gly-Arg + Ser-Val-Gln
-
-
-
?
acetyl-Ile-Arg methyl ester + H2O
acetyl-Ile-Arg + methanol
-
-
-
-
?
acetyl-Leu-Arg methyl ester + H2O
acetyl-Leu-Arg + methanol
-
-
-
-
?
acetyl-Met-Arg methyl ester + H2O
acetyl-Met-Arg + methanol
-
-
-
-
?
acetyl-Phe-Arg ethyl ester + H2O
acetyl-Phe-Arg + ethanol
-
-
-
-
?
acetyl-Phe-Arg methyl ester + H2O
acetyl-Phe-Arg + methanol
acetyl-Phe-Arg-Ala + H2O
acetyl-Phe-Arg + L-alanine
-
-
-
-
?
acetyl-Phe-Arg-p-nitroanilide + H2O
acetyl-Phe-Arg + p-nitroaniline
-
-
-
-
?
acetyl-Phe-Arg-Ser-NH2 + H2O
acetyl-Phe-Arg + Ser-NH2
-
-
-
?
acetyl-Phe-Arg-Ser-Val-Gln + H2O
acetyl-Phe-Arg + Ser-Val-Gln
-
-
-
?
acetyl-Phe-Arg-Ser-Val-NH2 + H2O
acetyl-Phe-Arg + Ser-Val-NH2
-
-
-
?
acetyl-Pro-Arg methyl ester + H2O
acetyl-Pro-Arg + methanol
-
-
-
-
?
acetyl-Pro-Phe-Arg methyl ester + H2O
acetyl-Pro-Phe-Arg + methanol
-
-
-
-
?
acetyl-Pro-Phe-Arg-Ala + H2O
acetyl-Pro-Phe-Arg + L-alanine
-
-
-
-
?
acetyl-Pro-Phe-Arg-Ala-NH2 + H2O
acetyl-Pro-Phe-Arg + Ala-NH2
-
-
-
-
?
acetyl-Pro-Phe-Arg-p-nitroanilide + H2O
acetyl-Pro-Phe-Arg + p-nitroaniline
-
-
-
-
?
acetyl-Trp-2-aminohexanoic acid methyl ester + H2O
?
-
-
-
-
?
acetyl-Trp-Arg methyl ester + H2O
acetyl-Trp-Arg + methanol
-
-
-
-
?
acetyl-Tyr-Arg methyl ester + H2O
acetyl-Tyr-Arg + methanol
-
-
-
-
?
acetyl-Val-Arg methyl ester + H2O
acetyl-Val-Arg + methanol
-
-
-
-
?
Ala-Ala-Arg-7-amido-4-methylcoumarin + H2O
Ala-Ala-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
Ala-Arg-Arg-7-amido-4-methylcoumarin + H2O
Ala-Arg-Arg + 7-amino-4-methylcoumarin
angiotensin I + H2O
?
-
reaction with prostate enzyme, very low reaction with submandibular enzyme
-
-
?
angiotensinogen + H2O
?
-
reaction with prostate enzyme, no reaction with submandibular enzyme
-
-
?
angiotensinogen + H2O
angiotensin
-
-
-
?
benzoyl-Phe-Val-Arg-7-amido-4-methylcoumarin + H2O
benzoyl-Phe-Val-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzoyl-Pro-Phe-Arg-p-nitroanilide + H2O
benzoyl-Pro-Phe-Arg + p-nitroaniline
-
-
-
-
?
benzyloxycarbonyl-Arg methyl ester + H2O
benzyloxycarbonyl-Arg + methanol
benzyloxycarbonyl-Arg-Ala-NH2 + H2O
benzyloxycarbonyl-Arg + Ala-NH2
-
-
-
-
?
benzyloxycarbonyl-Arg-p-nitroanilide + H2O
benzyloxycarbonyl-Arg + p-nitroaniline
-
-
-
-
?
Benzyloxycarbonyl-Lys methyl ester + H2O
Benzyloxycarbonyl-Lys + methanol
-
-
-
-
?
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
?
-
about 30% of the activity with Pro-Phe-Arg-4-methylcoumarin 7-amide
-
-
?
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Phe-Ser-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Phe-Ser-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Pro-Gly-Arg methyl ester + H2O
benzyloxycarbonyl-Pro-Gly-Arg + methanol
-
-
-
-
?
benzyloxycarbonyl-Pro-Phe-Arg methyl ester + H2O
benzyloxycarbonyl-Pro-Phe-Arg + methanol
-
-
-
-
?
benzyloxycarbonyl-Tyr-4-nitrophenyl ester + H2O
benzyloxycarbonyl-Tyr + 4-nitrophenol
-
-
-
-
?
citrated bovine plasma + H2O
?
-
-
-
-
?
citrated dog plasma + H2O
?
-
-
-
-
?
D-Ile-Pro-Arg-4-nitroanilide + H2O
D-Ile-Pro-Arg + 4-nitroaniline
-
weak activity
-
-
?
D-Pro-Phe-Arg-4-methylcoumarin-7-amide + H2O
?
D-Pro-Phe-Arg-4-nitroanilide + H2O
D-Pro-Phe-Arg + 4-nitroaniline
-
weak activity
-
-
?
D-Pro-Phe-Phe-4-methylcoumarin-7-amide + H2O
?
D-Pro-Phe-Phe-7-amido4-methylcoumarin + H2O
D-Pro-Phe-Phe + 7-amino-4-methylcoumarin
-
-
-
-
?
D-Val-Leu-Arg-4-nitroanilide + H2O
D-Val-Leu-Arg + 4-nitroaniline
D-Val-Leu-Arg-7-amido-4-trifluoromethylcoumarin + H2O
D-Val-Leu-Arg + 7-amino-4-trifluoromethylcoumarin
-
-
-
-
?
D-Val-Leu-Arg-p-nitroanilide + H2O
D-Val-Leu-Arg + p-nitroaniline
D-Val-Leu-Lys-4-nitroanilide + H2O
D-Val-Leu-Lys + 4-nitroaniline
DL-Val-Leu-Arg-p-nitroanilide + H2O
DL-Val-Leu-Arg + p-nitroaniline
epithelial sodium channel + H2O
activated epithelial sodium channel + ?
-
-
-
-
?
FSPFRSVQ + H2O
FSPFR + SVQ
-
-
-
?
Gelatin + H2O
?
-
-
-
-
?
Gln-Ala-Arg-7-amido-4-methylcoumarin + H2O
Gln-Ala-Arg + 7-amino-4-methylcoumarin
-
-
-
?
Gly-Pro-Arg-7-amido-4-methylcoumarin + H2O
Gly-Pro-Arg + 7-amino-4-methylcoumarin
-
-
-
?
H-D-Pro-Phe-Arg-7-amido-4-methylcoumarin + H2O
H-D-Pro-Phe-Arg + 7-amino-4-methylcoumarin
-
i.e. S-2302
-
-
?
human high molecular weight kininogen + H2O
?
-
-
-
-
?
insulin-like growth factor binding protein + H2O
?
-
-
-
-
?
insulin-like growth factor binding proteins
?
insulin-like growth factor binding proteins
insulin-like growth factor binding protein fragments
kinin B2 receptor + H2O
?
-
tissue kallikrein directly activates kinin B2 receptor in the absence of kininogen
-
-
?
kininogen + H2O
bradykinin + ?
-
-
-
-
?
kininogen + H2O
bradykinin + kinin
kininogen + H2O
bradykinin + kinin heavy chain + kinin light chain
kininogen + H2O
kallidin + kinin heavy chain + kinin light chain
kininogen + H2O
kinin + ?
kininogen + H2O
kinin + bradykinin
-
-
-
-
?
L-Pro-L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O
L-Pro-L-Phe-L-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
Laminin + H2O
?
-
-
-
-
?
Leu-Leu-Arg-7-amido-4-methylcoumarin + H2O
Leu-Leu-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
low density lipoprotein + H2O
?
-
-
-
?
low molecular weight kininogen + H2O
kallidin + kinin
-
-
-
-
?
low-molecular-weight kininogen + H2O
GMISLM + KRPPGFSPFR + SSRIG
-
KRPPGFSPFR is kallidin
-
?
low-molecular-weight kininogen + H2O
kallidin + kinin
N-alpha-acetyl-Phe-Arg ethyl ester + H2O
N-alpha-acetyl-Phe-Arg + ethanol
-
-
-
-
?
N-alpha-acetyl-Tyr ethyl ester + H2O
N-alpha-acetyl-Tyr + ethanol
N-alpha-benzoyl-L-Arg ethyl ester + H2O
N-alpha-benzoyl-L-Arg + ethanol
N-alpha-benzoyl-L-Arg methyl ester + H2O
N-alpha-benzoyl-L-Arg + methanol
N-alpha-benzoyl-L-citrulline methyl ester + H2O
N-alpha-benzoyl-L-citrulline + methanol
-
-
-
-
?
N-alpha-benzoyl-L-Lys methyl ester + H2O
N-alpha-benzoyl-L-Lys + methanol
N-alpha-benzoyl-L-Orn methyl ester + H2O
N-alpha-benzoyl-L-Orn + methanol
-
-
-
-
?
N-alpha-tosyl-L-arginine methyl ester + H2O
N-alpha-tosyl-L-arginine + methanol
-
-
-
-
?
N-methoxysuccinyl-Arg-Pro-Tyr-4-nitroanilide + H2O
N-methoxysuccinyl-Arg-Pro-Tyr + 4-nitroaniline
-
-
-
-
?
o-aminobenzoyl-AIKFFIRE-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-AIKFF + IRE-N-(2,4-dinitrophenyl)ethylene diamine
-
-
-
?
o-aminobenzoyl-AIKFFQRE-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-AIKFF + QRE-N-(2,4-dinitrophenyl)ethylene diamine
-
-
-
?
o-aminobenzoyl-AIKFFSAE-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-AIKFF + SAE-N-(2,4-dinitrophenyl)ethylene diamine
-
-
-
?
o-aminobenzoyl-AIKFFSKE-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-AIKFF + SKE-N-(2,4-dinitrophenyl)ethylene diamine
-
-
-
?
o-aminobenzoyl-AIKFFSPE-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-AIKFF + SPE-N-(2,4-dinitrophenyl)ethylene diamine
-
-
-
?
o-aminobenzoyl-AIKFFSRE-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-AIKFF + SRE-N-(2,4-dinitrophenyl)ethylene diamine
-
-
-
?
o-aminobenzoyl-AIKFFSRQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-AIKFF + SRQ-N-(2,4-dinitrophenyl)ethylene diamine
-
substrate sequence is derived from the kallistatin reactive centre loop sequence
-
?
o-aminobenzoyl-AIKFFSSE-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-AIKFF + SSE-N-(2,4-dinitrophenyl)ethylene diamine
-
-
-
?
o-aminobenzoyl-AIKFFTRE-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-AIKFF + TRE-N-(2,4-dinitrophenyl)ethylene diamine
-
-
-
?
o-aminobenzoyl-FRAPR-N-(2,4-dinitrophenyl)ethylene diamine + H2O
?
o-aminobenzoyl-FRLVR-N-(2,4-dinitrophenyl)ethylene diamine + H2O
?
o-aminobenzoyl-FRSSR-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-FR + SSR-N-(2,4-dinitrophenyl)ethylene diamine
o-aminobenzoyl-FRSVQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-FR + SVQ-N-(2,4-dinitrophenyl)ethylene diamine
o-aminobenzoyl-GFSPF-4-(aminocyclohexyl)alanine-SSRPQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
?
-
synthetic internally quenched fluorescent peptides with substitution for a non-natural amino acid, sequence is based on the human kininogen sequence at the C-terminal region of bradykinin
-
-
?
o-aminobenzoyl-GFSPF-4-(aminomethyl)-N-isopropylphenylalanine-SSRPQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
?
-
synthetic internally quenched fluorescent peptides with substitution for a non-natural amino acid, sequence is based on the human kininogen sequence at the C-terminal region of bradykinin
-
-
?
o-aminobenzoyl-GFSPF-4-(aminomethyl)phenylalanine-SSRPQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
?
-
synthetic internally quenched fluorescent peptides with substitution for a non-natural amino acid, sequence is based on the human kininogen sequence at the C-terminal region of bradykinin
-
-
?
o-aminobenzoyl-GFSPF-4-piperidinylalanine-SSRPQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
?
-
synthetic internally quenched fluorescent peptides with substitution for a non-natural amino acid, sequence is based on the human kininogen sequence at the C-terminal region of bradykinin
-
-
?
o-aminobenzoyl-GFSPF-Nim-(dimethyl)histidine-SSRPQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
?
