EC Number   |
Substrates |
Organism |
Products |
Reversibility  |
|---|
   2.1.1.244 | more |
alpha-N-terminal methylation of histone H2B protein in Drosophila melanogaster |
Drosophila melanogaster |
? |
- |
- |
| 2.1.1.244 | more |
human MTase-like protein 13 (METTL13) is a dual MTase for both N-terminal Gly1 and Lys55 of human eEF1A. To date, eEF1A is the only validated biological substrate for METTL13 |
Homo sapiens |
? |
- |
- |
| 2.1.1.244 | more |
PrmA preferentially methylates free ribosomal protein L11 over an assembled 50S ribosomal subunit |
Escherichia coli |
? |
- |
- |
| 2.1.1.244 | more |
protein N-terminal methyltransferase 1 (NTMT1/NRMT1) catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to protein alpha-N-terminal amines. It recognizes a specific motif X-P-K/R (X represents any amino acid other than D/E) |
Homo sapiens |
? |
- |
- |
| 2.1.1.244 | more |
substrate of NTMT1 are regulator of chromosome condensation 1 (RCC1), tumor suppressor retinoblastoma1 (RB1), oncoprotein SET (also known as I2PP2A, TAF1a), damaged DNA-binding protein2 (DDB2), poly(ADP-ribose) polymerase3 (PARP3), and centromere proteins A and B |
Homo sapiens |
? |
- |
- |
| 2.1.1.244 | more |
the methyltransferase N6AMT2 is responsible for Lys79 methylation of human eEF1A, but has been previously documented as a putative N(6)-adenine-specific DNA methyltransferase. It is renamed eEF1A-KMT1 |
Saccharomyces cerevisiae |
? |
- |
- |
| 2.1.1.244 | more |
the methyltransferase N6AMT2 is responsible for Lys79 methylation of human eEF1A, but has been previously documented as a putative N(6)-adenine-specific DNA methyltransferase. It is renamed eEF1A-KMT1 |
Homo sapiens |
? |
- |
- |
| 2.1.1.244 | more |
the substrate recognition motif is M-L/M/K-G/Q. PrmA preferentially methylates free ribosomal protein L11 over an assembled 50S ribosomal subunit |
Thermus thermophilus |
? |
- |
- |
| 2.1.1.244 | more |
YLR285W, also named elongation factor methyltransferase 7 (Efm7), is a dual MTase that installs methyl groups at both N-terminal Gly1 and Lys2 residues of yeast eEF1A protein. Lys2 is methylated only after trimethylation of Gly1. Yeast eEF1A starts with GKEKSHINV and is the only known substrate of Efm7, although there are 35 other yeast proteins with a G-K sequence at their N termini. But Efm7 is not able to methylate the synthetic decamer peptide GKEKSHINVV derived from the N-terminus of eEF1A |
Saccharomyces cerevisiae |
? |
- |
- |
| 2.1.1.244 | more |
analysis of methylation sites, method, detailed overview |
Saccharomyces cerevisiae |
? |
- |
- |
