EC Number   |
Disease |
PubMed ID |
Title of Publication  |
Category |
Confidence Level |
|---|
   3.4.22.55 | Neoplasms |
22002103 |
5-Phenylselenyl- and 5-methylselenyl-methyl-2'-deoxyuridine induce oxidative stress, DNA damage, and caspase-2-dependent apoptosis in cancer cells. |
causal interaction
unassigned |
4
0 |
| 3.4.22.55 | Neoplasms |
29362422 |
A caspase-2-RFXANK interaction and its implication for MHC class II expression. |
causal interaction
therapeutic application
unassigned |
1
1
0 |
| 3.4.22.55 | Astrocytoma |
12761355 |
A key role for caspase-2 and caspase-3 in the apoptosis induced by 2-chloro-2'-deoxy-adenosine (cladribine) and 2-chloro-adenosine in human astrocytoma cells. |
ongoing research
therapeutic application
unassigned |
2
2
0 |
| 3.4.22.55 | Neoplasms |
24879153 |
A nonapoptotic role for CASP2/caspase 2: modulation of autophagy. |
causal interaction
therapeutic application
unassigned |
3
1
0 |
| 3.4.22.55 | Breast Neoplasms |
29321954 |
A role for caspase-2 in sphingosine kinase 1 proteolysis in response to doxorubicin in breast cancer cells - implications for the CHK1-suppressed pathway. |
ongoing research
therapeutic application
unassigned |
4
1
0 |
| 3.4.22.55 | Alzheimer Disease |
31362787 |
A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease. |
causal interaction
unassigned |
3
0 |
| 3.4.22.55 | Dementia |
31362787 |
A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease. |
causal interaction
unassigned |
3
0 |
| 3.4.22.55 | Frontotemporal Dementia |
31362787 |
A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease. |
causal interaction
unassigned |
3
0 |
| 3.4.22.55 | Lewy Body Disease |
31362787 |
A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease. |
causal interaction
unassigned |
3
0 |
| 3.4.22.55 | Huntington Disease |
31358058 |
A soluble truncated tau species related to cognitive dysfunction and caspase-2 is elevated in the brain of Huntington's disease patients. |
unassigned |
0 |