-
synthetic internally quenched fluorescent peptides with substitution for a non-natural amino acid, sequence is based on the human kininogen sequence at the C-terminal region of bradykinin
-
-
?
o-aminobenzoyl-GFSPFRAPRVQ-ethylenediamine 2,4-dinitrophenol + H2O
o-aminobenzoyl-GFSPFR + APRVQ-ethylenediamine 2,4-dinitrophenol + o-aminobenzoyl-GFSPF + RAPRVQ-ethylenediamine 2,4-dinitrophenol
o-aminobenzoyl-GFSPFRSSRIGEIKEEQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-GFSPFR + SSRIGEIKEEQ-N-(2,4-dinitrophenyl)ethylene diamine
o-aminobenzoyl-GFSPFRSSRQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-GFSPFR + SSRQ-N-(2,4-dinitrophenyl)ethylene diamine
o-aminobenzoyl-GFSPFRSVQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-GFSPFR + SVQ-N-(2,4-dinitrophenyl)ethylene diamine
o-aminobenzoyl-GFSPFRSVQVMKYEGSQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-GFSPFR + SVQVMKYEGSQ-N-(2,4-dinitrophenyl)ethylene diamine
o-aminobenzoyl-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol + H2O
o-aminobenzoyl-GFSPFR + SVTVQ-ethylenediamine 2,4-dinitrophenol
o-aminobenzoyl-LMKRP-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-LM + KRP-N-(2,4-dinitrophenyl)ethylene diamine
o-aminobenzoyl-LPRTMFIQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
?
-
shortened, quenched fluorescent substrate, synthesized based on Bauhinia ungulata factor Xa inhibitor reactive sequence site
-
-
?
o-aminobenzoyl-LPRTMQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
?
-
shortened, quenched fluorescent substrate, synthesized based on Bauhinia ungulata factor Xa inhibitor reactive sequence site
-
-
?
o-aminobenzoyl-MTEMARRPPGFSPFRSVTVQ-NH2 + H2O
o-aminobenzoyl-MTEMAR + RPPGFSPFR + SVTVQ-NH2
o-aminobenzoyl-MTEMARRPQ-ethylenediamine 2,4-dinitrophenol + H2O
o-aminobenzoyl-MTEMAR + RPQ-ethylenediamine 2,4-dinitrophenol
o-aminobenzoyl-MTSVIRRPPGFSPFRAPRV-NH2 + H2O
des[Arg9] bradykinin + ?
-
preferential hydrolysis of Phe-Arg compared with Arg-Ala bond, preferential release of des[Arg9] bradykinin
-
-
?
o-aminobenzoyl-MTSVIRRPPGFSPFRAPRV-NH2 + H2O
o-aminobenzoyl-MTSVIR + RPPGFSPFR + APRV-NH2
o-aminobenzoyl-MTSVIRRPQ-ethylenediamine 2,4-dinitrophenol + H2O
o-aminobenzoyl-MTSVIR + RPQ-ethylenediamine 2,4-dinitrophenol
o-aminobenzoyl-Phe-4-(aminomethyl)phenylalanine-Ser-Arg-Gln-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-Phe-4-(aminomethyl)phenylalanine-Ser-Arg + Gln-N-(2,4-dinitrophenyl)ethylene diamine
-
synthetic internally quenched fluorescent peptides with substitution for a non-natural amino acid, sequence is based on the human kininogen sequence at the C-terminal region of bradykinin
-
-
?
o-aminobenzoyl-Phe-Arg-Arg--ethylenediamine 2,4-dinitrophenol + H2O
o-aminobenzoyl-Phe-Arg + Arg-ethylenediamine 2,4-dinitrophenol
-
slow hydrolysis
-
-
?
o-aminobenzoyl-Phe-Arg-Arg-ethylenediamine 2,4-dinitrophenol + H2O
o-aminobenzoyl-Phe-Arg + Arg-ethylenediamine 2,4-dinitrophenol
o-aminobenzoyl-Phe-Arg-Lys-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol + H2O
o-aminobenzoyl-Phe-Arg + Lys-ethylenediamine 2,4-dinitrophenol
o-aminobenzoyl-Phe-Nim-(dimethyl)histidine-Ser-Arg-Gln-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-Phe-Nim-(dimethyl)histidine-Ser-Arg + Gln-N-(2,4-dinitrophenyl)ethylene diamine
-
synthetic internally quenched fluorescent peptides with substitution for a non-natural amino acid, sequence is based on the human kininogen sequence at the C-terminal region of bradykinin
-
-
?
o-aminobenzoyl-QPLGMISLMKRP-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-QPLGMISLM + KRP-N-(2,4-dinitrophenyl)ethylene diamine
o-aminobenzoyl-QPLGQTSLMKRP-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-QPLGQTSLM + KRP-N-(2,4-dinitrophenyl)ethylene diamine
o-aminobenzoyl-SVIRRVQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
?
o-aminobenzoyl-TSVIRRPQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
?
-
-
-
-
?
o-aminobenzoyl-VMIAALPRTMFIQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
?
o-aminobenzoyl-VMIAALPRTMQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
?
PFRSVQ + H2O
PFR + SVQ
-
-
-
?
Phe-Arg-Ser-Val-Gln + H2O
Phe-Arg + Ser-Val-Gln
-
-
-
?
Phe-Ser-Arg-7-amido-4-methylcoumarin + H2O
Phe-Ser-Arg + 7-amino-4-methylcoumarin
-
-
-
?
poly-L-Arg + H2O
?
-
-
-
-
?
polypeptide + H2O
peptides
precursor of atrial natriuretic factor + H2O
natriuretic factor
-
-
-
?
pro-collagenase + H2O
collagease
-
-
-
?
pro-insulin + H2O
insulin + insulin signal peptide
-
-
-
?
pro-interleukin-1beta + H2O
interleukin-1beta + ?
-
reaction catalyzed by mK13
-
-
?
Pro-Phe-Arg-4-methylcoumarin 7-amide + H2O
?
Pro-Phe-Arg-7-amido-4-methylcoumarin + H2O
Pro-Phe-Arg + 7-amino-4-methylcoumarin
Pro-Phe-Arg-Arg-7-amido-4-methylcoumarin + H2O
Pro-Phe-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
pro-renin + H2O
renin
-
-
-
?
pro-urokinase + H2O
urokinase
-
-
-
-
?
prolactin + H2O
lactin + ?
-
three cleavage sites between Arg174-Arg175, Lys185-Phe186 and Arg188-Cys189
-
-
?
protein C inhibitor + H2O
?
-
-
-
-
?
QAR-7-amido-4-methylcoumarin + H2O
QAR + 7-amino-4-methylcoumarin
-
-
-
?
RPPGFSPFRSVQ + H2O
RPPGFSPFR + SVQ
-
-
-
?
salmine + H2O
?
-
-
-
-
?
semenogelin I + H2O
KGISSQY + SNTE
-
-
-
?
semenogelin I + H2O
semenogelin I fragments
-
-
-
-
?
semenogelin II + H2O
semenogelin II fragments
-
-
-
-
?
single-chain tissue-type plasminogen activator + H2O
?
somatostatin + H2O
?
-
-
-
-
?
Substance P + H2O
?
-
-
-
-
?
succinyl-Val-Pro-Phe-thiobenzyl ester + H2O
succinyl-Val-Pro-Phe + phenylmethanethiol
-
-
-
-
?
tert-butyloxycarbonyl-Gln-Ala-Arg-4-methylcoumarin 7-amide + H2O
?
-
about 15% of the activity with Pro-Phe-Arg-4-methylcoumarin 7-amide
-
-
?
tert-butyloxycarbonyl-Phe-Ser-Arg-7-amido-4-methylcoumarin + H2O
?
-
about 50% of the activity with Pro-Phe-Arg-4-methylcoumarin 7-amide
-
-
?
tert-butyloxycarbonyl-Val-Pro-Arg-7-amido-4-methylcoumarin + H2O
?
-
about 20% of the activity with Pro-Phe-Arg-4-methylcoumarin 7-amide
-
-
?
Tosyl-Arg methyl ester + H2O
Tosyl-Arg + methanol
tosyl-Gly-Pro-Arg-p-nitroanilide + H2O
tosyl-Gly-Pro-Arg + p-nitroaniline
-
-
-
-
?
Val-Leu-Arg-4-nitroanilide + H2O
Val-Leu-Arg + 4-nitroaniline
-
tracheobronchial epithelial cells grown at the air/liquid interface
-
-
?
Val-Pro-Arg-7-amido-4-methylcoumarin + H2O
Val-Pro-Arg + 7-amino-4-methylcoumarin
Val-Pro-Arg-Arg-7-amido-4-methylcoumarin + H2O
Val-Pro-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
vascular endothelial growth factor 164 + H2O
?
-
-
-
-
?
vascular endothelial growth factor-165 + H2O
?
-
-
-
-
?
Vasoactive intestinal peptide + H2O
?
-
-
-
?
VPR-7-amido-4-methylcoumarin + H2O
VPR + 7-amino-4-methylcoumarin
-
-
-
?
WDDDDNLLVCDVPIR + H2O
WDDDDNL + LVCDVPIR
-
-
-
-
?
Z-L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O
?
-
-
-
-
?
zymogen of prostate-specific antigen + H2O
prostate-specific antigen + APLILSR
-
-
-
-
?
zymogen of urokinase-type plasminogen activator + H2O
urokinase-type plasminogen activator
-
activation of inactive zymogen to mature active enzyme
-
?
additional information
?
-
acetyl-Phe-Arg methyl ester + H2O
acetyl-Phe-Arg + methanol
-
-
-
-
?
acetyl-Phe-Arg methyl ester + H2O
acetyl-Phe-Arg + methanol
-
-
-
-
?
Ala-Arg-Arg-7-amido-4-methylcoumarin + H2O
Ala-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
Ala-Arg-Arg-7-amido-4-methylcoumarin + H2O
Ala-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Arg methyl ester + H2O
benzyloxycarbonyl-Arg + methanol
-
-
-
-
?
benzyloxycarbonyl-Arg methyl ester + H2O
benzyloxycarbonyl-Arg + methanol
-
-
-
-
?
D-Pro-Phe-Arg-4-methylcoumarin-7-amide + H2O
?
-
-
-
-
?
D-Pro-Phe-Arg-4-methylcoumarin-7-amide + H2O
?
-
-
-
-
?
D-Pro-Phe-Arg-4-methylcoumarin-7-amide + H2O
?
-
-
-
-
?
D-Pro-Phe-Phe-4-methylcoumarin-7-amide + H2O
?
-
-
-
-
?
D-Pro-Phe-Phe-4-methylcoumarin-7-amide + H2O
?
-
-
-
-
?
D-Pro-Phe-Phe-4-methylcoumarin-7-amide + H2O
?
-
-
-
-
?
D-Val-Leu-Arg-4-nitroanilide + H2O
D-Val-Leu-Arg + 4-nitroaniline
-
-
-
-
?
D-Val-Leu-Arg-4-nitroanilide + H2O
D-Val-Leu-Arg + 4-nitroaniline
-
-
-
-
?
D-Val-Leu-Arg-4-nitroanilide + H2O
D-Val-Leu-Arg + 4-nitroaniline
-
also known as S2266, a chromogenic substrate for tissue kallikrein
-
-
?
D-Val-Leu-Arg-4-nitroanilide + H2O
D-Val-Leu-Arg + 4-nitroaniline
-
S-2266, selective tissue kallikrein substrate
-
-
?
D-Val-Leu-Arg-4-nitroanilide + H2O
D-Val-Leu-Arg + 4-nitroaniline
-
-
-
-
?
D-Val-Leu-Arg-p-nitroanilide + H2O
D-Val-Leu-Arg + p-nitroaniline
-
-
-
-
?
D-Val-Leu-Arg-p-nitroanilide + H2O
D-Val-Leu-Arg + p-nitroaniline
-
-
-
-
?
D-Val-Leu-Arg-p-nitroanilide + H2O
D-Val-Leu-Arg + p-nitroaniline
-
weak activity
-
-
?
D-Val-Leu-Arg-p-nitroanilide + H2O
D-Val-Leu-Arg + p-nitroaniline
-
-
-
-
?
D-Val-Leu-Arg-p-nitroanilide + H2O
D-Val-Leu-Arg + p-nitroaniline
-
-
-
-
?
D-Val-Leu-Arg-p-nitroanilide + H2O
D-Val-Leu-Arg + p-nitroaniline
-
-
-
-
?
D-Val-Leu-Lys-4-nitroanilide + H2O
D-Val-Leu-Lys + 4-nitroaniline
-
weak activity
-
-
?
D-Val-Leu-Lys-4-nitroanilide + H2O
D-Val-Leu-Lys + 4-nitroaniline
-
-
-
-
?
D-Val-Leu-Lys-4-nitroanilide + H2O
D-Val-Leu-Lys + 4-nitroaniline
-
-
-
-
?
DL-Val-Leu-Arg-p-nitroanilide + H2O
DL-Val-Leu-Arg + p-nitroaniline
-
-
-
-
?
DL-Val-Leu-Arg-p-nitroanilide + H2O
DL-Val-Leu-Arg + p-nitroaniline
-
-
-
-
?
Fibronectin + H2O
?
-
-
-
-
?
Fibronectin + H2O
?
-
-
-
-
?
insulin-like growth factor binding proteins
?
-
i.e. IGFBP
-
-
?
insulin-like growth factor binding proteins
?
-
degradation of IGFBP 2-5
-
-
?
insulin-like growth factor binding proteins
?
