EC Number |
Turnover Number Minimum [1/s] |
Turnover Number Maximum [1/s] |
Substrate |
Reference |
---|
3.4.17.11 | 2.9 |
- |
diallyl 4-[[2'-[N,N-bis(2''-chloroethyl)amino]phenyl]carbamoyloxymethyl]phenylcarbamoyl-L-glutamic acid |
- |
647250 |
3.4.17.11 | 5.5 |
- |
diallyl 4-[N-[4'-bis(2''-chloroethyl)aminophenyl]-N-methylcarbamoyloxymethyl]phenylcarbamoyl-L-glutamic acid |
- |
647250 |
3.4.17.11 | 24.83 |
- |
methotrexate |
pH 7.3, 37°C, wild-type enzyme |
752914 |
3.4.17.11 | 26.11 |
- |
methotrexate |
pH 7.3, 37°C, mutant enzyme I100T |
752914 |
3.4.17.11 | 26.93 |
- |
methotrexate |
pH 7.3, 37°C, mutant enzyme T329A |
752914 |
3.4.17.11 | 27.21 |
- |
methotrexate |
pH 7.3, 37°C, mutant enzyme G123S |
752914 |
3.4.17.11 | 220 |
- |
(4-[bis(2-iodoethyl)amino]-2,3,5-trifluorobenzoyl)-L-glutamic acid |
pH 7.3, 37 °C |
669785 |
3.4.17.11 | 583 |
- |
(2-chloroethyl)-(2-(methylsulfoyloxyethyl)amino)aminobenzyl-L-glutamic acid |
pH 7.3, 37 °C |
669785 |
3.4.17.11 | 732 |
- |
(4-[bis(2-chloroethyl)amino]-3,5-difluorobenzoyl)-L-glutamic acid |
pH 7.3, 37 °C |
669785 |
3.4.17.11 | 732 |
- |
[4-[bis(2-chloroethyl)amino]-3,5-difluorobenzoyl]-L-glutamic acid |
- |
700491 |