EC Number   |
Protein Variants |
Reference |
|---|
  1.3.3.15 | F187W |
the mutation inhibits the activation of the enzyme by VU0038882 |
-, 765676 |
| 1.3.3.15 | F227R |
the mutant exhibits slight decrease in catalysis compared to the wild type enzyme |
712895 |
| 1.3.3.15 | I176A |
the mutation leads to about 30fold decrease in catalytic efficiency compared to the wild type enzyme |
712895 |
| 1.3.3.15 | K71A |
the mutation leads to about 50fold decrease in catalytic efficiency compared to the wild type enzyme |
-, 712895 |
| 1.3.3.15 | M167F |
the mutation inhibits the activation of the enzyme by VU0038882 |
-, 765676 |
| 1.3.3.15 | N186F |
the mutant exhibits increased baseline activity relative to the wild type enzyme |
-, 765676 |
| 1.3.3.15 | N186Y |
the mutant exhibits increased baseline activity relative to the wild type enzyme |
-, 765676 |
| 1.3.3.15 | P64A |
the mutant exhibits a 14fold decrease in catalysis compared to the wild type enzyme |
712895 |
| 1.3.3.15 | T183K |
the mutation does not restrict enzyme function. The mutant does not respond to VU0038882 at concentrations up to 0.01 mM |
-, 765676 |
| 1.3.3.15 | Y366N |
the mutation leads to about 100fold decrease in catalytic efficiency compared to the wild type enzyme |
712895 |