-
enhancement of IGF bioavailability, role in tumor progression
-
-
?
insulin-like growth factor binding proteins
insulin-like growth factor binding protein fragments
-
i.e. IGFBP
identification of products
?
insulin-like growth factor binding proteins
insulin-like growth factor binding protein fragments
-
degradation of IGFBP 2-5
identification of products
?
kininogen + H2O
bradykinin + kinin
-
high-molecular weight kininogen
-
?
kininogen + H2O
bradykinin + kinin
-
3 additional claevage sites at Arg427, Arg437, and Arg457
-
?
kininogen + H2O
bradykinin + kinin heavy chain + kinin light chain
-
important role in bradykinin release in seminal fluid
-
?
kininogen + H2O
bradykinin + kinin heavy chain + kinin light chain
-
high-molecular weight kininogen
-
?
kininogen + H2O
bradykinin + kinin heavy chain + kinin light chain
-
3 additional cleavage sites at Arg427, Arg437, and Arg457
-
?
kininogen + H2O
bradykinin + kinin heavy chain + kinin light chain
-
cleavage of rat kininogen at Arg-Arg and Arg-Ser
-
?
kininogen + H2O
kallidin + kinin heavy chain + kinin light chain
-
-
-
?
kininogen + H2O
kallidin + kinin heavy chain + kinin light chain
best substrate
-
-
?
kininogen + H2O
kallidin + kinin heavy chain + kinin light chain
enzyme is involved in inflammation, sepsis, pancreatitis, bone metabolism, heart disease, renal disease, and cancer through release of kallidin, i.e. Lys-bradykinin
-
-
?
kininogen + H2O
kinin + ?
-
-
-
?
kininogen + H2O
kinin + ?
-
-
-
?
kininogen + H2O
kinin + ?
-
-
-
?
kininogen + H2O
kinin + ?
-
-
-
?
kininogen + H2O
kinin + ?
-
-
-
?
kininogen + H2O
kinin + ?
-
-
-
?
kininogen + H2O
kinin + ?
-
-
-
-
?
kininogen + H2O
kinin + ?
-
high molecular weight kininogen from human and rat
-
-
?
kininogen + H2O
kinin + ?
-
high-molecular weight kininogen
-
-
?
kininogen + H2O
kinin + ?
-
acts preferentially in low molecular weight kininogen
-
-
?
kininogen + H2O
kinin + ?
-
-
-
-
?
kininogen + H2O
kinin + ?
-
-
-
?
kininogen + H2O
kinin + ?
-
-
-
?
kininogen + H2O
kinin + ?
-
-
-
-
?
kininogen + H2O
kinin + ?
-
wild-type and recombinant enzyme
-
-
?
kininogen + H2O
kinin + ?
-
high molecular weight kininogen from human and rat
-
?
kininogen + H2O
kinin + ?
-
rat low molecular weight kininogen and bovine low molecular weight kininogen, T-kininogen
-
?
kininogen + H2O
kinin + ?
-
-
-
?
kininogen + H2O
kinin + ?
-
-
-
-
?
low-molecular-weight kininogen + H2O
kallidin + kinin
-
-
-
?
low-molecular-weight kininogen + H2O
kallidin + kinin
-
-
-
?
low-molecular-weight kininogen + H2O
kallidin + kinin
-
-
-
?
low-molecular-weight kininogen + H2O
kallidin + kinin
-
-
-
?
low-molecular-weight kininogen + H2O
kallidin + kinin
-
-
-
?
low-molecular-weight kininogen + H2O
kallidin + kinin
-
-
-
?
low-molecular-weight kininogen + H2O
kallidin + kinin
-
-
-
?
low-molecular-weight kininogen + H2O
kallidin + kinin
-
-
-
?
low-molecular-weight kininogen + H2O
kallidin + kinin
-
-
-
-
?
low-molecular-weight kininogen + H2O
kallidin + kinin
-
kallidin is Lys-bradykinin
?
low-molecular-weight kininogen + H2O
kallidin + kinin
-
-
kallidin is Lys-bradykinin
?
low-molecular-weight kininogen + H2O
kallidin + kinin
-
-
kallidin is Lys-bradykinin
?
low-molecular-weight kininogen + H2O
kallidin + kinin
-
kallidin is Lys-bradykinin
?
low-molecular-weight kininogen + H2O
kallidin + kinin
-
human
-
?
low-molecular-weight kininogen + H2O
kallidin + kinin
cleavage sequence and sites
kallidin is Lys-bradykinin
?
low-molecular-weight kininogen + H2O
kallidin + kinin
-
-
-
?
low-molecular-weight kininogen + H2O
kallidin + kinin
-
-
-
?
low-molecular-weight kininogen + H2O
kallidin + kinin
-
-
-
?
low-molecular-weight kininogen + H2O
kallidin + kinin
-
-
-
?
low-molecular-weight kininogen + H2O
kallidin + kinin
-
-
-
?
low-molecular-weight kininogen + H2O
kallidin + kinin
-
-
-
-
?
low-molecular-weight kininogen + H2O
kallidin + kinin
-
bovine or human
-
?
low-molecular-weight kininogen + H2O
kallidin + kinin
-
-
-
?
N-alpha-acetyl-Tyr ethyl ester + H2O
N-alpha-acetyl-Tyr + ethanol
-
-
-
-
?
N-alpha-acetyl-Tyr ethyl ester + H2O
N-alpha-acetyl-Tyr + ethanol
-
-
-
-
?
N-alpha-benzoyl-L-Arg ethyl ester + H2O
N-alpha-benzoyl-L-Arg + ethanol
-
-
-
-
?
N-alpha-benzoyl-L-Arg ethyl ester + H2O
N-alpha-benzoyl-L-Arg + ethanol
-
-
-
-
?
N-alpha-benzoyl-L-Arg methyl ester + H2O
N-alpha-benzoyl-L-Arg + methanol
-
-
-
-
?
N-alpha-benzoyl-L-Arg methyl ester + H2O
N-alpha-benzoyl-L-Arg + methanol
-
-
-
-
?
N-alpha-benzoyl-L-Lys methyl ester + H2O
N-alpha-benzoyl-L-Lys + methanol
-
-
-
-
?
N-alpha-benzoyl-L-Lys methyl ester + H2O
N-alpha-benzoyl-L-Lys + methanol
-
-
-
-
?
o-aminobenzoyl-FRAPR-N-(2,4-dinitrophenyl)ethylene diamine + H2O
?
-
-
-
-
?
o-aminobenzoyl-FRAPR-N-(2,4-dinitrophenyl)ethylene diamine + H2O
?
-
-
-
-
?
o-aminobenzoyl-FRLVR-N-(2,4-dinitrophenyl)ethylene diamine + H2O
?
-
-
-
-
?
o-aminobenzoyl-FRLVR-N-(2,4-dinitrophenyl)ethylene diamine + H2O
?
-
-
-
-
?
o-aminobenzoyl-FRSSR-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-FR + SSR-N-(2,4-dinitrophenyl)ethylene diamine
-
sequence spanning the scissile Arg-Ser bond in human kininogen
-
?
o-aminobenzoyl-FRSSR-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-FR + SSR-N-(2,4-dinitrophenyl)ethylene diamine
-
sequence spanning the scissile Arg-Ser bond in human kininogen
-
?
o-aminobenzoyl-FRSVQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-FR + SVQ-N-(2,4-dinitrophenyl)ethylene diamine
-
sequence spanning the scissile Arg-Ser bond in bovine kininogen
-
?
o-aminobenzoyl-FRSVQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-FR + SVQ-N-(2,4-dinitrophenyl)ethylene diamine
-
sequence spanning the scissile Arg-Ser bond in bovine kininogen
-
?
o-aminobenzoyl-GFSPFRAPRVQ-ethylenediamine 2,4-dinitrophenol + H2O
o-aminobenzoyl-GFSPFR + APRVQ-ethylenediamine 2,4-dinitrophenol + o-aminobenzoyl-GFSPF + RAPRVQ-ethylenediamine 2,4-dinitrophenol
-
preferentially hydrolyzed at Phe-Arg bond compared with Phe-Arg
-
-
?
o-aminobenzoyl-GFSPFRAPRVQ-ethylenediamine 2,4-dinitrophenol + H2O
o-aminobenzoyl-GFSPFR + APRVQ-ethylenediamine 2,4-dinitrophenol + o-aminobenzoyl-GFSPF + RAPRVQ-ethylenediamine 2,4-dinitrophenol
-
preferentially hydrolyzed at Phe-Arg bond compared with Phe-Arg
-
-
?
o-aminobenzoyl-GFSPFRAPRVQ-ethylenediamine 2,4-dinitrophenol + H2O
o-aminobenzoyl-GFSPFR + APRVQ-ethylenediamine 2,4-dinitrophenol + o-aminobenzoyl-GFSPF + RAPRVQ-ethylenediamine 2,4-dinitrophenol
-
preferentially hydrolyzed at Phe-Arg bond compared with Phe-Arg
-
-
?
o-aminobenzoyl-GFSPFRSSRIGEIKEEQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-GFSPFR + SSRIGEIKEEQ-N-(2,4-dinitrophenyl)ethylene diamine
-
sequence spanning the scissile Arg-Ser bond in human kininogen
-
?
o-aminobenzoyl-GFSPFRSSRIGEIKEEQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-GFSPFR + SSRIGEIKEEQ-N-(2,4-dinitrophenyl)ethylene diamine
-
sequence spanning the scissile Arg-Ser bond in human kininogen
-
?
o-aminobenzoyl-GFSPFRSSRQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-GFSPFR + SSRQ-N-(2,4-dinitrophenyl)ethylene diamine
-
sequence spanning the scissile Arg-Ser bond in human kininogen
-
?
o-aminobenzoyl-GFSPFRSSRQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-GFSPFR + SSRQ-N-(2,4-dinitrophenyl)ethylene diamine
-
sequence spanning the scissile Arg-Ser bond in human kininogen
-
?
o-aminobenzoyl-GFSPFRSVQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-GFSPFR + SVQ-N-(2,4-dinitrophenyl)ethylene diamine
-
sequence spanning the scissile Arg-Ser bond in bovine kininogen
-
?
o-aminobenzoyl-GFSPFRSVQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-GFSPFR + SVQ-N-(2,4-dinitrophenyl)ethylene diamine
-
sequence spanning the scissile Arg-Ser bond in bovine kininogen
-
?
o-aminobenzoyl-GFSPFRSVQVMKYEGSQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-GFSPFR + SVQVMKYEGSQ-N-(2,4-dinitrophenyl)ethylene diamine
-
sequence spanning the scissile Arg-Ser bond in bovine kininogen
-
?
o-aminobenzoyl-GFSPFRSVQVMKYEGSQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-GFSPFR + SVQVMKYEGSQ-N-(2,4-dinitrophenyl)ethylene diamine
-
sequence spanning the scissile Arg-Ser bond in bovine kininogen
-
?
o-aminobenzoyl-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol + H2O
o-aminobenzoyl-GFSPFR + SVTVQ-ethylenediamine 2,4-dinitrophenol
-
-
-
-
?
o-aminobenzoyl-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol + H2O
o-aminobenzoyl-GFSPFR + SVTVQ-ethylenediamine 2,4-dinitrophenol
-
-
-
-
?
o-aminobenzoyl-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol + H2O
o-aminobenzoyl-GFSPFR + SVTVQ-ethylenediamine 2,4-dinitrophenol
-
-
-
-
?
o-aminobenzoyl-LMKRP-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-LM + KRP-N-(2,4-dinitrophenyl)ethylene diamine
-
-
-
-
?
o-aminobenzoyl-LMKRP-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-LM + KRP-N-(2,4-dinitrophenyl)ethylene diamine
-
low activity
-
?
o-aminobenzoyl-LMKRP-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-LM + KRP-N-(2,4-dinitrophenyl)ethylene diamine
-
sequence spanning the scissile Met-Lys bond in human and bovine kininogen
-
?
o-aminobenzoyl-LMKRP-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-LM + KRP-N-(2,4-dinitrophenyl)ethylene diamine
-
low activity
-
?
o-aminobenzoyl-MTEMARRPPGFSPFRSVTVQ-NH2 + H2O
o-aminobenzoyl-MTEMAR + RPPGFSPFR + SVTVQ-NH2
-
-
RPPGFSPFR is bradykinin
-
?
o-aminobenzoyl-MTEMARRPPGFSPFRSVTVQ-NH2 + H2O
o-aminobenzoyl-MTEMAR + RPPGFSPFR + SVTVQ-NH2
-
-
RPPGFSPFR is bradykinin
-
?
o-aminobenzoyl-MTEMARRPPGFSPFRSVTVQ-NH2 + H2O
o-aminobenzoyl-MTEMAR + RPPGFSPFR + SVTVQ-NH2
-
-
RPPGFSPFR is bradykinin
-
?
o-aminobenzoyl-MTEMARRPQ-ethylenediamine 2,4-dinitrophenol + H2O
o-aminobenzoyl-MTEMAR + RPQ-ethylenediamine 2,4-dinitrophenol
-
-
-
-
?
o-aminobenzoyl-MTEMARRPQ-ethylenediamine 2,4-dinitrophenol + H2O
o-aminobenzoyl-MTEMAR + RPQ-ethylenediamine 2,4-dinitrophenol
-
-
-
-
?
