EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.1.1.227 | S-adenosyl-L-methionine + cytidine1409 in 16S rRNA |
- |
Geobacillus stearothermophilus |
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1409 in 16S rRNA |
- |
? |
2.1.1.227 | more |
the 2'-O-methyltransferase TlyA from Mycobacterium tuberculosis methylates both nucleotide C1409 of 16S rRNA and C1920 of 23S rRNA, EC 2.1.1.226 |
Mycobacterium tuberculosis |
? |
- |
? |
2.1.1.227 | more |
the recombinant enzyme poorly modifies the nucleotide C1409 in vitro in all Escherichia coli ribosomal substrates evaluated: 16S rRNA, 30S ribosomal subunits, and 70S ribosomes |
Mycobacterium tuberculosis |
? |
- |
? |
2.1.1.227 | more |
the bifunctional enzyme exhibits the activities of EC 2.1.1.226 and EC 2.1.1.227 |
Mycobacterium tuberculosis |
? |
- |
- |
2.1.1.227 | S-adenosyl-L-methionine + cytidine1409 in 16S rRNA |
- |
Mycobacterium tuberculosis |
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1409 in 16S rRNA |
- |
? |
2.1.1.227 | S-adenosyl-L-methionine + cytidine1409 in 16S rRNA |
the bifunctional enzyme modifies nucleotide C1409 in helix 44 of 16S rRNA and nucleotide C1920 in helix 69 of 23S rRNA |
Mycobacterium tuberculosis |
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1409 in 16S rRNA |
the exact position of the methyl group in the wild-type rRNAs is verified by MALDI quadrupole-TOF tandem MS analysis |
? |
2.1.1.227 | more |
the bifunctional enzyme exhibits the activities of EC 2.1.1.226 and EC 2.1.1.227 |
Mycobacterium tuberculosis H37Rv |
? |
- |
- |
2.1.1.227 | more |
the 2'-O-methyltransferase TlyA from Mycobacterium tuberculosis methylates both nucleotide C1409 of 16S rRNA and C1920 of 23S rRNA, EC 2.1.1.226 |
Mycobacterium tuberculosis H37Rv |
? |
- |
? |
2.1.1.227 | more |
the recombinant enzyme poorly modifies the nucleotide C1409 in vitro in all Escherichia coli ribosomal substrates evaluated: 16S rRNA, 30S ribosomal subunits, and 70S ribosomes |
Mycobacterium tuberculosis H37Rv |
? |
- |
? |
2.1.1.227 | S-adenosyl-L-methionine + cytidine1409 in 16S rRNA |
- |
Mycobacterium tuberculosis H37Rv |
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1409 in 16S rRNA |
- |
? |