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EC Number	Protein Variants	Commentary	Reference
2.7.8.B11	more	Escherichia coli has three cardiolipin synthases. Cardiolipin synthase A encoded by clsA, cardiolipin synthase B encoded by clsB and cardiolipin synthase C, encoded by clsC. Deletion of all three genes (DELTAclsABC) results in a complete lack of cardiolipin. Restoration of nearwild-type levels of cardiolipin production in the stationary phase by expression of clsC in the triple mutant requires the coexpression from the same operon of the preceding gene ymdB. The mode of cardiolipin biosynthesis by the combined YmdB-ClsC follows neither the eukaryotic nor prokaryotic pathway but involves the transfer of a phosphatidyl moiety from PE to the terminal free hydroxyl of PG to form cardiolipin	728679

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Release 2023.1 (January 2023)