o-aminobenzoyl-MTEMARRPQ-ethylenediamine 2,4-dinitrophenol + H2O
o-aminobenzoyl-MTEMAR + RPQ-ethylenediamine 2,4-dinitrophenol
-
-
-
-
?
o-aminobenzoyl-MTSVIRRPPGFSPFRAPRV-NH2 + H2O
o-aminobenzoyl-MTSVIR + RPPGFSPFR + APRV-NH2
-
-
RPPGFSPFR is bradykinin
-
?
o-aminobenzoyl-MTSVIRRPPGFSPFRAPRV-NH2 + H2O
o-aminobenzoyl-MTSVIR + RPPGFSPFR + APRV-NH2
-
-
RPPGFSPFR is bradykinin
-
?
o-aminobenzoyl-MTSVIRRPQ-ethylenediamine 2,4-dinitrophenol + H2O
o-aminobenzoyl-MTSVIR + RPQ-ethylenediamine 2,4-dinitrophenol
-
slow hydrolysis
-
-
?
o-aminobenzoyl-MTSVIRRPQ-ethylenediamine 2,4-dinitrophenol + H2O
o-aminobenzoyl-MTSVIR + RPQ-ethylenediamine 2,4-dinitrophenol
-
slow hydrolysis
-
-
?
o-aminobenzoyl-MTSVIRRPQ-ethylenediamine 2,4-dinitrophenol + H2O
o-aminobenzoyl-MTSVIR + RPQ-ethylenediamine 2,4-dinitrophenol
-
slow hydrolysis
-
-
?
o-aminobenzoyl-Phe-Arg-Arg-ethylenediamine 2,4-dinitrophenol + H2O
o-aminobenzoyl-Phe-Arg + Arg-ethylenediamine 2,4-dinitrophenol
-
slow hydrolysis
-
-
?
o-aminobenzoyl-Phe-Arg-Arg-ethylenediamine 2,4-dinitrophenol + H2O
o-aminobenzoyl-Phe-Arg + Arg-ethylenediamine 2,4-dinitrophenol
-
slow hydrolysis
-
-
?
o-aminobenzoyl-Phe-Arg-Lys-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol + H2O
o-aminobenzoyl-Phe-Arg + Lys-ethylenediamine 2,4-dinitrophenol
-
slow hydrolysis
-
-
?
o-aminobenzoyl-Phe-Arg-Lys-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol + H2O
o-aminobenzoyl-Phe-Arg + Lys-ethylenediamine 2,4-dinitrophenol
-
slow hydrolysis
-
-
?
o-aminobenzoyl-Phe-Arg-Lys-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol + H2O
o-aminobenzoyl-Phe-Arg + Lys-ethylenediamine 2,4-dinitrophenol
-
slow hydrolysis
-
-
?
o-aminobenzoyl-QPLGMISLMKRP-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-QPLGMISLM + KRP-N-(2,4-dinitrophenyl)ethylene diamine
-
sequence spanning the scissile Met-Lys bond in human kininogen
-
?
o-aminobenzoyl-QPLGMISLMKRP-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-QPLGMISLM + KRP-N-(2,4-dinitrophenyl)ethylene diamine
-
sequence spanning the scissile Met-Lys bond in human kininogen
-
?
o-aminobenzoyl-QPLGQTSLMKRP-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-QPLGQTSLM + KRP-N-(2,4-dinitrophenyl)ethylene diamine
-
sequence spanning the scissile Met-Lys bond in bovine kininogen
-
?
o-aminobenzoyl-QPLGQTSLMKRP-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-QPLGQTSLM + KRP-N-(2,4-dinitrophenyl)ethylene diamine
-
sequence spanning the scissile Met-Lys bond in bovine kininogen
-
?
o-aminobenzoyl-SVIRRVQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
?
-
-
-
-
?
o-aminobenzoyl-SVIRRVQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
?
-
-
-
-
?
o-aminobenzoyl-VMIAALPRTMFIQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
?
-
low activity
-
-
?
o-aminobenzoyl-VMIAALPRTMFIQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
?
-
quenched fluorescent substrate, synthesized based on Bauhinia ungulata factor Xa inhibitor reactive sequence site
-
-
?
o-aminobenzoyl-VMIAALPRTMQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
?
-
low activity
-
-
?
o-aminobenzoyl-VMIAALPRTMQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
?
-
quenched fluorescent substrate, synthesized based on Bauhinia ungulata factor Xa inhibitor reactive sequence site
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
?
polypeptide + H2O
peptides
-
-
?
polypeptide + H2O
peptides
-
S1' and S2' subsites of the enzyme play a determinant role in the recognition and hydrolysis of substrates
-
?
polypeptide + H2O
peptides
-
serine at position P1' and arginine at position P2' result in high activity
-
?
polypeptide + H2O
peptides
-
serine at position P1' and arginine at position P2' results in high activity
-
?
polypeptide + H2O
peptides
implicated in processing of growth factrors and peptide hormones
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
Pro-Phe-Arg-4-methylcoumarin 7-amide + H2O
?
-
-
-
-
?
Pro-Phe-Arg-4-methylcoumarin 7-amide + H2O
?
-
-
-
-
?
Pro-Phe-Arg-7-amido-4-methylcoumarin + H2O
Pro-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
Pro-Phe-Arg-7-amido-4-methylcoumarin + H2O
Pro-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
?
Pro-Phe-Arg-7-amido-4-methylcoumarin + H2O
Pro-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
Pro-Phe-Arg-7-amido-4-methylcoumarin + H2O
Pro-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
Pro-Phe-Arg-7-amido-4-methylcoumarin + H2O
Pro-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
Pro-Phe-Arg-7-amido-4-methylcoumarin + H2O
Pro-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
S-2266 + H2O
?
-
i.e. H-D-Val-Leu-Arg-4-nitroanilide
-
-
?
single-chain tissue-type plasminogen activator + H2O
?
-
-
-
-
?
single-chain tissue-type plasminogen activator + H2O
?
-
glandular kallikrein 24 may play a role in degradation of extracellular matrix proteins in the interstitial area surrounding the Leydig cells of the adult mouse testis, due not only to its own activity, but also to that of plasmin produced by the single-chain tissue-type plasminogen activator-converting activity of glandular kallikrein 24
-
-
?
Tosyl-Arg methyl ester + H2O
Tosyl-Arg + methanol
-
-
-
-
?
Tosyl-Arg methyl ester + H2O
Tosyl-Arg + methanol
-
-
-
-
?
Tosyl-Arg methyl ester + H2O
Tosyl-Arg + methanol
-
-
-
-
?
Val-Pro-Arg-7-amido-4-methylcoumarin + H2O
Val-Pro-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
Val-Pro-Arg-7-amido-4-methylcoumarin + H2O
Val-Pro-Arg + 7-amino-4-methylcoumarin
-
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
substrate specificity study
-
-
?
additional information
?
-
-
substrate specificity study
-
-
?
additional information
?
-
-
no activity with substrate o-aminobenzoyl-FXSRQ-N-(2,4-dinitrophenyl)ethylene diamine harboring at position X a non-natural amino acid like 4-guanidine phenylalanine, 3-pyridylalanine, 4-(aminomethyl)cyclohexylalanine, 4-(aminomethyl)-N-isopropylphenylalanine, 4-piperidinylalanine, and 4-(aminocyclohexyl)alanine
-
-
?
additional information
?
-
-
K1, sustrate specificty of S1 subsite, accepts both Arg and Phe
-
-
?
additional information
?
-
-
no activity with substrate o-aminobenzoyl-GFSPFXSSRPQ-N-(2,4-dinitrophenyl)ethylene diamine harboring at position X a non-natural amino acid like 4-guanidine phenylalanine, 3-pyridylalanine, and 4-(aminomethyl)cyclohexylalanine
-
-
?
additional information
?
-
-
substrate specificty study by phage display
-
-
?
additional information
?
-
-
the enzyme is implicated in the pathology of various inflammatory disorders, the enzyme is an attractive target for therapeutic intervention in diseases such as asthma, pancreatitis and rheumatoid arthritis
-
-
?
additional information
?
-
-
likely the physiological activator of the zymogen form of prostate-specific antigen in the prostate
-
-
?
additional information
?
-
-
involved in prostate cancer development
-
-
?
additional information
?
-
-
involved in blood pressure regulation and inflammation processes
-
-
?
additional information
?
-
-
decrease in activity of tissue kallikrein results from a genetic mutation in humans and is associated with a newly discovered form of arterial dysfunction characterized by an inward remodeling of the brachial artery, which is not adapted to a chronic increase in wall shear stress
-
-
?
additional information
?
-
-
tissue kallikrein 4 regulates the structure and functions of the tumor-associated urokinase-type plasminogen activator receptor
-
-
?
additional information
?
-
-
tissue kallikrein plays an important role in the airways by processing the pro-form of the epidermal growth factor to mature epidermal growth factor in airway submucosal gland cells. The activity of tissue kallikrein is regulated by hyaluronan. Tissue kallikrein is inhibited in the presence of native hyaluronan in the airway and in the submucosal gland duct. Hyaluronan depolymerization is expected to cause activation of tissue kallikrein, release of epidermal growth factor and signaling of epidermal growth factor receptor and to lead to hypertrophy of tracheal submucosal gland cells and hyperplasia as well as mucus hypersecretion with subsequent airflow obstruction
-
-
?
additional information
?
-
-
tissue kallikreins may be causally involved in carcinogenesis, particularly in tumor metastasis and invasion, and thus, may represent attractive drug targets to consider for therapeutic intervention
-
-
?
additional information
?
-
the enzyme cleaves synthetic peptides after arginine but not lysine residues. It does not cleave chymotrypsin
-
-
?
additional information
?
-
-
tissue kallikrein stimulates capillary tube formation and promotes cell migration of cultured endothelial cells, expression of human tissue kallikrein in rat heart reduces infarct size after myocardial infarction, tissue kallikrein inhibits GSK-3beta activity and stimulates vascular endothelial growth factor and vascular endothelial growth factor receptor-2 expression in cultured endothelial cells
-
-
?
additional information
?
-
-
KLK1 can release des-(Arg9)-Lys-bradykinin (KRPPGFSPF) directly from human kininogen, if S391 is phosphorylated
-
-
?
additional information
?
-
-
KLK1 shows substrate specificity with Tyr and Arg preferred at P1 and Ser at P1'
-
-
?
additional information
?
-
KLK1 shows substrate specificity with Tyr and Arg preferred at P1 and Ser at P1'
-
-
?
additional information
?
-
the enzyme cleaves preferentially after arginine
-
-
?
additional information
?
-
-
the enzyme cleaves preferentially after arginine
-
-
?
additional information
?
-
-
kallikrein 24 may play a role in the degradation of extracellular matrix proteins in the interstitial area surrounding the Leydig cells of the adult mouse testis
-
-
?
additional information
?
-
-
substrate specificity study
-
-
?
