EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
3.4.22.62 | Ac-LEDH-4-nitroanilide + H2O |
- |
Larimichthys crocea |
Ac-LEDH + 4-nitroaniline |
- |
? |
3.4.22.62 | acetyl-Asp-Glu-Val-Asp-p-nitroanilide + H2O |
i.e. Ac-DEVD-pNA, caspase-9/-3 activation in differentiated cells can be prevented by protein kinase C (PKC) and the mitogen activated protein kinase (MEK) signaling pathways |
Homo sapiens |
acetyl-Asp-Glu-Val-Asp + p-nitroaniline |
- |
? |
3.4.22.62 | acetyl-DEVD-7-amido-4-methylcoumarin + H2O |
- |
Homo sapiens |
acetyl-DEVD + 7-amino-4-methylcoumarin |
- |
? |
3.4.22.62 | acetyl-DEVD-7-amido-4-trifluoromethylcoumarin + H2O |
activation of caspase-3 by caspase-9 indirectly measured by caspase-3 assay |
Rattus norvegicus |
acetyl-DEVD + 7-amino-4-trifluoromethylcoumarin |
- |
? |
3.4.22.62 | acetyl-DEVD-7-amido-4-trifluoromethylcoumarin + H2O |
apoptosome inhibitors analyzed, caspase-9 activity indirectly measured by caspase-3 assay |
Homo sapiens |
acetyl-DEVD + 7-amino-4-trifluoromethylcoumarin |
- |
? |
3.4.22.62 | acetyl-Ile-Glu-Thr-Asp-p-nitroanilide + H2O |
13% of the activity with acetyl-Leu-Glu-His-Asp-p-nitroanilide |
Cricetulus griseus |
acetyl-Ile-Glu-Thr-Asp + p-nitroaniline |
- |
? |
3.4.22.62 | acetyl-LEHD-7-amido-4-trifluoromethyl coumarin + H2O |
- |
Homo sapiens |
acetyl-LEHD + 7-amino-4-trifluoromethyl coumarin |
- |
? |
3.4.22.62 | acetyl-LEHD-7-amido-4-trifluoromethyl coumarin + H2O |
activity of caspase-9 determined after treatment of cells with 10 mg/ml recombinant Vibrio vulnificus cytolysin (rVVC) for 0.5, 1, 2, 3 and 4 h |
Homo sapiens |
acetyl-LEHD + 7-amino-4-trifluoromethyl coumarin |
- |
? |
3.4.22.62 | acetyl-LEHD-7-amido-4-trifluoromethylcoumarin + H2O |
- |
Homo sapiens |
acetyl-LEHD + 7-amino-4-trifluoromethylcoumarin |
- |
? |
3.4.22.62 | acetyl-LEHD-7-amido-4-trifluoromethylcoumarin + H2O |
i.e. Ac-Leu-Glu-His-Asp-MCA, fluorescence assay, 50 microg cell lysate incubated with 5 microl of 1 mM substrate |
Homo sapiens |
acetyl-LEHD + 7-amino-4-trifluoromethylcoumarin |
- |
? |