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Information on EC 2.1.1.244 - protein N-terminal methyltransferase

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EC Tree
     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.244 protein N-terminal methyltransferase
IUBMB Comments
This enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys after the initiator L-methionine is cleaved. When the terminal amino acid is L-proline, the enzyme catalyses two successive methylations of its alpha-amino group. When the first amino acid is either L-alanine or L-serine, the enzyme catalyses three successive methylations. The Pro-Lys in positions 2-3 cannot be exchanged for other amino acids [1,2].
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
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3
+
N-terminal-(A,S)PK-[protein]
=
3
+
N-terminal-N,N,N-trimethyl-N-(A,S)PK-[protein]
2
+
N-terminal-PPK-[protein]
=
2
+
N-terminal-N,N-dimethyl-N-PPK-[protein]
Synonyms
nrmt1, n-terminal methyltransferase, ntmt1, n-terminal rcc1 methyltransferase, ybr261c/tae1, mettl11a, protein n-terminal methyltransferase 1, alpha-n-methyltransferase, ss alphan-methyltransferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 S-adenosyl-L-methionine + N-terminal-PPK-[protein] = 2 S-adenosyl-L-homocysteine + N-terminal-N,N-dimethyl-N-PPK-[protein]
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(2)
-
-
-
3 S-adenosyl-L-methionine + N-terminal-(A,S)PK-[protein] = 3 S-adenosyl-L-homocysteine + N-terminal-N,N,N-trimethyl-N-(A,S)PK-[protein]
show the reaction diagram
(1)
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-
-
S-adenosyl-L-methionine + N-terminal-(A,S)PK-[protein] = S-adenosyl-L-homocysteine + N-terminal-N-methyl-N-(A,S)PK-[protein]
show the reaction diagram
(1a)
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-
-
S-adenosyl-L-methionine + N-terminal-N,N-dimethyl-N-(A,S)PK-serine-[protein] = S-adenosyl-L-homocysteine + N-terminal-N,N,N-trimethyl-N-(A,S)PK-[protein]
show the reaction diagram
(1c)
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-
-
S-adenosyl-L-methionine + N-terminal-N-methyl-N-(A,S)PK-[protein] = S-adenosyl-L-homocysteine + N-terminal-N,N-dimethyl-N-(A,S)PK-[protein]
show the reaction diagram
(1b)
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-
-
S-adenosyl-L-methionine + N-terminal-N-methyl-N-PPK-[protein] = S-adenosyl-L-homocysteine + N-terminal-N,N-dimethyl-N-PPK-[protein]
show the reaction diagram
(2b)
-
-
-
S-adenosyl-L-methionine + N-terminal-PPK-[protein] = S-adenosyl-L-homocysteine + N-terminal-N-methyl-N-PPK-[protein]
show the reaction diagram
(2a)
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-
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