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(4-amidino-phenyl)-methane-sulfonyl fluoride
2.5 mM, complete inhibition
(tris[2-carboxyethyl] phosphine) and dihydro-lipoic acid
-
13% residual activity at 3 mM
4-(2-aminoethyl)benzenesulfonyl fluoride
-
is an active-site-directed covalent inhibitor
acetyl-D-Lys-L-Phe-L-Arg-D-Arg-L-Gln-N-(2,4-dinitrophenyl)ethylene diamine
-
-
acetyl-D-Lys-L-Phe-L-Arg-D-Arg-L-Gln-NH2
-
-
acetyl-D-Lys-L-Phe-L-Arg-D-Arg-NH2
-
-
acetyl-D-Lys-L-Phe-L-Arg-L-Leu-L-Glu-NH2
-
-
acetyl-Lys-Phe-Phe-Pro-Leu-Glu-NH2
-
leader compound for design of specific inhibitors of K1; weak inhibition
Al3+
-
linear mixed inhibition
Bauhinia bauhinioides trypsin inhibitor II
-
i.e. BbTI-II; N-terminal sequence of the protein is SVVVDTNGQPVSNGADAYYLV
-
beta-mercaptoethanol
-
65% residual activity at 15 mM
Ca2+
-
linear competitive
D-Pro-Phe-Arg-chloromethane
-
is an active-site-directed covalent inhibitor
dihydrolipoate
-
35% residual activity at 3 mM
diisopropyl fluorophosphate
diisopropylfluorophosphate
-
2.0 mM, complete inhibition of hydrolysis of Pro-Phe-Arg-4-methylcoumarin-7-amide
dithiothreitol
-
complete inhibition at 3 mM
EGFR inhibitor
-
blocks tissue kallikrein's skin wound healing effect
-
epidermal growth factor receptor inhibitor
-
-
-
fukugetin
-
mixed-type inhibitor
glutathione
-
16% residual activity at 15 mM
hK11-specific monoclonal antibody
up to 40% inhibition
-
hyaluronic acid
-
binds to the enzyme in vivo
indolacryloyl imidazole
-
-
Nalpha-p-tosyl-L-lysine chloromethyl ketone
-
0.1 mM, 10% inhibition of hydrolysis of Pro-Phe-Arg-4-methylcoumarin-7-amide
Nalpha-p-tosyl-L-phenylalanine chloromethyl ketone
-
0.1 mM, 5% inhibition of hydrolysis of Pro-Phe-Arg-4-methylcoumarin-7-amide
o-aminobenzoyl-AIKFFARE-N-(2,4-dinitrophenyl)ethylene diamine
-
compound gets poorly hydrolyzed as substrate and is a competitive inhibitor
o-aminobenzoyl-AIKFFERE-N-(2,4-dinitrophenyl)ethylene diamine
-
compound gets poorly hydrolyzed as substrate and is a competitive inhibitor
o-aminobenzoyl-AIKFFKRE-N-(2,4-dinitrophenyl)ethylene diamine
-
compound gets poorly hydrolyzed as substrate and is a competitive inhibitor
o-aminobenzoyl-AIKFFLRE-N-(2,4-dinitrophenyl)ethylene diamine
-
compound gets poorly hydrolyzed as substrate and is a competitive inhibitor
o-aminobenzoyl-AIKFFNRE-N-(2,4-dinitrophenyl)ethylene diamine
-
compound gets poorly hydrolyzed as substrate and is a competitive inhibitor
o-aminobenzoyl-AIKFFPRE-N-(2,4-dinitrophenyl)ethylene diamine
-
-
o-aminobenzoyl-AIKFFRRE-N-(2,4-dinitrophenyl)ethylene diamine
-
compound gets poorly hydrolyzed as substrate and is a competitive inhibitor
o-aminobenzoyl-AIKFFSEE-N-(2,4-dinitrophenyl)ethylene diamine
-
compound gets poorly hydrolyzed as substrate and is a competitive inhibitor
o-aminobenzoyl-AIKFFSIE-N-(2,4-dinitrophenyl)ethylene diamine
-
compound gets poorly hydrolyzed as substrate and is a competitive inhibitor
o-aminobenzoyl-AIKFFSLE-N-(2,4-dinitrophenyl)ethylene diamine
-
compound gets poorly hydrolyzed as substrate and is a competitive inhibitor
o-aminobenzoyl-AIKFFSNE-N-(2,4-dinitrophenyl)ethylene diamine
-
compound gets poorly hydrolyzed as substrate and is a competitive inhibitor
o-aminobenzoyl-AIKFFSQE-N-(2,4-dinitrophenyl)ethylene diamine
-
compound gets poorly hydrolyzed as substrate and is a competitive inhibitor
o-aminobenzoyl-AIKFFSTE-N-(2,4-dinitrophenyl)ethylene diamine
-
compound gets poorly hydrolyzed as substrate and is a competitive inhibitor
o-aminobenzoyl-AIKFFSVE-N-(2,4-dinitrophenyl)ethylene diamine
-
compound gets poorly hydrolyzed as substrate and is a competitive inhibitor
o-aminobenzoyl-AIKFFVRE-N-(2,4-dinitrophenyl)ethylene diamine
-
compound gets poorly hydrolyzed as substrate and is a competitive inhibitor
o-aminobenzoyl-D-Lys-L-Phe-L-Arg-D-Arg-L-Gln-N-(2,4-dinitrophenyl)ethylene diamine
-
-
o-aminobenzoyl-D-Lys-L-Phe-L-Arg-L-Pro-L-Arg-L-Gln N-(2,4-dinitrophenyl)ethylene diamine
-
-
o-aminobenzoyl-D-Lys-L-Phe-L-Phe-D-Arg-L-Gln-N-(2,4-dinitrophenyl)ethylene diamine
-
-
o-aminobenzoyl-D-Lys-L-Phe-L-Phe-L-Pro-L-Arg-L-Gln N-(2,4-dinitrophenyl)ethylene diamine
-
-
o-aminobenzoyl-D-Lys-L-Phe-L-Phe-L-Pro-L-Leu-L-Glu N-(2,4-dinitrophenyl)ethylene diamine
-
-
o-aminobenzoyl-F-4-(aminomethyl)cyclohexylalanine-SRQ-N-(2,4-dinitrophenyl)ethylene diamine
-
K1, highly specific
o-aminobenzoyl-TSVIRRPQ-ethylenediamine
-
-
p-nitrophenyl p'-guanidinobenzoate
-
-
pancratic inhibitor
-
-
-
pepstatin
-
0.01 mM, 10% inhibition of hydrolysis of Pro-Phe-Arg-4-methylcoumarin-7-amide
phenylmethylsulfonyl fluoride
protease inhibitor-6
-
from prostate, increased expression in prostate carcinoma; intracellular serine protease inhibitor with both antitrypsin and antichymotrypsin activity; rapid complex formation with the enzyme, involved in neoplastic progression
-
recombinant alpha1-antichymotrypsin
-
generation of selective inhibitors based on substrates selected from a pentapeptide phage-display library and transplanted to the reactive-site loop of alpha1-antichymotrypsin. Engineered alpha1-antichymotrypsins with peptides RGR-SE and ER-VSP are inhibitory and specific to enzyme.
-
serpin A1
about 40% residual activity at 0.002 mM
-
serpin F2
about 50% residual activity at 0.002 mM
-
Soybean trypsin inhibitor
-
tissue kallikrein-binding protein
-
rapidly forms a covalent complex with tissue kallikrein
-
tosyl-L-Lys-chloromethylketone
-
-
alpha1-antitrypsin
-
-
-
alpha1-antitrypsin
-
slowly binds to tissue kallikrein and suppresses its activity
-
antipain
-
weak
antipain
-
0.1 mM, 90% inhibition of hydrolysis of Pro-Phe-Arg-4-methylcoumarin-7-amide
antipain
-
wild-type and recombinant enzyme
Aprotinin
-
-
Aprotinin
up to 40% inhibition
Aprotinin
-
attenuates high-glucose stimulated expression of KLK1
Aprotinin
-
0.1 mM, 55% inhibition of hydrolysis of Pro-Phe-Arg-4-methylcoumarin-7-amide
Aprotinin
-
wild-type and recombinant enzyme
Aprotinin
-
tissue kallikrein is inactivated by incubation with 5fold molar excess of aprotinin at 37°C for 1 h
Aprotinin
-
blocks increase of DU145 cell migration and invasion by tissue kallikrein
Aprotinin
-
delays skin wound healing
benzamidine
-
-
benzamidine
-
1 mM, 80% inhibition of hydrolysis of Pro-Phe-Arg-4-methylcoumarin-7-amide
chymostatin
-
-
chymostatin
-
0.01 mM, 5% inhibition of hydrolysis of Pro-Phe-Arg-4-methylcoumarin-7-amide
diisopropyl fluorophosphate
-
-
diisopropyl fluorophosphate
-
-
diisopropyl fluorophosphate
-
at a slow rate
diisopropyl fluorophosphate
-
-
DX-2300
-
DX-2300 is a fully human antibody that inhibits KLK1 via a competitive inhibition mechanism. Completely inhibits KLK1-like activity in urine and saliva, inhibits KLK1-like activity by 70% in bronchoalveolar lavage fluid. Inability of DX-2300 to bind either KLK1 covalently modified with 4-(2-aminoethyl)benzenesulfonyl fluoride or D-Pro-Phe-Arg-chloromethane, thus DX-2300 binds at or near the active site of the enzyme. DX-2300 blocks oxidative-stress-induced epidermal-growth-factor receptor activation and downstream mucus cell proliferation and hypersecretion, which is mediated by KLK1. DX-2300 is a potent and specific inhibitor of KLK1 that is efficacious in in vitro and in vivo models of airway disease
-
DX-2300
-
completely inhibits KLK1-like activity in urine. In an allergic sheep model of asthma, inhalation of either 1 or 5 mg of DX-2300 inhibits high-molecular mass kininogen-induced bronchoconstriction by 49 and 68%, respectively
-
icatibant
-
blocks decrease of isoproterenol-induced cardiac hypertrophy and fibrosis by overexpressed tissue kallikrein in transgenic rats
icatibant
-
minimally affects increase of DU145 cell migration and invasion by tissue kallikrein
icatibant
-
blocks tissue kallikrein's skin wound healing effect
kallikrein antibody
-
-
-
kallikrein antibody
-
-
-
kallistatin
-
complex formation, highly specific; kinetics; serine protease inhibitor, i.e. serpin, with unique P1 Phe; wild-type human kallistatin and mutants with amino acid substitutions at each P1, P2, or P3 residue, inhibitory potentials, overview
-
kallistatin
-
complex formation, highly specific; inhibitor protein mutants with amino acid substitutions of basic residues at a heparin binding site, which is essential for inhibition of kallikrein; positively charged loop on the surface of kallistatin enhances inhibition of tissue kallikrein by acting as a secondary binding site for kallikrein, model, chimeric mutants; serine protease inhibitor, i.e. serpin, with unique P1 Phe
-
kallistatin
-
irreversible inhibitor
-
leupeptin
-
weak
leupeptin
-
0.1 mM, about 75% inhibition of hydrolysis of Pro-Phe-Arg-4-methylcoumarin-7-amide; 0.2 mM, 85% inhibition of hydrolysis of Pro-Phe-Arg-4-methylcoumarin-7-amide
leupeptin
-
wild-type and recombinant enzyme
Na+
-
inhibits amidase activity
phenylmethylsulfonyl fluoride
about 50% residual activity at 2.5 mM
phenylmethylsulfonyl fluoride
-
-
PMSF
-
-
Protein C inhibitor
cleaves the inhibitor at Arg354-Ser355 without inactivating it; covalent complex formation with K2
-
Protein C inhibitor
-
-
-
Protein C inhibitor
-
covalent complex formation with K2
-
Soybean trypsin inhibitor
-
kallikrein B is inhibited, kallikrein A not
-
Soybean trypsin inhibitor
-
weak
-
Soybean trypsin inhibitor
-
at high concentrations
-
Soybean trypsin inhibitor
-
no inhibition
-
Soybean trypsin inhibitor
-
-
-
Soybean trypsin inhibitor
-
no inhibition
-
Trasylol
-
-
Zn2+
-
-
Zn2+
-
allosteric inhibition
Zn2+
about 20% residual activity at 0.5 mM
additional information
-
no inhibition by Bauhinia bauhinioides trypsin inhibitor I
-
additional information
-
Zn2+-dependent small-molecule competitive inhibitor
-
additional information
-
not affected by heparin
-
additional information
-
ascorbate is devoid of inactivating potential
-
additional information
-
cardiac glycosides can dramatically suppress the transcription of KLKs
-
additional information
not inhibited by serpin A3
-
