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Information on EC 3.4.22.62 - caspase-9

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.62 caspase-9
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Word Map
  • 3.4.22.62
  • caspase-3
  • parp
  • pro-apoptotic
  • anti-apoptotic
  • bcl-xl
  • tunel
  • annexin
  • apoptosis-related
  • caspase-dependent
  • apoptosis-inducing
  • apaf-1
  • extrinsic
  • polyadp-ribose
  • hoechst
  • iodide
  • nick
  • dutp
  • adp-ribose
  • sub-g1
  • cisplatin
  • z-vad-fmk
  • survivin
  • antiproliferative
  • deoxynucleotidyl
  • depolarization
  • mitochondria-dependent
  • trail
  • mitochondria-mediated
  • apoptogenic
  • cytochrome-c
  • ladder
  • medicine
  • factor-related
  • cdc25c
  • z-devd-fmk
  • tunel-positive
  • caspase-mediated
  • pharmacology
  • puma
  • procaspase-3
  • fas-mediated
  • v-fitc
  • bcl-2-associated
  • apoptosis-associated
  • trail-induced
  • c-flips
  • transferase-mediated
  • deltapsim
  • pan-caspase
  • anti-fas
  • fas-associated
  • executioner
The enzyme appears in viruses and cellular organisms
Reaction Schemes
strict requirement for an Asp residue at position P1 and with a marked preference for His at position P2. It has a preferred cleavage sequence of Leu-Gly-His-Asp-/-Xaa
Synonyms
caspase 9, casp9, casp-9, ice-lap6, casp9-gamma, apaf-3, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
strict requirement for an Asp residue at position P1 and with a marked preference for His at position P2. It has a preferred cleavage sequence of Leu-Gly-His-Asp-/-Xaa
show the reaction diagram
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