Sequence of INSR_CAEEL
EC Number:2.7.10.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Other sequences found for EC No. 2.7.10.1
General information:
Sequence
0 MTRMNIVRCR RRHKILENLE EENLGPSCSS TTSTTAATEA LGTTTEDMRL KQQRSSSRAT
60 EHDIVDGNHH DDEHITMRRL RLVKNSRTRR RTTPDSSMDC YEENPPSQKT SINYSWISKK
120 SSMTSLMLLL LFAFVQPCAS IVEKRCGPID IRNRPWDIKP QWSKLGDPNE KDLAGQRMVN
180 CTVVEGSLTI SFVLKHKTKA QEEMHRSLQP RYSQDEFITF PHLREITGTL LVFETEGLVD
240 LRKIFPNLRV IGGRSLIQHY ALIIYRNPDL EIGLDKLSVI RNGGVRIIDN RKLCYTKTID
300 WKHLITSSIN DVVVDNAAEY AVTETGLMCP RGACEEDKGE SKCHYLEEKN QEQGVERVQS
360 CWSNTTCQKS CAYDRLLPTK EIGPGCDANG DRCHDQCVGG CERVNDATAC HACKNVYHKG
420 KCIEKCDAHL YLLLQRRCVT REQCLQLNPV LSNKTVPIKA TAGLCSDKCP DGYQINPDDH
480 RECRKCVGKC EIVCEINHVI DTFPKAQAIR LCNIIDGNLT IEIRGKQDSG MASELKDIFA
540 NIHTITGYLL VRQSSPFISL NMFRNLRRIE AKSLFRNLYA ITVFENPNLK KLFDSTTDLT
600 LDRGTVSIAN NKMLCFKYIK QLMSKLNIPL DPIDQSEGTN GEKAICEDMA INVSITAVNA
660 DSVFFSWPSF NITDIDQRKF LGYELFFKEV PRIDENMTIE EDRSACVDSW QSVFKQYYET
720 SNGEPTPDIF MDIGPRERIR PNTLYAYYVA TQMVLHAGAK NGVSKIGFVR TSYYTPDPPT
780 LALAQVDSDA IHITWEAPLQ PNGDLTHYTI MWRENEVSPY EEAEKFCTDA STPANRQHTK
840 DPKETIVADK PVDIPSSRTV APTLLTMMGH EDQQKTCAAT PGCCSCSAIE ESSEQNKKKR
900 PDPMSAIESS AFENKLLDEV LMPRDTMRVR RSIEDANRVS EELEKAENLG KAPKTLGGKK
960 PLIHISKKKP SSSSTTSTPA PTIASMYALT RKPTTVPGTR IRLYEIYEPL PGSWAINVSA
1020 LALDNSYVIR NLKHYTLYAI SLSACQNMTV PGASCSISHR AGALKRTKHI TDIDKVLNET
1080 IEWRFMNNSQ QVNVTWDPPT EVNGGIFGYV VKLKSKVDGS IVMTRCVGAK RGYSTRNQGV
1140 LFQNLADGRY FVSVTATSVH GAGPEAESSD PIVVMTPGFF TVEIILGMLL VFLILMSIAG
1200 CIIYYYIQVR YGKKVKALSD FMQLNPEYCV DNKYNADDWE LRQDDVVLGQ QCGEGSFGKV
1260 YLGTGNNVVS LMGDRFGPCA IKINVDDPAS TENLNYLMEA NIMKNFKTNF IVKLYGVIST
1320 VQPAMVVMEM MDLGNLRDYL RSKREDEVFN ETDCNFFDII PRDKFHEWAA QICDGMAYLE
1380 SLKFCHRDLA ARNCMINRDE TVKIGDFGMA RDLFYHDYYK PSGKRMMPVR WMSPESLKDG
1440 KFDSKSDVWS FGVVLYEMVT LGAQPYIGLS NDEVLNYIGM ARKVIKKPEC CENYWYKVMK
1500 MCWRYSPRDR PTFLQLVHLL AAEASPEFRD LSFVLTDNQM ILDDSEALDL DDIDDTDMND
1560 QVVEVAPDVE NVEVQSDSER RNTDSIPLKQ FKTIPPINAT TSHSTISIDE TPMKAKQREG
1620 SLDEEYALMN HSGGPSDAEV RTYAGDGDYV ERDVRENDVP TRRNTGASTS SYTGGGPYCL
1680 TNRGGSNERG AGFGEAVRLT DGVGSGHLND DDYVEKEISS MDTRRSTGAS SSSYGVPQTN
1740 WSGNRGATYY TSKAQQAATA AAAAAAALQQ QQNGGRGDRL TQLPGTGHLQ STRGGQDGDY
1800 IETEPKNYRN NGSPSRNGNS RDIFNGRSAF GENEHLIEDN EHHPLV
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
48027
Kimura K.D.,Tissenbaum H.A.,Liu Y.,Ruvkun G.
daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans.