additional information
-
not inhibited by serpin A3
-
additional information
-
not inhibited by interleukin-1beta-converting enzyme inhibitors
-
additional information
-
DX-2300 is a fully human antibody, it does not inhibit the KLK1-like activity in mouse urine
-
additional information
-
kinin has little effect on increase of DU145 cell migration and invasion by tissue kallikrein. Tissue kallikrein-induced cell migration and invasion are abolished by inhibition of PAR1 using a pharmacological inhibitor or RNA interference. The effect of tissue kallikrein on cell migration and invasion are also blocked by inhibitors of protein kinase C, c-Src, matrix metalloproteinase, EGFR and extracellular signal-regulated kinase
-
additional information
-
neutralizing tissue kallikrein antibody delays skin wound healing
-
additional information
-
no inhibition by Bauhinia bauhinioides trypsin inhibitor I
-
additional information
-
no inhibition by Bauhinia ungulata factor Xa inhibitor, and Bauhinia variegata trypsin inhibitor
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.005
2-aminobenzoyl-TSVIRRVQ-ethylenediamine
-
-
-
0.0043
Abz-ALFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.0032
Abz-FLFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.0015
Abz-FRSSR-Q-EDDnp
pH and temperature not specified in the publication
0.00036
Abz-GFSPFRSLRI-Q-EDDnp
pH and temperature not specified in the publication
0.0002
Abz-GFSPFRSSRI-Q-EDDnp
pH and temperature not specified in the publication
0.0062
Abz-GLFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.0034
Abz-HLFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.0027
Abz-ILFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.0035
Abz-KAFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.003
Abz-KFFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.0016
Abz-KLFFSK-EDDnp
-
at pH 7.5 and 37°C
0.0006
Abz-KLFRSK-EDDnp
-
at pH 7.5 and 37°C
0.0062
Abz-KLFSAKQ-EDDnp
-
at pH 7.5 and 37°C
0.0027
Abz-KLFSGKQ-EDDnp
-
at pH 7.5 and 37°C
0.0027
Abz-KLFSIKQ-EDDnp
-
at pH 7.5 and 37°C
0.0037
Abz-KLFSLKQ-EDDnp
-
at pH 7.5 and 37°C
0.0023
Abz-KLFSNKQ-EDDnp
-
at pH 7.5 and 37°C
0.0015
Abz-KLFSRKQ-EDDnp
-
at pH 7.5 and 37°C
0.0032
Abz-KLFSSDQ-EDDnp
-
at pH 7.5 and 37°C
0.0127
Abz-KLFSSEQ-EDDnp
-
at pH 7.5 and 37°C
0.0016
Abz-KLFSSGQ-EDDnp
-
at pH 7.5 and 37°C
0.0033
Abz-KLFSSIQ-EDDnp
-
at pH 7.5 and 37°C
0.0018
Abz-KLFSSK-EDDnp
-
at pH 7.5 and 37°C
0.0018
Abz-KLFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.0032
Abz-KLFSSLQ-EDDnp
-
at pH 7.5 and 37°C
0.0045
Abz-KLFSSNQ-EDDnp
-
at pH 7.5 and 37°C
0.0043
Abz-KLFSSQQ-EDDnp
-
at pH 7.5 and 37°C
0.0016
Abz-KLFSSRQ-EDDnp
-
at pH 7.5 and 37°C
0.0059
Abz-KLFSSSQ-EDDnp
-
at pH 7.5 and 37°C
0.0104
Abz-KLFSSVQ-EDDnp
-
at pH 7.5 and 37°C
0.0027
Abz-KLFSVKQ-EDDnp
-
at pH 7.5 and 37°C
0.0027
Abz-KLFTSK-EDDnp
-
at pH 7.5 and 37°C
0.0024
Abz-KLFWSK-EDDnp
-
at pH 7.5 and 37°C
0.00062 - 0.00065
Abz-KLRSSQ-EDDnp
0.0034
Abz-KLYSSK-EDDnp
-
at pH 7.5 and 37°C
0.0025
Abz-KPFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.0019
Abz-KVFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.0027
Abz-KYFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.0046
Abz-LLFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.009
Abz-MISLMKLP-Q-EDDnp
pH and temperature not specified in the publication
0.0007
Abz-MISLMKRP-Q-EDDnp
pH and temperature not specified in the publication
0.0017
Abz-NLFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.0052
Abz-QLFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.0041
Abz-RLFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.0021
Abz-VLFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.08
acetyl-2-aminohexanoic acid-Arg methyl ester
-
-
0.6 - 1.14
acetyl-Ala-Arg methyl ester
8.6
acetyl-Ala-Arg-Ala
-
pH 8.0, 25°C
-
0.222
acetyl-Ala-Leu-Arg-p-nitroanilide
-
pH 8.5, 37°C
0.035
acetyl-Ala-Phe-Arg methyl ester
-
pH 8.0, 25°C
0.17
acetyl-Ala-Phe-Arg-Ala
-
pH 8.0, 25°C
0.11
acetyl-Ala-Phe-Arg-p-nitroanilide
-
pH 8.0, 25°C
0.571
acetyl-Ala-Thr-Arg-p-nitroanilide
-
pH 8.5, 37°C
4.1
acetyl-Arg methyl ester
-
pH 8.0, 25°C
16
acetyl-Arg p-nitroanilide
-
pH 8.0, 25°C
14
acetyl-Arg-Ala-NH2
-
pH 8.0, 25°C
2.5
acetyl-D-Ala-Arg methyl ester
-
pH 9.0, 25°C
0.95
acetyl-D-Phe-Arg methyl ester
-
pH 9.0, 25°C
0.849
acetyl-Glu-Leu-Arg-p-nitroanilide
-
pH 8.5, 37°C
0.291
acetyl-Glu-Lys-Arg-p-nitroanilide
-
pH 8.5, 37°C
0.765
acetyl-Glu-Phe-Arg-p-nitroanilide
-
pH 8.5, 37°C
0.929
acetyl-Glu-Thr-Arg-p-nitroanilide
-
pH 8.5, 37°C
0.77
acetyl-Gly-Arg methyl ester
-
pH 9.0, 25°C
26
acetyl-Gly-Arg-Ser-Val-Gln
-
pH 9.0, 25°C
0.199
acetyl-Ile-Arg methyl ester
-
pH 9.0, 25°C
0.0249
acetyl-Leu-Arg methyl ester
-
pH 9.0, 25°C
0.182
acetyl-Met-Arg methyl ester
-
pH 9.0, 25°C
0.14
acetyl-Phe-Arg ethyl ester
-
-
0.0244 - 0.0311
acetyl-Phe-Arg methyl ester
0.27
acetyl-Phe-Arg-Ala
-
pH 8.0, 25°C
-
0.15
acetyl-Phe-Arg-p-nitroanilide
-
pH 8.0, 25°C
0.21
acetyl-Phe-Arg-Ser-NH2
-
pH 9.0, 25°C
0.31
acetyl-Phe-Arg-Ser-Val-Gln
-
pH 9.0, 25°C
0.04
acetyl-Phe-Arg-Ser-Val-NH2
-
pH 9.0, 25°C
0.153
acetyl-Pro-Arg methyl ester
-
pH 9.0, 25°C
0.089
acetyl-Pro-Phe-Arg methyl ester
-
pH 8.0, 25°C
0.21
acetyl-Pro-Phe-Arg-Ala
-
pH 8.0, 25°C
0.087
acetyl-Pro-Phe-Arg-p-nitroanilide
-
pH 8.0, 25°C
0.027
acetyl-Trp-Arg methyl ester
-
pH 9.0, 25°C
0.132
acetyl-Tyr-Arg methyl ester
-
pH 9.0, 25°C
0.283
acetyl-Val-Arg methyl ester
-
pH 9.0, 25°C
0.02
Ala-Arg-Arg-4-methylcoumarin 7-amide
-
-
0.02
Ala-Arg-Arg-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
0.45
benzoyl-Pro-Phe-Arg-p-nitroanilide
-
pH 8.0, 37°C
0.243
benzyloxycarbonyl-Arg methyl ester
-
pH 8.0, 25°C
1.25
benzyloxycarbonyl-Arg-Ala-NH2
-
pH 8.0, 25°C
0.327
benzyloxycarbonyl-Arg-p-nitroanilide
-
pH 8.0, 25°C
0.209
benzyloxycarbonyl-Pro-Gly-Arg methyl ester
-
-
0.0114
benzyloxycarbonyl-Pro-Phe-Arg methyl ester
-
pH 9.0, 25°C
61.1
citrated bovine plasma
-
pH 7.8, 37°C
-
50.8
citrated dog plasma
-
pH 7.8, 37°C
-
0.00018 - 0.0031
D-Pro-Phe-Arg-4-methylcoumarin-7-amide
0.001 - 0.07
D-Pro-Phe-Phe-4-methylcoumarin-7-amide
0.0183 - 28.4
D-Val-Leu-Arg-p-nitroanilide
0.868
D-Val-Leu-Lys-4-nitroanilide
-
pH 8.5, 37°C
0.528
D-Val-Leu-Lys-p-nitroanilide
-
pH 8.0, 37°C
0.12 - 58.8
DL-Val-Leu-Arg-p-nitroanilide
0.064
FSPFRSVQ
-
pH 9.0, 25°C
0.27
Gln-Ala-Arg-7-amido-4-methylcoumarin
37°C, pH 7.5
1.18
Gly-Pro-Arg-7-amido-4-methylcoumarin
37°C, pH 7.5
17.6
human high molecular weight kininogen
-
pH 7.8, 37°C
-
12.7
human low molecular weight kininogen
-
pH 7.8, 37°C
-
0.071
Leu-Leu-Arg-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
0.383
N-alpha-acetyl-Arg-p-nitroanilide
-
pH 8.5, 37°C
50
N-alpha-acetyl-Tyr ethyl ester
-
pH 8.0, 40°C
0.104
N-alpha-benzoyl-L-Arg ethyl ester
-
pH 8.0, 40°C
0.125
N-alpha-benzoyl-L-Arg methyl ester
-
pH 8.0, 40°C
0.08 - 0.333
N-alpha-benzoyl-L-arginine ethyl ester
12.3
N-alpha-benzoyl-L-citrulline methyl ester
-
pH 8.0, 40°C
2
N-alpha-benzoyl-L-Lys methyl ester
-
pH 8.0, 40°C
2.44
N-alpha-benzoyl-L-Orn methyl ester
-
pH 8.0, 40°C
0.031
N-alpha-toluenesulfonyl-L-Arg methyl ester
-
pH 8.0, 40°C
0.022 - 0.117
N-alpha-tosyl-L-arginine methyl ester
0.00027
o-aminobenzoyl-AIKFFIRE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.00013
o-aminobenzoyl-AIKFFQRE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.0018
o-aminobenzoyl-AIKFFSAE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.00021
o-aminobenzoyl-AIKFFSKE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.0013
o-aminobenzoyl-AIKFFSPE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.00036
o-aminobenzoyl-AIKFFSRE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.00094
o-aminobenzoyl-AIKFFSSE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.00023
o-aminobenzoyl-AIKFFTRE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.0002 - 0.0006
o-aminobenzoyl-FRSSR-N-(2,4-dinitrophenyl)ethylene diamine
0.0009 - 0.0073
o-aminobenzoyl-FRSVQ-N-(2,4-dinitrophenyl)ethylene diamine
0.0007
o-aminobenzoyl-GFSPF-4-(aminocyclohexyl)alanine-SSRPQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.0038
o-aminobenzoyl-GFSPF-4-(aminomethyl)-N-isopropylphenylalanine-SSRPQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.0003
o-aminobenzoyl-GFSPF-4-(aminomethyl)phenylalanine-SSRPQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.00064
o-aminobenzoyl-GFSPF-4-piperidinylalanine-SSRPQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.001
o-aminobenzoyl-GFSPF-Nim-(dimethyl)histidine-SSRPQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.00096 - 0.00147
o-aminobenzoyl-GFSPFRAPRVQ-ethylenediamine 2,4-dinitrophenol
0.0067 - 0.0104
o-aminobenzoyl-GFSPFRSSRIGEIKEEQ-N-(2,4-dinitrophenyl)ethylene diamine
0.0004 - 0.00076
o-aminobenzoyl-GFSPFRSSRQ-N-(2,4-dinitrophenyl)ethylene diamine
0.00035 - 0.0014
o-aminobenzoyl-GFSPFRSVQ-N-(2,4-dinitrophenyl)ethylene diamine
0.00041 - 0.00051
o-aminobenzoyl-GFSPFRSVQVMKYEGSQ-N-(2,4-dinitrophenyl)ethylene diamine
0.00017 - 0.00251
o-aminobenzoyl-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol
0.0023 - 0.0047
o-aminobenzoyl-LMKRP-N-(2,4-dinitrophenyl)ethylene diamine
0.0027
o-aminobenzoyl-LPRTMFIQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 8.0, 37°C
0.0007
o-aminobenzoyl-LPRTMQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 8.0, 37°C
0.003 - 0.00735
o-aminobenzoyl-MTEMARRPQ-ethylenediamine 2,4-dinitrophenol
0.00223 - 0.0024
o-aminobenzoyl-MTSVIRRPQ-ethylenediamine 2,4-dinitrophenol
0.0036
o-aminobenzoyl-Phe-4-(aminomethyl)phenylalanine-Ser-Arg-Gln-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.0002 - 0.00033
o-aminobenzoyl-Phe-Arg-Arg-ethylenediamine 2,4-dinitrophenol
0.00024 - 0.00077
o-aminobenzoyl-Phe-Arg-Lys-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol
0.0007
o-aminobenzoyl-Phe-Nim-(dimethyl)histidine-Ser-Arg-Gln-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.0039 - 0.0042
o-aminobenzoyl-QPLGMISLMKRP-N-(2,4-dinitrophenyl)ethylene diamine
0.0003 - 0.0455
