EC Number   |
Substrates |
Organism |
Products  |
Reversibility |
|---|
    6.3.4.2 | more |
key enzyme for biosynthesis of cytosine ribonucleotides |
Homo sapiens |
? |
- |
? |
| 6.3.4.2 | more |
the enzyme catalyzes the rate-limiting step in synthesis of cytosine nucleotides from both de novo and uridine-salvage pathways |
Homo sapiens |
? |
- |
? |
| 6.3.4.2 | more |
rate-limiting enzyme in the synthesis of cytosine nucleotides from both de novo and uridine-salvage pathways. In human lymphoblastic leukemia cells the synthesis of CTP occurs predominantly via CTP synthetase, whereas in proliferating normal human T lymphocytes the salvage of cytidine is preferred |
Homo sapiens |
? |
- |
? |
| 6.3.4.2 | more |
repression of the pyrG gene encoding cytidine triphosphate synthetase is responsive to cytidine nucleotide levels and is independent of both uridine nucleotides and PyrR-dependent attenuation |
Bacillus subtilis |
? |
- |
? |
| 6.3.4.2 | more |
CTP limitation increases expression of CTP synthase in Lactococcus lactis. At normal CTP concentrations a terminator is preferentially formed in the pyrG leader, thereby reducing expression of CTP synthase. At low CTP concentrations the RNA polymerase pauses at a stretch of C residues inthe pyrG leader, thereby allowing an antiterminator to form and transcription to proceed |
Lactococcus lactis |
? |
- |
? |
| 6.3.4.2 | more |
in Lactococcus lactis the pyrG gene product is the only enzyme responsible for the amination of UTP to CTP |
Lactococcus lactis |
? |
- |
? |
| 6.3.4.2 | more |
the enzyme is one of the key enzymes in pyrimidine nucleotide anabolic pathways. The activity of this enzyme is elevated in various malignancies including acute lymphocytic leukemia |
Homo sapiens |
? |
- |
? |
| 6.3.4.2 | more |
CTP synthetase plays a pivotal role in the synthesis of CTP and dCTP |
Homo sapiens |
? |
- |
? |
| 6.3.4.2 | more |
CTP synthetase plays a pivotal role in the synthesis of CTP and dCTP |
Mus musculus |
? |
- |
? |
| 6.3.4.2 | more |
CTP synthetase plays a pivotal role in the synthesis of CTP and dCTP |
Saccharomyces cerevisiae |
? |
- |
? |
