Sequence of CPT2_RAT

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
carnitine O-palmitoyltransferase
P18886
Rattus norvegicus
658
74110
Reaction
palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MMPRLLFRAW PRCPSLVLGA PSRPLSAVSG PDDYLQHSIV PTMHYQDSLP RLPIPKLEDT
 60 MKRYLNAQKP LLDDSQFRRT EALCKNFETG VGKELHAHLL AQDKQNKHTS YISGPWFDMY
120 LTARDSIVLN FNPFMAFNPD PKSEYNDQLT RATNLTVSAV RFLKTLQAGL LEPEVFHLNP
180 SKSDTDAFKR LIRFVPPSLS WYGAYLVNAY PLDMSQYFRL FNSTRIPRPN RDELFTDTKA
240 RHLLVLRKGH FYVFDVLDQD GNIVNPLEIQ AHLKYILSDS SPVPEFPVAY LTSENRDVWA
300 ELRQKLIFDG NEETLKKVDS AVFCLCLDDF PMKDLIHLSH TMLHGDGTNR WFDKSFNLIV
360 AEDGTAAVHF EHSWGDGVAV LRFFNEVFRD STQTPAITPQ SQPAATNSSA SVETLSFNLS
420 GALKAGITAA KEKFDTTVKT LSIDSIQFQR GGKEFLKKKQ LSPDAVAQLA FQMAFLRQYG
480 QTVATYESCS TAAFKHGRTE TIRPASIFTK RCSEAFVRDP SKHSVGELQH MMAECSKYHG
540 QLTKEAAMGQ GFDRHLYALR YLATARGLNL PELYLDPAYQ QMNHNILSTS TLNSPAVSLG
600 GFAPVVPDGF GIAYAVHDDW IGCNVSSYSG RNAREFLHCV QKCLEDIFDA LEGKAIKT
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
18982
Woeltje K.F.,Esser V.,Weis B.C.,Sen A.,Cox W.F.,McPhaul M.J.,Slaughter C.A.,Foster D.W.,McGarry J.D.
Cloning, sequencing, and expression of a cDNA encoding rat liver mitochondrial carnitine palmitoyltransferase II.
J. Biol. Chem.
265
10720-10725
1990
18983
de Vries Y.,Arvidson D.N.,Waterham H.R.,Cregg J.M.,Woldegiorgis G.
Functional characterization of mitochondrial carnitine palmitoyltransferases I and II expressed in the yeast Pichia pastoris.
Biochemistry
36
5285-5292
1997
18984
Brown N.F.,Esser V.,Gonzalez A.D.,Evans C.T.,Slaughter C.A.,Foster D.W.,McGarry J.D.
Mitochondrial import and processing of rat liver carnitine palmitoyltransferase II defines the amino terminus of the mature protein. Possibility of differential modification of the rat and human isoforms.
J. Biol. Chem.
266
15446-15449
1991
18985
Hsiao Y.-S.,Jogl G.,Esser V.,Tong L.
Crystal structure of rat carnitine palmitoyltransferase II (CPT-II).
Biochem. Biophys. Res. Commun.
346
974-980
2006
18986
Rufer A.C.,Thoma R.,Benz J.,Stihle M.,Gsell B.,De Roo E.,Banner D.W.,Mueller F.,Chomienne O.,Hennig M.
The crystal structure of carnitine palmitoyltransferase 2 and implications for diabetes treatment.
Structure
14
713-723
2006
18987
Rufer A.C.,Lomize A.,Benz J.,Chomienne O.,Thoma R.,Hennig M.
Carnitine palmitoyltransferase 2: analysis of membrane association and complex structure with a substrate analog.
FEBS Lett.
581
3247-3252
2007