o-aminobenzoyl-QPLGQTSLMKRP-N-(2,4-dinitrophenyl)ethylene diamine
0.00023
o-aminobenzoyl-VMIAALPRTMFIQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 8.0, 37°C
0.0005
o-aminobenzoyl-VMIAALPRTMQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 8.0, 37°C
0.057
PFRSVQ
-
pH 9.0, 25°C
2.2
Phe-Arg-Ser-Val-Gln
-
pH 9.0, 25°C
0.44
Phe-Ser-Arg-7-amido-4-methylcoumarin
37°C, pH 7.5
0.07 - 0.114
Pro-Phe-Arg-4-methylcoumarin 7-amide
0.53
Pro-Phe-Arg-7-amido-4-methylcoumarin
37°C, pH 7.5
0.04
Pro-Phe-Arg-Arg-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
0.066
RPPGFSPFRSVQ
-
pH 9.0, 25°C
0.516 - 0.842
succinyl-Val-Pro-Phe-thiobenzyl ester
0.103
tosyl-Gly-Pro-Arg-p-nitroanilide
-
pH 8.0, 37°C
0.28
Val-Pro-Arg-7-amido-4-methylcoumarin
37°C, pH 7.5
0.048
Val-Pro-Arg-Arg-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
0.067
Z-L-Phe-L-Arg-7-amido-4-methylcoumarin
-
pH 7.5, 25°C
additional information
additional information
-
0.00062
Abz-KLRSSQ-EDDnp
-
isoform KLK2, at pH 7.5 and 37°C
0.00065
Abz-KLRSSQ-EDDnp
-
isoform KLK1, at pH 7.5 and 37°C
0.6
acetyl-Ala-Arg methyl ester
-
pH 9.0, 25°C
1.14
acetyl-Ala-Arg methyl ester
-
pH 8.0, 25°C
0.0244
acetyl-Phe-Arg methyl ester
-
pH 9.0, 25°C
0.0311
acetyl-Phe-Arg methyl ester
-
pH 8.0, 25°C
0.00018
D-Pro-Phe-Arg-4-methylcoumarin-7-amide
-
37°C, pH 8.5
0.0015
D-Pro-Phe-Arg-4-methylcoumarin-7-amide
-
37°C, pH 8.5
0.0031
D-Pro-Phe-Arg-4-methylcoumarin-7-amide
-
37°C, pH 8.5
0.001
D-Pro-Phe-Phe-4-methylcoumarin-7-amide
-
37°C, pH 8.5
0.0027
D-Pro-Phe-Phe-4-methylcoumarin-7-amide
-
37°C, pH 8.5
0.07
D-Pro-Phe-Phe-4-methylcoumarin-7-amide
-
37°C, pH 8.5
0.0183
D-Val-Leu-Arg-p-nitroanilide
-
pH 8.5, 37°C
0.06
D-Val-Leu-Arg-p-nitroanilide
-
-
28.4
D-Val-Leu-Arg-p-nitroanilide
-
pH 7.8, 37°C
0.12
DL-Val-Leu-Arg-p-nitroanilide
-
recombinant enzyme from liver, pH 8.0, 22°C
0.14
DL-Val-Leu-Arg-p-nitroanilide
-
natural urinary enzyme, pH 8.0, 22°C
0.154
DL-Val-Leu-Arg-p-nitroanilide
-
recombinant enzyme from salivary gland, pH 8.0, 22°C
0.158
DL-Val-Leu-Arg-p-nitroanilide
-
recombinant enzyme from pancreas, pH 8.0, 22°C
1.83
DL-Val-Leu-Arg-p-nitroanilide
-
pH 8.0, 37°C
58.8
DL-Val-Leu-Arg-p-nitroanilide
-
natural urinary enzyme, pH 8.0, 22°C
0.08
N-alpha-benzoyl-L-arginine ethyl ester
-
Cbeta-kallikrein, pH 8.0, 25°C
0.109
N-alpha-benzoyl-L-arginine ethyl ester
-
Abeta-kallikrein, pH 8.0, 25°C
0.234
N-alpha-benzoyl-L-arginine ethyl ester
-
alpha-kallikrein, pH 8.0, 25°C
0.333
N-alpha-benzoyl-L-arginine ethyl ester
-
Tbeta-kallikrein, pH 8.0, 25°C
0.022
N-alpha-tosyl-L-arginine methyl ester
-
Cbeta-kallikrein, pH 8.0, 25°C
0.039
N-alpha-tosyl-L-arginine methyl ester
-
alpha-kallikrein, pH 8.0, 25°C
0.048
N-alpha-tosyl-L-arginine methyl ester
-
Abeta-kallikrein, pH 8.0, 25°C
0.117
N-alpha-tosyl-L-arginine methyl ester
-
Tbeta-kallikrein, pH 8.0, 25°C
0.0002
o-aminobenzoyl-FRSSR-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 30°C
0.0006
o-aminobenzoyl-FRSSR-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 30°C
0.0009
o-aminobenzoyl-FRSVQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 30°C
0.0073
o-aminobenzoyl-FRSVQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 30°C
0.00096
o-aminobenzoyl-GFSPFRAPRVQ-ethylenediamine 2,4-dinitrophenol
-
-
0.00147
o-aminobenzoyl-GFSPFRAPRVQ-ethylenediamine 2,4-dinitrophenol
-
-
0.0067
o-aminobenzoyl-GFSPFRSSRIGEIKEEQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 30°C
0.0104
o-aminobenzoyl-GFSPFRSSRIGEIKEEQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 30°C
0.0004
o-aminobenzoyl-GFSPFRSSRQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 30°C
0.00076
o-aminobenzoyl-GFSPFRSSRQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 30°C
0.00035
o-aminobenzoyl-GFSPFRSVQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 30°C
0.0014
o-aminobenzoyl-GFSPFRSVQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 30°C
0.00041
o-aminobenzoyl-GFSPFRSVQVMKYEGSQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 30°C
0.00051
o-aminobenzoyl-GFSPFRSVQVMKYEGSQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 30°C
0.00017
o-aminobenzoyl-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol
-
-
0.0021
o-aminobenzoyl-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol
-
-
0.00251
o-aminobenzoyl-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol
-
-
0.0023
o-aminobenzoyl-LMKRP-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 30°C
0.0047
o-aminobenzoyl-LMKRP-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 30°C
0.003
o-aminobenzoyl-MTEMARRPQ-ethylenediamine 2,4-dinitrophenol
-
-
0.00616
o-aminobenzoyl-MTEMARRPQ-ethylenediamine 2,4-dinitrophenol
-
-
0.00735
o-aminobenzoyl-MTEMARRPQ-ethylenediamine 2,4-dinitrophenol
-
-
0.00223
o-aminobenzoyl-MTSVIRRPQ-ethylenediamine 2,4-dinitrophenol
-
-
0.0024
o-aminobenzoyl-MTSVIRRPQ-ethylenediamine 2,4-dinitrophenol
-
-
0.0002
o-aminobenzoyl-Phe-Arg-Arg-ethylenediamine 2,4-dinitrophenol
-
-
0.00033
o-aminobenzoyl-Phe-Arg-Arg-ethylenediamine 2,4-dinitrophenol
-
-
0.00024
o-aminobenzoyl-Phe-Arg-Lys-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol
-
-
0.00077
o-aminobenzoyl-Phe-Arg-Lys-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol
-
-
0.0039
o-aminobenzoyl-QPLGMISLMKRP-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 30°C
0.0042
o-aminobenzoyl-QPLGMISLMKRP-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 30°C
0.0003
o-aminobenzoyl-QPLGQTSLMKRP-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 30°C
0.0455
o-aminobenzoyl-QPLGQTSLMKRP-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 30°C
0.07
Pro-Phe-Arg-4-methylcoumarin 7-amide
-
pH 9.0, 37°C
0.084
Pro-Phe-Arg-4-methylcoumarin 7-amide
-
naturally occuring urinary enzyme, pH 8.0, 22°C
0.099
Pro-Phe-Arg-4-methylcoumarin 7-amide
-
recombinant enzyme from liver, pH 8.0, 22°C
0.112
Pro-Phe-Arg-4-methylcoumarin 7-amide
-
recombinant enzyme from pancreas, pH 8.0, 22°C
0.114
Pro-Phe-Arg-4-methylcoumarin 7-amide
-
recombinant enzyme from salivary gland, pH 8.0, 22°C
0.516
succinyl-Val-Pro-Phe-thiobenzyl ester
-
naturally occuring urinary enzyme, pH 8.0, 22°C
0.668
succinyl-Val-Pro-Phe-thiobenzyl ester
-
recombinant enzyme from liver, pH 8.0, 22°C
0.764
succinyl-Val-Pro-Phe-thiobenzyl ester
-
recombinant enzyme from salivary gland, pH 8.0, 22°C
0.842
succinyl-Val-Pro-Phe-thiobenzyl ester
-
recombinant enzyme from pancreas, pH 8.0, 22°C
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.1
Abz-ALFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.09
Abz-FLFSSKQ-EDDnp
-
at pH 7.5 and 37°C
1.6
Abz-FRSSR-Q-EDDnp
pH and temperature not specified in the publication
4.6
Abz-GFSPFRSLRI-Q-EDDnp
pH and temperature not specified in the publication
17.7
Abz-GFSPFRSSRI-Q-EDDnp
pH and temperature not specified in the publication
0.03
Abz-GLFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.1
Abz-HLFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.06
Abz-ILFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.02
Abz-KAFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.02
Abz-KFFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.04
Abz-KLFFSK-EDDnp
-
at pH 7.5 and 37°C
0.04
Abz-KLFRSK-EDDnp
-
at pH 7.5 and 37°C
0.43
Abz-KLFSAKQ-EDDnp
-
at pH 7.5 and 37°C
0.04
Abz-KLFSGKQ-EDDnp
-
at pH 7.5 and 37°C
0.09
Abz-KLFSIKQ-EDDnp
-
at pH 7.5 and 37°C
0.15
Abz-KLFSLKQ-EDDnp
-
at pH 7.5 and 37°C
0.04
Abz-KLFSNKQ-EDDnp
-
at pH 7.5 and 37°C
0.15
Abz-KLFSRKQ-EDDnp
-
at pH 7.5 and 37°C
0.05
Abz-KLFSSDQ-EDDnp
-
at pH 7.5 and 37°C
0.5
Abz-KLFSSEQ-EDDnp
-
at pH 7.5 and 37°C
0.09
Abz-KLFSSGQ-EDDnp
-
at pH 7.5 and 37°C
0.02
Abz-KLFSSIQ-EDDnp
-
at pH 7.5 and 37°C
0.1
Abz-KLFSSK-EDDnp
-
at pH 7.5 and 37°C
0.1
Abz-KLFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.08
Abz-KLFSSLQ-EDDnp
-
at pH 7.5 and 37°C
0.07
Abz-KLFSSNQ-EDDnp
-
at pH 7.5 and 37°C
0.14
Abz-KLFSSQQ-EDDnp
-
at pH 7.5 and 37°C
0.17
Abz-KLFSSRQ-EDDnp
-
at pH 7.5 and 37°C
0.43
Abz-KLFSSSQ-EDDnp
-
at pH 7.5 and 37°C
0.06
Abz-KLFSSVQ-EDDnp
-
at pH 7.5 and 37°C
0.35
Abz-KLFSVKQ-EDDnp
-
at pH 7.5 and 37°C
0.04
Abz-KLFTSK-EDDnp
-
at pH 7.5 and 37°C
0.04
Abz-KLFWSK-EDDnp
-
at pH 7.5 and 37°C
0.85
Abz-KLYSSK-EDDnp
-
at pH 7.5 and 37°C
0.02
Abz-KPFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.04
Abz-KVFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.02
Abz-KYFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.07
Abz-LLFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.02
Abz-MISLMKLP-Q-EDDnp
pH and temperature not specified in the publication
0.33
Abz-MISLMKRP-Q-EDDnp
pH and temperature not specified in the publication
0.28
Abz-NLFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.15
Abz-QLFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.13
Abz-RLFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.13
Abz-VLFSSKQ-EDDnp
-
at pH 7.5 and 37°C
1180
acetyl-2-aminohexanoic acid-Arg methyl ester
-
pH 9.0, 25°C
682
acetyl-Ala-Arg methyl ester
-
pH 9.0, 25°C
0.0542
acetyl-Ala-Arg-Ala
-
pH 8.0, 25°C
-
6.74
acetyl-Ala-Leu-Arg-p-nitroanilide
-
pH 8.5, 37°C
0.87
acetyl-Ala-Phe-Arg-Ala
-
pH 8.0, 25°C
1.71
acetyl-Ala-Phe-Arg-p-nitroanilide
-
pH 8.0, 25°C
0.72
acetyl-Ala-Thr-Arg-p-nitroanilide
-
pH 8.5, 37°C
0.02
acetyl-Arg-Ala-NH2
-
pH 8.0, 25°C
0.05
acetyl-Arg-p-nitroanilide
-
pH 8.0, 25°C
4.6
acetyl-D-Ala-Arg methyl ester
-
pH 9.0, 25°C
49
acetyl-D-Phe-Arg methyl ester
-
pH 9.0, 25°C
9.2
acetyl-Glu-Leu-Arg-p-nitroanilide
-
pH 8.5, 37°C
0.029
acetyl-Glu-Lys-Arg-p-nitroanilide
-
pH 8.5, 37°C
6.62
acetyl-Glu-Phe-Arg-p-nitroanilide
-
pH 8.5, 37°C
0.38
acetyl-Glu-Thr-Arg-p-nitroanilide
-
pH 8.5, 37°C
385
acetyl-Gly-Arg methyl ester
-
pH 9.0, 25°C
0.77
acetyl-Gly-Arg-Ser-Val-Gln
-
pH 9.0, 25°C
727
acetyl-Ile-Arg methyl ester
-
pH 9.0, 25°C
634
acetyl-Leu-Arg methyl ester
-
pH 9.0, 25°C
1380
acetyl-Met-Arg methyl ester
-
pH 9.0, 25°C
915
acetyl-Phe-Arg methyl ester
-
pH 9.0, 25°C
0.81
acetyl-Phe-Arg-Ala
-
pH 8.0, 25°C
-
1.69
acetyl-Phe-Arg-p-nitroanilide
-
pH 8.0, 25°C
2.1
acetyl-Phe-Arg-Ser-NH2
-
pH 9.0, 25°C