Science
277
942-946
1997
48028
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science
282
2012-2018
1998
48029
Apfeld J.,Kenyon C.
Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span.
Cell
95
199-210
1998
48030
Pierce S.B.,Costa M.,Wisotzkey R.,Devadhar S.,Homburger S.A.,Buchman A.R.,Ferguson K.C.,Heller J.,Platt D.M.,Pasquinelli A.A.,Liu L.X.,Doberstein S.K.,Ruvkun G.
Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family.
Genes Dev.
15
672-686
2001
48031
Yu H.,Larsen P.L.
DAF-16-dependent and independent expression targets of DAF-2 insulin receptor-like pathway in Caenorhabditis elegans include FKBPs.
J. Mol. Biol.
314
1017-1028
2001
48032
Tomioka M.,Adachi T.,Suzuki H.,Kunitomo H.,Schafer W.R.,Iino Y.
The insulin/PI 3-kinase pathway regulates salt chemotaxis learning in Caenorhabditis elegans.
Neuron
51
613-625
2006
48033
Kaji H.,Kamiie J.,Kawakami H.,Kido K.,Yamauchi Y.,Shinkawa T.,Taoka M.,Takahashi N.,Isobe T.
Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.
Mol. Cell. Proteomics
6
2100-2109
2007
48034
Evans E.A.,Chen W.C.,Tan M.-W.
The DAF-2 insulin-like signaling pathway independently regulates aging and immunity in C. elegans.
Aging Cell
7
879-893
2008
48035
Dixon S.J.,Alexander M.,Chan K.K.,Roy P.J.
Insulin-like signaling negatively regulates muscle arm extension through DAF-12 in Caenorhabditis elegans.
Dev. Biol.
318
153-161
2008
48036
Neumann-Haefelin E.,Qi W.,Finkbeiner E.,Walz G.,Baumeister R.,Hertweck M.
SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans.
Genes Dev.
22
2721-2735
2008
48037
Patel D.S.,Garza-Garcia A.,Nanji M.,McElwee J.J.,Ackerman D.,Driscoll P.C.,Gems D.
Clustering of genetically defined allele classes in the Caenorhabditis elegans DAF-2 insulin/IGF-1 receptor.
Genetics
178
931-946
2008
48038
Fierro-Gonzalez J.C.,Gonzalez-Barrios M.,Miranda-Vizuete A.,Swoboda P.
The thioredoxin TRX-1 regulates adult lifespan extension induced by dietary restriction in Caenorhabditis elegans.
Biochem. Biophys. Res. Commun.
406
478-482
2011
48039
Huang X.,Zhang H.,Zhang H.
The zinc-finger protein SEA-2 regulates larval developmental timing and adult lifespan in C. elegans.
Development
138
2059-2068
2011
48040
Robida-Stubbs S.,Glover-Cutter K.,Lamming D.W.,Mizunuma M.,Narasimhan S.D.,Neumann-Haefelin E.,Sabatini D.M.,Blackwell T.K.
TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.
Cell Metab.
15
713-724
2012
48041
Korta D.Z.,Tuck S.,Hubbard E.J.
S6K links cell fate, cell cycle and nutrient response in C. elegans germline stem/progenitor cells.
Development
139
859-870
2012
48042
Chen D.,Li P.W.,Goldstein B.A.,Cai W.,Thomas E.L.,Chen F.,Hubbard A.E.,Melov S.,Kapahi P.
Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans.
Cell Rep.
5
1600-1610
2013
48043
Ferguson A.A.,Roy S.,Kormanik K.N.,Kim Y.,Dumas K.J.,Ritov V.B.,Matern D.,Hu P.J.,Fisher A.L.
TATN-1 mutations reveal a novel role for tyrosine as a metabolic signal that influences developmental decisions and longevity in Caenorhabditis elegans.
PLoS Genet.
9
0-0
2013
48044
Liu J.,Visser-Grieve S.,Boudreau J.,Yeung B.,Lo S.,Chamberlain G.,Yu F.,Sun T.,Papanicolaou T.,Lam A.,Yang X.,Chin-Sang I.
Insulin activates the insulin receptor to downregulate the PTEN tumour suppressor.
Oncogene
33
3878-3885
2014
48045
Narbonne P.,Maddox P.S.,Labbe J.C.
DAF-18/PTEN locally antagonizes insulin signalling to couple germline stem cell proliferation to oocyte needs in C. elegans.
Development
142
4230-4241
2015
48046
Tiku V.,Jain C.,Raz Y.,Nakamura S.,Heestand B.,Liu W.,Spaeth M.,Suchiman H.E.D.,Mueller R.U.,Slagboom P.E.,Partridge L.,Antebi A.
Small nucleoli are a cellular hallmark of longevity.
Nat. Commun.
8
16083-16083
2016
48047
De Magalhaes Filho C.D.,Henriquez B.,Seah N.E.,Evans R.M.,Lapierre L.R.,Dillin A.
Visible light reduces C. elegans longevity.
Nat. Commun.
9
927-927
2018