6.8
acetyl-Phe-Arg-Ser-Val-Gln
-
pH 9.0, 25°C
11.6
acetyl-Phe-Arg-Ser-Val-NH2
-
pH 9.0, 25°C
806
acetyl-Pro-Arg methyl ester
-
pH 9.0, 25°C
0.24
acetyl-Pro-Phe-Arg-Ala
-
pH 8.0, 25°C
0.78
acetyl-Pro-Phe-Arg-p-nitroanilide
-
pH 8.0, 25°C
438
acetyl-Trp-Arg methyl ester
-
pH 9.0, 25°C
680
acetyl-Tyr-Arg methyl ester
-
pH 9.0, 25°C
964
acetyl-Val-Arg methyl ester
-
pH 9.0, 25°C
0.12
Ala-Arg-Arg-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
0.113
benzyloxycarbonyl-Arg-Ala-NH2
-
pH 8.0, 25°C
0.014
benzyloxycarbonyl-Arg-p-nitroanilide
-
pH 8.0, 25°C
259
benzyloxycarbonyl-Pro-Gly-Arg methyl ester
-
pH 9.0, 25°C
537
benzyloxycarbonyl-Pro-Phe-Arg methyl ester
-
pH 9.0, 25°C
3.18 - 95.3
D-Pro-Phe-Arg-4-methylcoumarin-7-amide
0.05 - 12.5
D-Pro-Phe-Phe-4-methylcoumarin-7-amide
6.6
D-Val-Leu-Arg-p-nitroanilide
-
pH 8.5, 37°C
4.1
D-Val-Leu-Lys-4-nitroanilide
-
pH 8.5, 37°C
0.8 - 1.16
DL-Val-Leu-Arg-p-nitroanilide
6.4
FSPFRSVQ
-
pH 9.0, 25°C
0.0038
Gln-Ala-Arg-7-amido-4-methylcoumarin
37°C, pH 7.5
0.0035
Gly-Pro-Arg-7-amido-4-methylcoumarin
37°C, pH 7.5
0.04
Leu-Leu-Arg-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
0.154
N-alpha-acetyl-Arg-p-nitroanilide
-
pH 8.5, 37°C
11.2
N-alpha-acetyl-Tyr ethyl ester
-
pH 8.0, 25°C
123
N-alpha-benzoyl-L-Arg ethyl ester
-
pH 8.0, 25°C
154
N-alpha-benzoyl-L-Arg methyl ester
-
pH 8.0, 25°C
53.8 - 100
N-alpha-benzoyl-L-arginine ethyl ester
86.4
N-alpha-benzoyl-L-citrulline methyl ester
-
pH 8.0, 25°C
15.5
N-alpha-benzoyl-L-Lys methyl ester
-
pH 8.0, 25°C
1.8
N-alpha-benzoyl-L-Orn methyl ester
-
pH 8.0, 25°C
2.7
N-alpha-toluenesulfonyl-L-Arg methyl ester
-
pH 8.0, 25°C
2.35 - 9.38
N-alpha-tosyl-L-arginine methyl ester
0.05
o-aminobenzoyl-AIKFFIRE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.02
o-aminobenzoyl-AIKFFQRE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.54
o-aminobenzoyl-AIKFFSAE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.21
o-aminobenzoyl-AIKFFSKE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.05
o-aminobenzoyl-AIKFFSPE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
3.33
o-aminobenzoyl-AIKFFSRE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.3
o-aminobenzoyl-AIKFFSSE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.04
o-aminobenzoyl-AIKFFTRE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
1.4 - 7
o-aminobenzoyl-FRSSR-N-(2,4-dinitrophenyl)ethylene diamine
0.9 - 1.6
o-aminobenzoyl-FRSVQ-N-(2,4-dinitrophenyl)ethylene diamine
0.51
o-aminobenzoyl-GFSPF-4-(aminocyclohexyl)alanine-SSRPQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.81
o-aminobenzoyl-GFSPF-4-(aminomethyl)-N-isopropylphenylalanine-SSRPQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
1.8
o-aminobenzoyl-GFSPF-4-(aminomethyl)phenylalanine-SSRPQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.61
o-aminobenzoyl-GFSPF-4-piperidinylalanine-SSRPQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
2.1
o-aminobenzoyl-GFSPF-Nim-(dimethyl)histidine-SSRPQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
6.6 - 12
o-aminobenzoyl-GFSPFRAPRVQ-ethylenediamine 2,4-dinitrophenol
3 - 3.1
o-aminobenzoyl-GFSPFRSSRIGEIKEEQ-N-(2,4-dinitrophenyl)ethylene diamine
1 - 7.5
o-aminobenzoyl-GFSPFRSSRQ-N-(2,4-dinitrophenyl)ethylene diamine
0.94 - 4
o-aminobenzoyl-GFSPFRSVQ-N-(2,4-dinitrophenyl)ethylene diamine
1.5 - 40.1
o-aminobenzoyl-GFSPFRSVQVMKYEGSQ-N-(2,4-dinitrophenyl)ethylene diamine
3.1 - 14.7
o-aminobenzoyl-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol
0.04 - 0.076
o-aminobenzoyl-LMKRP-N-(2,4-dinitrophenyl)ethylene diamine
0.032
o-aminobenzoyl-LPRTMFIQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 8.0, 37°C
0.014
o-aminobenzoyl-LPRTMQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 8.0, 37°C
0.73 - 1.49
o-aminobenzoyl-MTEMARRPQ-ethylenediamine 2,4-dinitrophenol
3.27 - 5.86
o-aminobenzoyl-MTSVIRRPQ-ethylenediamine 2,4-dinitrophenol
1
o-aminobenzoyl-Phe-4-(aminomethyl)phenylalanine-Ser-Arg-Gln-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
12.7 - 18.7
o-aminobenzoyl-Phe-Arg-Arg-ethylenediamine 2,4-dinitrophenol
18.4 - 21.8
o-aminobenzoyl-Phe-Arg-Lys-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol
1.2
o-aminobenzoyl-Phe-Nim-(dimethyl)histidine-Ser-Arg-Gln-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.4 - 7.1
o-aminobenzoyl-QPLGMISLMKRP-N-(2,4-dinitrophenyl)ethylene diamine
0.6 - 1.1
o-aminobenzoyl-QPLGQTSLMKRP-N-(2,4-dinitrophenyl)ethylene diamine
0.0005
o-aminobenzoyl-VMIAALPRTMFIQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 8.0, 37°C
0.004
o-aminobenzoyl-VMIAALPRTMQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 8.0, 37°C
5.7
PFRSVQ
-
pH 9.0, 25°C
2.8
Phe-Arg-Ser-Val-Gln
-
pH 9.0, 25°C
0.0065
Phe-Ser-Arg-7-amido-4-methylcoumarin
37°C, pH 7.5
5.3 - 12.5
Pro-Phe-Arg-4-methylcoumarin 7-amide
0.031
Pro-Phe-Arg-7-amido-4-methylcoumarin
37°C, pH 7.5
0.917
Pro-Phe-Arg-Arg-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
5.7
RPPGFSPFRSVQ
-
pH 9.0, 25°C
2 - 29
succinyl-Val-Pro-Phe-thiobenzyl ester
0.0075
Val-Pro-Arg-7-amido-4-methylcoumarin
37°C, pH 7.5
0.0267
Val-Pro-Arg-Arg-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
additional information
additional information
-
3.18
D-Pro-Phe-Arg-4-methylcoumarin-7-amide
-
37°C, pH 8.5
3.2
D-Pro-Phe-Arg-4-methylcoumarin-7-amide
-
37°C, pH 8.5
3.6
D-Pro-Phe-Arg-4-methylcoumarin-7-amide
-
37°C, pH 8.5
95.3
D-Pro-Phe-Arg-4-methylcoumarin-7-amide
-
37°C, pH 8.5
0.05
D-Pro-Phe-Phe-4-methylcoumarin-7-amide
-
37°C, pH 8.5
0.085
D-Pro-Phe-Phe-4-methylcoumarin-7-amide
-
37°C, pH 8.5
12.5
D-Pro-Phe-Phe-4-methylcoumarin-7-amide
-
37°C, pH 8.5
0.8
DL-Val-Leu-Arg-p-nitroanilide
-
recombinant enzyme from liver, pH 8.0, 22°C
1.07
DL-Val-Leu-Arg-p-nitroanilide
-
recombinant salivary enzyme, pH 8.0, 22°C
1.16
DL-Val-Leu-Arg-p-nitroanilide
-
recombinant pancreatic enzyme, pH 8.0, 22°C
53.8
N-alpha-benzoyl-L-arginine ethyl ester
-
Tbeta-kallikrein, pH 8.0, 25°C
62.5
N-alpha-benzoyl-L-arginine ethyl ester
-
alpha-kallikrein, pH 8.0, 25°C
81.6
N-alpha-benzoyl-L-arginine ethyl ester
-
Abeta-kallikrein, pH 8.0, 25°C
100
N-alpha-benzoyl-L-arginine ethyl ester
-
Cbeta-kallikrein, pH 8.0, 25°C
2.35
N-alpha-tosyl-L-arginine methyl ester
-
Cbeta-kallikrein, pH 8.0, 25°C
2.75
N-alpha-tosyl-L-arginine methyl ester
-
Abeta-kallikrein, pH 8.0, 25°C
3.13
N-alpha-tosyl-L-arginine methyl ester
-
alpha-kallikrein, pH 8.0, 25°C
9.38
N-alpha-tosyl-L-arginine methyl ester
-
Tbeta-kallikrein, pH 8.0, 25°C
1.4
o-aminobenzoyl-FRSSR-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 30°C
7
o-aminobenzoyl-FRSSR-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 30°C
0.9
o-aminobenzoyl-FRSVQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 30°C
1.6
o-aminobenzoyl-FRSVQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 30°C
6.6
o-aminobenzoyl-GFSPFRAPRVQ-ethylenediamine 2,4-dinitrophenol
-
-
12
o-aminobenzoyl-GFSPFRAPRVQ-ethylenediamine 2,4-dinitrophenol
-
-
3
o-aminobenzoyl-GFSPFRSSRIGEIKEEQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 30°C
3.1
o-aminobenzoyl-GFSPFRSSRIGEIKEEQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 30°C
1
o-aminobenzoyl-GFSPFRSSRQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 30°C
7.5
o-aminobenzoyl-GFSPFRSSRQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 30°C
0.94
o-aminobenzoyl-GFSPFRSVQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 30°C
4
o-aminobenzoyl-GFSPFRSVQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 30°C
1.5
o-aminobenzoyl-GFSPFRSVQVMKYEGSQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 30°C
40.1
o-aminobenzoyl-GFSPFRSVQVMKYEGSQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 30°C
3.1
o-aminobenzoyl-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol
-
-
7
o-aminobenzoyl-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol
-
-
14.7
o-aminobenzoyl-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol
-
-
0.04
o-aminobenzoyl-LMKRP-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 30°C
0.076
o-aminobenzoyl-LMKRP-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 30°C
0.73
o-aminobenzoyl-MTEMARRPQ-ethylenediamine 2,4-dinitrophenol
-
-
0.8
o-aminobenzoyl-MTEMARRPQ-ethylenediamine 2,4-dinitrophenol
-
-
1.49
o-aminobenzoyl-MTEMARRPQ-ethylenediamine 2,4-dinitrophenol
-
-
3.27
o-aminobenzoyl-MTSVIRRPQ-ethylenediamine 2,4-dinitrophenol
-
-
5.86
o-aminobenzoyl-MTSVIRRPQ-ethylenediamine 2,4-dinitrophenol
-
-
12.7
o-aminobenzoyl-Phe-Arg-Arg-ethylenediamine 2,4-dinitrophenol
-
-
18.7
o-aminobenzoyl-Phe-Arg-Arg-ethylenediamine 2,4-dinitrophenol
-
-
18.4
o-aminobenzoyl-Phe-Arg-Lys-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol
-
-
21.8
o-aminobenzoyl-Phe-Arg-Lys-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol
-
-
0.4
o-aminobenzoyl-QPLGMISLMKRP-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 30°C
7.1
o-aminobenzoyl-QPLGMISLMKRP-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 30°C
0.6
o-aminobenzoyl-QPLGQTSLMKRP-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 30°C
1.1
o-aminobenzoyl-QPLGQTSLMKRP-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 30°C
5.3
Pro-Phe-Arg-4-methylcoumarin 7-amide
-
recombinant enzyme from liver, pH 8.0, 22°C
6.1
Pro-Phe-Arg-4-methylcoumarin 7-amide
-
naturally occuring urinary enzyme, pH 8.0, 22°C
7.3
Pro-Phe-Arg-4-methylcoumarin 7-amide
-
recombinant salivary enzyme, pH 8.0, 22°C
7.4
Pro-Phe-Arg-4-methylcoumarin 7-amide
-
recombinant pancreatic enzyme, pH 8.0, 22°C
12.5
Pro-Phe-Arg-4-methylcoumarin 7-amide
-
pH 9.0, 37°C
2
succinyl-Val-Pro-Phe-thiobenzyl ester
-
recombinant enzyme from liver and naturally occuring urinary enzyme, pH 8.0, 22°C
27
succinyl-Val-Pro-Phe-thiobenzyl ester
-
recombinant pancreatic enzyme, pH 8.0, 22°C
29
succinyl-Val-Pro-Phe-thiobenzyl ester
-
recombinant salivary enzyme, pH 8.0, 22°C
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
o-aminobenzoyl-MTSVIRRPQ-ethylenediamine 2,4-dinitrophenol
-
-
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